Understanding the discrimination and quantification of monoclonal antibodies preparations using Raman spectroscopy

The usage of Raman spectroscopy for analytical high quality management of anticancer drug preparations in scientific pharmaceutical allotting models is growing in reputation, notably supported by commercially obtainable, objective designed devices. Though not legislatively obligatory, analytical strategies are incessantly used post-preparation to confirm the accuracy of a preparation when it comes to id and amount of the drug in answer. Nonetheless, whereas the fast, price efficient and label free evaluation achieved with Raman spectroscopy is interesting, it is very important perceive the molecular origin of the spectral contributions collected from the answer of actives and excipients, to guage the energy and limitation for the method, which can be utilized to establish and quantify both the prescribed business formulation, and/or the energetic drug itself, in personalised options.

Within the present research, 4 business formulations, Erbitux®, Truxima®, Ontruzant® and Avastin® of monoclonal antibodies (mAbs), corresponding respectively to cetuximab, rituximab, trastuzumab and bevacizumab have been used to focus on the important thing function of excipients in discrimination and quantification of the formulations. It’s demonstrated that protein based mostly anticancer medicine akin to mAbs have a comparatively weak Raman response, whereas excipients akin to glycine, trehalose or histidine contribute considerably to the spectra. Multivariate evaluation (partial least sq. regression and partial least sq. discriminant evaluation) additional demonstrates that the signatures of the mAbs themselves usually are not outstanding in mathematical fashions and that these of the excipients are solely liable for the differentiation of formulation and correct willpower of concentrations.

Whereas Raman spectroscopy can efficiently validate the conformity of mAbs intravenous infusion options, the idea for the evaluation ought to be thought of, and particular warning ought to be given to excipient compositions in business formulations to make sure reliability and reproducibility of the evaluation.

 

Preclinical and Scientific Improvement of Therapeutic Antibodies Concentrating on Features of CD47 within the Tumor Microenvironment

CD47 is a ubiquitously expressed cell floor glycoprotein that capabilities as a signaling receptor for thrombospondin-1 and because the counter-receptor for sign regulatory protein-α (SIRPα). Participating SIRPα on macrophages inhibits phagocytosis, and CD47 thereby serves as a physiological marker of self. Nonetheless, elevated CD47 expression on some most cancers cells additionally protects tumors from innate immune surveillance and limits adaptive antitumor immunity by way of inhibitory SIRPα signaling in antigen presenting cells. CD47 additionally mediates inhibitory thrombospondin-1 signaling in vascular cells, T cells, and NK cells, and blocking inhibitory CD47 signaling on cytotoxic T cells instantly will increase tumor cell killing.
Due to this fact, CD47 capabilities as an innate and adaptive immune checkpoint. These findings have led to the event of antibodies and different therapeutic approaches to dam CD47 capabilities within the tumor microenvironment. Preclinical research in mice demonstrated that blocking CD47 can restrict the expansion of hematologic malignancies and strong tumors and improve the efficacy of standard chemotherapy, radiation remedy, and a few focused most cancers therapies. Humanized CD47 antibodies are displaying promise in early scientific trials, however unwanted effects associated to enhanced phagocytic clearance of circulating blood cells stay a priority. Approaches to bypass these embody antibody preloading methods, growth of antibodies that acknowledge tumor-specific epitopes of CD47, SIRPα antibodies, and bivalent antibodies that limit CD47 blockade to particular tumor cells.
Preclinical and scientific growth of antibodies and associated biologics that inhibit CD47/SIRPα signaling are reviewed, together with methods to mix these brokers with numerous standard and focused therapeutics to enhance affected person end result for numerous cancers.

Most cancers in Systemic Sclerosis: Evaluation of antibodies in opposition to elements of the Th/To Complicated

Goal: The intention of this research is to explain 4 of the commonest autoantibodies in opposition to elements of the Th/To advanced: hPOP1, RPP25, RPP30, and RPP40. We report their prevalence and scientific traits in a systemic sclerosis (SSc) inhabitants, and decide whether or not these specificities affiliate with most cancers.
Strategies: A case management research was carried out using knowledge from the Johns Hopkins Scleroderma Heart Cohort. A complete of 804 grownup sufferers with SSc had been included; 401 SSc sufferers with no historical past of most cancers after a minimum of 5 years of illness had been in comparison with 403 SSc sufferers who ever had a historical past of most cancers. Antibodies in opposition to hPOP1, RPP25, RPP30, and RPP40 had been assayed by immunoprecipitation of 35 S-methionine-labeled proteins generated by in vitro transcription/translation. Demographic and scientific traits had been in contrast between teams.
Outcomes: 67/804 (8.3%) of sufferers had antibodies in opposition to any element of the Th/To advanced. Sufferers with antibodies to any element had been considerably extra more likely to have restricted cutaneous illness, much less more likely to have tendon friction rubs, and extra more likely to have findings in line with interstitial lung illness or pulmonary hypertension. Sufferers with antibodies in opposition to hPOP1, RPP25, RPP30, and/or RPP40 had been considerably much less more likely to develop most cancers inside 2 years of SSc-onset (0% vs 11%, p=0.016).

