Chest Wall Deformities in Youngsters – Epidemiological Information
Earlier research recommend that sulfation of proteoglycans performs an important position within the regular growth of cartilage and bone and will due to this fact be essential within the genesis of the illness.
The fundamental catalytic equipment accountable for the biosynthesis and breakage of sulfate esters within the proteoglycans consists of varied enzymes and transporters.
Mutations in Sphingosine Kinase 1 (SK1) and Sphingosine Kinase 2 (SK2) genes that encode the transmembrane transporters of sulfate or enzymes which are concerned in 3′-phosphoadenosine 5′-phosphosulfate (PAPS) synthesis have been recognized as the reason for a number of inherited illnesses that each one have skeletal system deformities.
Connections between chest wall deformities with syndromes (e.g. Marfan, Noonan), anomalies (e.g. Poland, Moebius) or associations (e.g. Cantrell Pentalogy, PHACE) are well-known. In distinction, there have to this point been hardly any genetic research of the remoted congenital chest wall deformities.
Epidemiological knowledge are inadequate and just a few teams take care of the inheritance and the incidence of this illness when it happens in isolation.
Chicken TGFR ELISA Kit |
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| ECKT0062 | Abclonal | 96Tests | EUR 625.2 |
Anserini TGFR ELISA Kit |
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| EAT0062 | Abclonal | 96Tests | EUR 625.2 |
Guinea Pig TGFR ELISA Kit |
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| EGT0062 | Abclonal | 96Tests | EUR 625.2 |
Recombinant Human ALK-1 Protein |
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| RP00978 | Abclonal | 5 μg | EUR 163.2 |
Recombinant Human ALK-1 Protein |
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| VAng-2860Lsx-10g | Creative Biolabs | 10 µg | EUR 736.8 |
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Description: Recombinant Human ALK-1 was expressed in Sf9 Insect Cells. (Uniprot ID: P37023) |
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Recombinant Human ALK-1 Protein |
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| VAng-2860Lsx-1mg | Creative Biolabs | 1 mg | EUR 16605.6 |
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Description: Recombinant Human ALK-1 was expressed in Sf9 Insect Cells. (Uniprot ID: P37023) |
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Goat anti Human IgG (Alk Phos) |
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| 43C-CB0963 | Fitzgerald | 1 mg | EUR 433.2 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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Goat anti Human IgG (Alk Phos) |
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| 43C-CB0978 | Fitzgerald | 1 mg | EUR 483.6 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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Goat anti Human IgM (Alk Phos) |
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| 43C-CB0999 | Fitzgerald | 1 mg | EUR 456 |
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Description: Goat anti Human IgM secondary antibody (Alk Phos) |
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Goat anti Human IgG (Alk Phos) |
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| 43R-1169 | Fitzgerald | 1 mg | EUR 223.2 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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Goat anti Human IgG (Alk Phos) |
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| 43R-1175 | Fitzgerald | 1 mg | EUR 268.8 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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Goat anti Human IgG (Alk Phos) |
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| 43R-1192 | Fitzgerald | 1 mg | EUR 315.6 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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Goat anti Human IgG (Alk Phos) |
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| 43R-1204 | Fitzgerald | 500 ug | EUR 355.2 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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Goat anti Human IgG (Alk Phos) |
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| 43R-IG012alk | Fitzgerald | 1 ml | EUR 658.8 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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Goat anti Human IgG (Alk Phos) |
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| 43R-IG165ALK | Fitzgerald | 1 mg | EUR 268.8 |
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Description: Goat anti Human IgG secondary antibody (Alk Phos) |
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Rabbit anti Human IgG (Alk Phos) |
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| 43C-CB0949 | Fitzgerald | 1 mg | EUR 526.8 |
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Description: Rabbit anti Human IgG secondary antibody (Alk Phos) |
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Rabbit anti Human IgG (Alk Phos) |
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| 43C-CB0956 | Fitzgerald | 1 mg | EUR 450 |
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Description: Rabbit anti Human IgG secondary antibody (Alk Phos) |
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Rabbit anti Human IgG (Alk Phos) |
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| 43C-CB0970 | Fitzgerald | 1 mg | EUR 450 |
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Description: Rabbit anti Human IgG secondary antibody (Alk Phos) |
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Rabbit anti Human IgM (Alk Phos) |
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| 43C-CB9106 | Fitzgerald | 1 mg | EUR 522 |
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Description: Rabbit anti Human IgM secondary antibody (Alk Phos) |
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Rabbit anti Human IgA (Alk Phos) |
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| 43C-CB9120 | Fitzgerald | 1 mg | EUR 475.2 |
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Description: Rabbit anti Human IgA secondary antibody (Alk Phos) |
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ALK-1 Polyclonal Antibody |
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| 41591-100ul | SAB | 100ul | EUR 302.4 |
ALK-1 Polyclonal Antibody |
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| 41591-50ul | SAB | 50ul | EUR 224.4 |
ALK-1 Polyclonal Antibody |
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| ABP52913-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1 |
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ALK-1 Polyclonal Antibody |
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| ABP52913-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1 |
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ALK-1 Polyclonal Antibody |
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| ABP52913-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1 |
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ALK-1 Polyclonal Antibody |
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| ABP57032-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250 |
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ALK-1 Polyclonal Antibody |
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| ABP57032-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250 |
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ALK-1 Polyclonal Antibody |
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| ABP57032-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250 |
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ALK-1 Polyclonal Antibody |
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| ES3912-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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ALK-1 Polyclonal Antibody |
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| ES3912-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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ALK-1 Polyclonal Antibody |
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| ES8031-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
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ALK-1 Polyclonal Antibody |
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| ES8031-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
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Anti-ALK-1 antibody |
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| STJ96547 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to ALK-1. |
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Anti-ALK-1 antibody |
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| STJ91563 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to ALK-1. |
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Nori® Human ALK-1 ELISA Kit |
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| GR111542 | Genorise Scientific | 96-well | EUR 461 |
Human ALK and LTK ligand 1 (ALKAL1) |
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| 1-CSB-EP757795HU | Cusabio |
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Description: Recombinant Human ALK and LTK ligand 1(ALKAL1) expressed in E.coli |
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ELISA kit for Human ALK-1/ACVRL1 |
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| EK5715 | SAB | 96 tests | EUR 663.6 |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Human ALK-1/ACVRL1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
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Goat anti Human IgG Fc (Alk Phos) |
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| 43-I24 | Fitzgerald | 100 ug | EUR 198 |
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Description: Goat anti Human IgG Fc secondary antibody (Alk Phos) |
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ALK-IN-1 |
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| HY-13464 | MedChemExpress | 100mg | EUR 472.8 |
Human ALK-1/ACVRL1 PicoKine ELISA Kit |
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| EK1518 | BosterBio | 96 wells | EUR 510 |
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Description: For quantitative detection of human ALK-1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
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ALK inhibitor 1 |
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| HY-15357 | MedChemExpress | 50mg | EUR 1712.4 |
Goat anti Human Kappa Chain (Alk Phos) |
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| 43C-CB9127 | Fitzgerald | 1 mg | EUR 500.4 |
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Description: Goat anti Human Kappa Chain secondary antibody (Alk Phos) |
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Goat anti Human kappa chain (Alk Phos) |
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| 43R-1257 | Fitzgerald | 500 ug | EUR 482.4 |
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Description: Goat anti Human kappa chain secondary antibody (Alk Phos) |
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Goat anti Human Lambda Chain (Alk Phos) |
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| 43C-CB9134 | Fitzgerald | 1 mg | EUR 500.4 |
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Description: Goat anti Human Lambda Chain secondary antibody (Alk Phos) |
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Goat anti Human IgG (H + L) (Alk Phos) |
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| 43C-CB0921 | Fitzgerald | 1 mg | EUR 205.2 |
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Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Goat anti Human IgG (H + L) (Alk Phos) |
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| 43C-CB0928 | Fitzgerald | 1 mg | EUR 417.6 |
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Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Goat anti Human IgG (H + L) (Alk Phos) |
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| 43C-CB0935 | Fitzgerald | 1 mg | EUR 543.6 |
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Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Goat anti Human IgG (H + L) (Alk Phos) |
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| 43R-1145 | Fitzgerald | 1 mg | EUR 268.8 |
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Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Goat anti Human IgG (H + L) (Alk Phos) |
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| 43R-1157 | Fitzgerald | 500 ug | EUR 268.8 |
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Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Goat anti Human IgG (H + L) (Alk Phos) |
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| 43R-1163 | Fitzgerald | 500 ug | EUR 315.6 |
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Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
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ALK-1 Polyclonal Conjugated Antibody |
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| C41591 | SAB | 100ul | EUR 476.4 |
Rabbit anti Human IgG (H + L) (Alk Phos) |
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| 43C-CB0914 | Fitzgerald | 1 mg | EUR 478.8 |
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Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Goat anti Human IgG + IgA + IgM (Alk Phos) |
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| 43R-1245 | Fitzgerald | 1 mg | EUR 205.2 |
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Description: Goat anti Human IgG + IgA + IgM secondary antibody (Alk Phos) |
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Goat anti Human IgG + IgA + IgM (Alk Phos) |
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| 43R-1251 | Fitzgerald | 500 ug | EUR 268.8 |
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Description: Goat anti Human IgG + IgA + IgM secondary antibody (Alk Phos) |
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Rabbit anti Human IgG (H + L) (Alk Phos) |
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| 43R-1269 | Fitzgerald | 1 mg | EUR 295.2 |
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Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Donkey anti Human IgG (H + L) (Alk Phos) |
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| 43R-ID001alk | Fitzgerald | 500 ul | EUR 390 |
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Description: Donkey anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Rabbit anti Human IgG (H + L) (Alk Phos) |
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| 43-I23 | Fitzgerald | 1 mg | EUR 435.6 |
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Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos) |
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Anti-ALK Antibody Clone ALK/1503, Unconjugated-20ug |
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| 238-MSM3-P0 | EnQuireBio | 20ug | EUR 279.6 |
Anti-ALK Antibody Clone ALK/1503, Unconjugated-100ug |
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| 238-MSM3-P1 | EnQuireBio | 100ug | EUR 513.6 |
Goat anti Human IgM (mu chain) (Alk Phos) |
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| 43R-1227 | Fitzgerald | 1 mg | EUR 274.8 |
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Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos) |
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Goat anti Human IgM (mu chain) (Alk Phos) |
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| 43R-1233 | Fitzgerald | 500 ug | EUR 456 |
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Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos) |
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Goat anti Human IgM (mu chain) (Alk Phos) |
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| 43R-1239 | Fitzgerald | 500 ug | EUR 456 |
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Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos) |
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Goat anti Human IgM (mu chain) (Alk Phos) |
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| 43-I34 | Fitzgerald | 1 mg | EUR 232.8 |
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Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos) |
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Recombinant Human ALK-1 Protein (aa 22-503) |
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| VAng-2854Lsx-100g | Creative Biolabs | 100 µg | EUR 8440.8 |
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Description: Recombinant Human ALK-1 was expressed in cell free expression systems. (Uniprot ID: P37023) |
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Recombinant Human ALK-1 Protein (aa 22-503) |
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| VAng-2854Lsx-50g | Creative Biolabs | 50 µg | EUR 5454 |
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Description: Recombinant Human ALK-1 was expressed in cell free expression systems. (Uniprot ID: P37023) |
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Recombinant Human ALK-1 Protein (aa 22-118) |
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| VAng-2856Lsx-1mg | Creative Biolabs | 1 mg | EUR 3393.6 |
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Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
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Recombinant Human ALK-1 Protein (aa 22-118) |
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| VAng-2856Lsx-200g | Creative Biolabs | 200 µg | EUR 2205.6 |
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Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
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Recombinant Human ALK-1 Protein (aa 22-118) |
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| VAng-2856Lsx-500g | Creative Biolabs | 500 µg | EUR 2419.2 |
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Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
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ALK-1 Recombinant Protein |
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| 92-565 | ProSci | 0.05 mg | EUR 374.1 |
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Description: Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF- beta superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair. |
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ALK sgRNA CRISPR Lentivector (Human) (Target 1) |
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| K0074502 | ABM | 1.0 ug DNA | EUR 184.8 |
Goat anti Human IgA (alpha chain) (Alk Phos) |
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| 43R-1119 | Fitzgerald | 500 ug | EUR 355.2 |
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Description: Goat anti Human IgA (alpha chain) secondary antibody (Alk Phos) |
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Goat anti Human IgG (gamma chain) (Alk Phos) |
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| 43R-1659 | Fitzgerald | 1 mg | EUR 301.2 |
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Description: Goat anti Human IgG (gamma chain) secondary antibody (Alkaline Phosphatase) |
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Goat anti Human IgA (alpha chain) (Alk Phos) |
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| 43-I10 | Fitzgerald | 1 mg | EUR 355.2 |
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Description: Goat anti Human IgA (alpha chain) secondary antibody (Alk Phos) |
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Goat anti Human IgE (epsilon chain) (Alk Phos) |
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| 43R-1129 | Fitzgerald | 1 mg | EUR 456 |
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Description: Goat anti Human IgE (epsilon chain) secondary antibody (Alk Phos) |
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Goat anti Human IgE (epsilon chain) (Alk Phos) |
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| 43R-1134 | Fitzgerald | 500 ug | EUR 456 |
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Description: Goat anti Human IgE (epsilon chain) secondary antibody (Alk Phos) |
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Goat Anti Human Ige Polyclonal Antibody,Alk. Phos. |
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| CPBT-65486GH | Creative Diagnostics | 0.5 mg | EUR 696 |
anti- ALK,CD246 antibody |
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| FNab00309 | FN Test | 100µg | EUR 606.3 |
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Description: Antibody raised against ALK,CD246 |
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anti- ALK,CD246 antibody |
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| FNab00310 | FN Test | 100µg | EUR 606.3 |
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Description: Antibody raised against ALK,CD246 |
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Recombinant Human ALK-1 Protein (aa 22-118) [Fc] |
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| VAng-2859Lsx-50g | Creative Biolabs | 50 µg | EUR 621.6 |
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Description: Recombinant Human ALK-1 was expressed in HEK 293 cells. (Uniprot ID: P37023) |
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Recombinant Human ALK-1 Protein (aa 238-479) [His] |
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| VAng-2861Lsx-1mg | Creative Biolabs | 1 mg | EUR 3952.8 |
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Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
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Recombinant Human ALK-1 Protein (aa 238-479) [His] |
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| VAng-2861Lsx-200g | Creative Biolabs | 200 µg | EUR 1429.2 |
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Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
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Recombinant Human ALK-1 Protein (aa 238-479) [His] |
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| VAng-2861Lsx-500g | Creative Biolabs | 500 µg | EUR 2700 |
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Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
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Recombinant Human Activin Receptor-Like Kinase 1/ALK-1(C-Fc) |
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| C422-10ug | Novoprotein | 10ug | EUR 96 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Human Activin Receptor-Like Kinase 1/ALK-1(C-Fc) |
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| C422-1mg | Novoprotein | 1mg | EUR 1216.8 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Human Activin Receptor-Like Kinase 1/ALK-1(C-Fc) |
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| C422-500ug | Novoprotein | 500ug | EUR 790.8 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Human Activin Receptor-Like Kinase 1/ALK-1(C-Fc) |
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| C422-50ug | Novoprotein | 50ug | EUR 169.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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ALK 1 Recombinant Protein |
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| 96-022 | ProSci | 0.1 mg | EUR 619.8 |
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Description: Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ALK1 gene. ALK1 is a receptor in the TGF beta signaling pathway. ALK1 protein is a receptor in the TGF beta signaling pathway. It plays an important role in vascular development, remodeling, and pathologic angiogenesis, play a role in stabilizing angiogenic vessels and contribute to resistance to anti-VEGF therapies, ALK1 blockade may represent an effective therapeutic opportunity complementary to the current antiangiogenic modalities in the clinic. Recently, researcher found that, ALK1-Fc inhibited BMP9-mediated Id-1 expression in human umbilical vein endothelial cells and inhibited cord formation by these cells on a Matrigel substrate, in a chick chorioallantoic membrane assay, ALK1-Fc reduced vascular endothelial growth factor-, fibroblast growth factor-, and BMP10-mediated vessel formation, and ALK1-Fc treatment reduced tumor burden in mice receiving orthotopic grafts of MCF7 mammary adenocarcinoma cells. |
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Goat Anti Human Igg (Fc) Polyclonal Antibody,Alk. Phos. |
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| CPBT-65492GH | Creative Diagnostics | 1 mg | EUR 920.4 |
Human ALK Tyrosine Kinase Receptor (ALK) ELISA Kit |
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| abx250524-96tests | Abbexa | 96 tests | EUR 1064.4 |
Research of AIC100 in Relapsed/Refractory Thyroid Most cancers
The main goal of this research is to evaluate the security and decide the beneficial dose of AIC100 for part II research in sufferers with relapsed/refractory poorly differentiated thyroid most cancers and in sufferers with anaplastic thyroid most cancers which are BRAF wild-type, or BRAF mutant anaplastic thyroid most cancers after failure of BRAF-mutant particular remedy.
Upon enrollment, sufferers will endure leukapheresis for assortment of autologous lymphocytes. The autologous T cells shall be transfected and expanded in-vitro to generate the AIC100 product.
After lymphodepleting remedy, AIC100 shall be infused.
The research drug, AIC100, consists of autologous CAR T cells containing the I area of lymphocyte function-associated antigen-1 (LFA-1) and concentrating on its over-expressed physiological ligand, intercellular adhesion molecule-1 (ICAM-1) on thyroid most cancers.
AIC100 cells additionally specific the transmembrane area of CD8 alpha and intracellular domains of the co-stimulatory receptors CD28 and 41BB, and the cytoplasmic signaling area of the T cell receptor related CD3.
As well as, AIC100 cells specific the somatostatin receptor subtype 2 (SSTR2), which ought to allow CAR T cell imaging within the affected person.
The therapy with AIC100 is a single dose infusion. Nevertheless, extra infusions could also be administered if the next situations are met:
(1) affected person reveals secure illness or partial response per Response Analysis Standards in Strong Tumors (RECIST) v1.1 after 30 days.
(2) The investigator has deemed it’s in the very best curiosity of the affected person.
(3) Affected person didn’t expertise a dose limiting toxicity (DLT).
(4) There are cell doses accessible from the already manufactured cell product. The cell dose for subsequent infusions shall be just like that of the preliminary dose.
In particular person circumstances and solely with the specific approval of the Information and Security Monitoring Board (DSMB) and Meals and Drug Administration (FDA), a better dose could possibly be administered.
This might sometimes be justified by efficacy and toxicity knowledge generated in different individuals. Previous to extra infusions, lymphodepleting chemotherapy shall be repeated.
Enrollment shall be staggered so that every affected person shall be adopted for no less than 30 days previous to enrollment of the subsequent affected person for the preliminary Dose 1 cohort.
It is a dose escalation research utilizing cohorts of three sufferers. Sufferers will obtain a flat dose of 1 x 10e7, 1 x 10e8 or 5 x 10e8 viable CAR T cells with a dose -1 Cohort of 1 x 10e6.
Trial of Alpha One Antitrypsin Inhalation in Treating Affected person With Extreme Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2
It’s clear now that SARS-CoV-2 may use angiotensin-converting enzyme 2 (ACE2), the identical receptor as SARS-CoV Transmembrane protease serine sort 2 (TMPRSS2), a protease belonging to the kind II transmembrane serine protease household, cleaves the coronavirus spike protein Serine proteases are inhibited by a various group of inhibitors, The perfect-studied serpins are antithrombin and alpha 1-antitrypsin
Anti-IL-17 antibody |
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| PAab04224 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-IL-17 alpha antibody |
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| STJ93683 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to IL-17Ralpha. |
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Recombinant Human IL-17 |
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| SJB09-03 | Amyotop | 25µg/vial | EUR 307.2 |
Human Interleukin 17 (IL-17) CLIA Kit |
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| abx195860-96tests | Abbexa | 96 tests | EUR 990 |
Human Interleukin 17,IL-17 ELISA Kit |
|||
| 201-12-0143 | SunredBio | 96 tests | EUR 528 |
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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Human Interleukin 17,IL-17 ELISA Kit |
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| CN-03335H1 | ChemNorm | 96T | EUR 520.8 |
Human Interleukin 17,IL-17 ELISA Kit |
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| CN-03335H2 | ChemNorm | 48T | EUR 340.8 |
Human Interleukin 17(IL-17)ELISA Kit |
|||
| GA-E0081HM-48T | GenAsia Biotech | 48T | EUR 346.8 |
Human Interleukin 17(IL-17)ELISA Kit |
|||
| GA-E0081HM-96T | GenAsia Biotech | 96T | EUR 559.2 |
Human Interleukin 17(IL-17)ELISA Kit |
|||
| QY-E04323 | Qayee Biotechnology | 96T | EUR 433.2 |
Human Interleukin 17,IL-17 ELISA Kit |
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| YLA1538HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
Human Interleukin 17,IL-17 ELISA Kit |
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| YLA1538HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
IL-17 Interleukin-17 Human Recombinant Protein |
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| PROTQ16552-1 | BosterBio | Regular: 25ug | EUR 380.4 |
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Description: Interleukin-17A Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 264 amino acids (2 chains of 132 aa) and having a molecular mass of 31kDa. ;The IL-17 is purified by proprietary chromatographic techniques. |
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Recombinant Human IL-17 (IL-17A) Protein |
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| PROTQ16552-4 | BosterBio | 25ug | EUR 380.4 |
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Description: The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.3 kDa disulfide-linked homodimer of two 137 amino acid polypeptide chains. |
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human IL-17, His tag |
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| E410A10-100 | EnoGene | 100μg | EUR 1152 |
IL-17 (Human) ELISA Kit |
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| E4628-100 | Biovision | each | EUR 874.8 |
Human IL-17 ELISA kit |
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| LF-EK50201 | Abfrontier | 1×96T | EUR 777.6 |
IL-17 ELISA KIT|Human |
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| EF006939 | Lifescience Market | 96 Tests | EUR 826.8 |
Interleukin 17 (IL-17) Antibody |
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| abx234224-100ug | Abbexa | 100 ug | EUR 610.8 |
Interleukin 17 (IL-17) Antibody |
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| abx234225-100ug | Abbexa | 100 ug | EUR 577.2 |
IL-17 Antibody |
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| 5176-100 | Biovision | each | EUR 405.6 |
IL-17 Antibody |
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| 4877-002mg | ProSci | 0.02 mg | EUR 206.18 |
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Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases. |
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IL-17 Antibody |
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| 4877-01mg | ProSci | 0.1 mg | EUR 523.7 |
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Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases. |
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IL-17 Antibody |
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| 4887-002mg | ProSci | 0.02 mg | EUR 206.18 |
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Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases. |
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IL-17 Antibody |
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| 4887-01mg | ProSci | 0.1 mg | EUR 523.7 |
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Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases. |
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IL-17 Antibody |
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| 24784-100ul | SAB | 100ul | EUR 468 |
IL-17 Antibody |
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| 24789-100ul | SAB | 100ul | EUR 468 |
IL-17 Antibody |
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| F42568-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
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Description: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. |
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IL-17 Antibody |
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| R35097-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
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Description: Additional name(s) for this target protein: Interleukin 17A; IL17A |
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IL-17 Antibody |
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| R36188-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
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Description: Additional name(s) for this target protein: Interleukin 17A antibody, IL17A, CTLA8 |
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CLIA kit for Human IL-17 (Interleukin 17) |
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| E-CL-H0104 | Elabscience Biotech | 1 plate of 96 wells | EUR 700.8 |
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Description: A sandwich CLIA kit for quantitative measurement of Human IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant |
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ELISA kit for Human IL-17 (Interleukin 17) |
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| E-EL-H0105 | Elabscience Biotech | 1 plate of 96 wells | EUR 452.4 |
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Description: A sandwich ELISA kit for quantitative measurement of Human IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant |
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Human Interleukin 17 (IL-17) Detection Assay Kit |
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| 6808 | Chondrex | 1 kit | EUR 580.26 |
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Description: Human Interleukin 17 (IL-17) Detection Assay Kit |
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IL-17 Interleukin-17 Human Recombinant Protein, HEK |
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| PROTQ16552 | BosterBio | Regular: 10ug | EUR 380.4 |
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Description: IL-17 Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight range of 30-35kDa due to glycosylation.;The IL-17 is purified by proprietary chromatographic techniques. |
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IL-17 |
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| E5-00007 | EnoGene | 1mg | EUR 1152 |
IL-17 |
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| MO15110 | Neuromics | 500 ug | EUR 1092 |
IL-17 |
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| EF014060 | Lifescience Market | 96 Tests | EUR 826.8 |
IL-17 |
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| PR27113 | Neuromics | 5 ug | EUR 229.2 |
IL-17/IL-17A |
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| E21-021 | EnoGene | 10ug | EUR 411.6 |
ELISA kit for Human IL-17 |
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| KET6022-48T | Abbkine | 48T | EUR 242.4 |
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Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Human IL-17 |
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| KET6022-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 1292.4 |
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Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Human IL-17 |
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| KET6022-96T | Abbkine | 96T | EUR 346.8 |
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Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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Human IL-17 ELISA kit (4X96T) |
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| LF-EK50202 | Abfrontier | 4×96T | EUR 2641.2 |
CymaxTM Human IL-17 ELISA Kit |
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| LF-EK0295 | Abfrontier | 1×96T | EUR 477.6 |
Human IL-17 PicoKine ELISA Kit |
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| EK0430 | BosterBio | 96 wells | EUR 510 |
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Description: For quantitative detection of human IL-17 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
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IL-17 Interleukin-17 Human Recombinant Protein, His Tag |
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| PROTQ16552-2 | BosterBio | Regular: 10ug | EUR 380.4 |
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Description: Interleukin-17A Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 132 amino acids fragment (24-155) having a molecular weight of 19.62kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. ;The IL-17A His is purified by proprietary chromatographic techniques. |
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Human Interleukin 17A (IL-17A/IL-17) ELISA Kit |
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| CSB-E12819h-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
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Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 17A (IL-17A/IL-17) in samples from serum, urine, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Human Interleukin 17A (IL-17A/IL-17) ELISA Kit |
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| 1-CSB-E12819h | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 17A (IL-17A/IL-17) in samples from serum, urine, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Polyclonal IL-17 Antibody |
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| APR06508G | Leading Biology | 0.1 mg | EUR 790.8 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-17 . This antibody is tested and proven to work in the following applications: |
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Polyclonal IL-17 Antibody |
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| APR06512G | Leading Biology | 0.1 mg | EUR 790.8 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-17 . This antibody is tested and proven to work in the following applications: |
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Bovine Interleukin 17(IL-17) |
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| QY-E60069 | Qayee Biotechnology | 96T | EUR 511.2 |
IL-17 Peptide |
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| 4877P | ProSci | 0.05 mg | EUR 197.7 |
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Description: (NT) IL-17 peptide |
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IL-17 Peptide |
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| 4887P | ProSci | 0.05 mg | EUR 197.7 |
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Description: (IN) IL-17 peptide |
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Genorise® Anti-canine IL-17 Polyclonal Antibody |
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| GR105162 | Genorise Scientific | 100 ug | EUR 438 |
Human Interleukin-17,IL-17A ELISA Kit |
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| ELA-E1700h | Lifescience Market | 96 Tests | EUR 988.8 |
IL-17 receptor D antibody |
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| 22228-100ul | SAB | 100ul | EUR 468 |
Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc) |
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| CI53-10ug | Novoprotein | 10ug | EUR 120 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc) |
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| CI53-1mg | Novoprotein | 1mg | EUR 1094.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc) |
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| CI53-500ug | Novoprotein | 500ug | EUR 850.8 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc) |
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| CI53-50ug | Novoprotein | 50ug | EUR 242.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Human IL-17A(Interleukin 17 A) ELISA Kit |
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| EH3267 | FN Test | 96T | EUR 571.5 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml |
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Genorise® Biotinylated Anti-equine IL-17 Polyclonal Antibody |
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| GR109027 | Genorise Scientific | 50 mg | EUR 398 |
Genorise® Biotinylated Anti-canine IL-17 Polyclonal Antibody |
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| GR109179 | Genorise Scientific | 50 mg | EUR 398 |
Human Interleukin-17 A (IL-17A) ELISA Kit |
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| LF-EK60049 | Abfrontier | 1×96T | EUR 948 |
Anti Human 17? HSD 8 Polyclonal Antibody |
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| KR099 | Sceti | each | EUR 778.8 |
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Description: The Anti Human 17? HSD 8 Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur. |
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IL-17 Recombinant Protein |
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| 91-616 | ProSci | 0.05 mg | EUR 588.3 |
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Description: Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. |
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IL-17 Recombinant Protein |
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| 91-015 | ProSci | 0.05 mg | EUR 437.1 |
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Description: Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. |
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rHu IL-17-A |
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| AK8249-0005 | Akron Biotech | 5µg | Ask for price |
rHu IL-17-A |
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| AK8249-0025 | Akron Biotech | 25µg | Ask for price |
rHu IL-17-A |
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| AK8249-0100 | Akron Biotech | 100µg | Ask for price |
rHu IL-17-A |
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| AK8249-1000 | Akron Biotech | 1mg | Ask for price |
rHu IL-17-E |
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| AK8299-0005 | Akron Biotech | 5µg | Ask for price |
rHu IL-17-E |
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| AK8299-0025 | Akron Biotech | 25µg | Ask for price |
rHu IL-17-E |
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| AK8299-0100 | Akron Biotech | 100µg | Ask for price |
rHu IL-17-E |
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| AK8299-1000 | Akron Biotech | 1mg | Ask for price |
rHu IL-17-F |
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| AK8312-0005 | Akron Biotech | 5µg | Ask for price |
rHu IL-17-F |
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| AK8312-0025 | Akron Biotech | 25µg | Ask for price |
rHu IL-17-F |
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| AK8312-0100 | Akron Biotech | 100µg | Ask for price |
rHu IL-17-F |
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| AK8312-1000 | Akron Biotech | 1mg | Ask for price |
Rabbit Interleukin 17,IL-17 ELISA Kit |
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| CN-00640R1 | ChemNorm | 96T | EUR 542.4 |
Rabbit Interleukin 17,IL-17 ELISA Kit |
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| CN-00640R2 | ChemNorm | 48T | EUR 362.4 |
Chicken Interleukin 17,IL-17 ELISA Kit |
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| CN-00838C1 | ChemNorm | 96T | EUR 542.4 |
Chicken Interleukin 17,IL-17 ELISA Kit |
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| CN-00838C2 | ChemNorm | 48T | EUR 362.4 |
PoFAine interleukin 17,IL-17 ELISA Kit |
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| CN-01210P2 | ChemNorm | 48T | EUR 391.2 |
PoFAine interleukin 17,IL-17 ELISA Kit |
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| CN-01211P1 | ChemNorm | 96T | EUR 538.8 |
PoFAine interleukin 17,IL-17 ELISA Kit |
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| CN-01211P2 | ChemNorm | 48T | EUR 358.8 |
Rat Interleukin 17,IL-17 ELISA KIT |
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| CN-01495R1 | ChemNorm | 96T | EUR 538.8 |
Rat Interleukin 17,IL-17 ELISA KIT |
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| CN-01495R2 | ChemNorm | 48T | EUR 358.8 |
Mouse Interleukin 17,IL-17 ELISA Kit |
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| CN-02453M1 | ChemNorm | 96T | EUR 536.4 |
Mouse Interleukin 17,IL-17 ELISA Kit |
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| CN-02453M2 | ChemNorm | 48T | EUR 355.2 |
Chicken Interleukin 17, IL-17 ELISA Kit |
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| CSB-E04607Ch-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
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Description: Quantitativecompetitive ELISA kit for measuring Chicken Interleukin 17, IL-17 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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