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit

RDR-MDC-Mu-48Tests 48 Tests
EUR 388

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit

RDR-MDC-Mu-96Tests 96 Tests
EUR 533

Human Macrophage Derived Chemokine (MDC) ELISA Kit

RD-MDC-Hu-48Tests 48 Tests
EUR 366

Human Macrophage Derived Chemokine (MDC) ELISA Kit

RD-MDC-Hu-96Tests 96 Tests
EUR 502

Rat Macrophage Derived Chemokine (MDC) ELISA Kit

RD-MDC-Ra-48Tests 48 Tests
EUR 511

Rat Macrophage Derived Chemokine (MDC) ELISA Kit

RD-MDC-Ra-96Tests 96 Tests
EUR 709

Human Macrophage Derived Chemokine (MDC) ELISA Kit

DLR-MDC-Hu-48T 48T
EUR 380
Description: A sandwich quantitative ELISA assay kit for detection of Human Macrophage Derived Chemokine (MDC) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Macrophage Derived Chemokine (MDC) ELISA Kit

DLR-MDC-Hu-96T 96T
EUR 485
Description: A sandwich quantitative ELISA assay kit for detection of Human Macrophage Derived Chemokine (MDC) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Macrophage Derived Chemokine (MDC) ELISA Kit

DLR-MDC-Ra-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Rat Macrophage Derived Chemokine (MDC) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Macrophage Derived Chemokine (MDC) ELISA Kit

DLR-MDC-Ra-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Rat Macrophage Derived Chemokine (MDC) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Macrophage Derived Chemokine (MDC) ELISA Kit

RDR-MDC-Hu-48Tests 48 Tests
EUR 382

Human Macrophage Derived Chemokine (MDC) ELISA Kit

RDR-MDC-Hu-96Tests 96 Tests
EUR 524

Rat Macrophage Derived Chemokine (MDC) ELISA Kit

RDR-MDC-Ra-48Tests 48 Tests
EUR 534

Rat Macrophage Derived Chemokine (MDC) ELISA Kit

RDR-MDC-Ra-96Tests 96 Tests
EUR 742

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

MDC/CCL22, Mouse

HY-P7248 10ug
EUR 268

MDC protein (Mouse)

30R-AM058 20 ug
EUR 273
Description: Purified recombinant Mouse MDC protein

MDC/ Rat MDC ELISA Kit

ELA-E0091r 96 Tests
EUR 886

MDC, CCL22, murine (mouse)

RC335-33 5ug
EUR 104.38

Mouse MDC ELISA Kit

EMM0016 96Tests
EUR 521

Mouse MDC ELISA Kit

EMM0217 96Tests
EUR 521

Mouse MDC ELISA Kit

RK00184 96 Tests
EUR 521

Mouse MDC ELISA kit

LF-EK50241 1×96T
EUR 648

Mouse MDC ELISA Kit

55R-1643 1 kit
EUR 590
Description: ELISA kit for detection of MDC in the research laboratory

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

MDC antibody

10R-M168A 500 ug
EUR 273
Description: Mouse monoclonal MDC antibody

MDC antibody

20R-1805 100 ug
EUR 673
Description: Rabbit polyclonal MDC antibody

MDC antibody

70R-12355 100 ug
EUR 447
Description: Rabbit polyclonal MDC antibody

MDC antibody

70R-MR020 50 ug
EUR 273
Description: Affinity purified Rabbit polyclonal MDC antibody

MDC antibody

70R-MR031 50 ug
EUR 273
Description: Affinity purified Rabbit polyclonal MDC antibody

MDC Antibody

5531-100
EUR 338

Rabbit Anti Human Mdc Polyclonal Antibody

CPBT-65206RH 0.1 mg
EUR 881

MDC ELISA Kit (Mouse) (OKBB00214)

OKBB00214 96 Tests
EUR 518
Description: Description of target: Macrophage-derived chemokine (MDC), also called Chemokine, cc motif, ligand 22 (CCL22) or Small inducible cytokine subfamily A, member 22 (SCY22). MDC is a recently identified member of the CC chemokine family. It is not closely related to other chemokines, sharing most similarity with thymus- and activation-regulated chemokine (TARC), which contains 37% identical amino acids. In addition, MDC gene is mapped to chromosome 16q13, the same position reported for the TARC gene. MDC has the four-cysteine motif and other highly conserved residues characteristic of CC chemokines, but it shares <35% identity with any of the known chemokines. Recombinant MDC was expressed in Chinese hamster ovary cells and purified by heparin-Sepharose chromatography. MDC is highly expressed in macrophages and in monocyte-derived dendritic cells, but not in monocytes, natural killer cells, or several cell lines of epithelial, endothelial, or fibroblast origin. High expression was also detected in normal thymus and less expression in lung and spleen. MDC is thus a unique member of the CC chemokine family that may play a fundamental role in the function of dendritic cells, natural killer cells, and monocytes.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 1 pg/mL

Mouse MDC ELISA kit (4X96T)

LF-EK50242 4×96T
EUR 2201

Rabbit Anti Human Mdc Polyclonal Antibody,Biotin

CPBT-65205RH 50 µg
EUR 881

Anti-EGFR (clone Bat0206)-SMCC-MDC ADC

ADC-W-127 1mg Ask for price
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody (clone Bat0206) conjugated via a SMCC linker to MDC

Anti-FAT1 (clone Bat0606)-SMCC-MDC ADC

ADC-W-128 1mg Ask for price
Description: This ADC product is comprised of an anti-fat R2 monoclonal antibody (clone Bat0206) conjugated via a SMCC linker to MDC

Anti-MS4A1 (clone Batl206)-SMCC-MDC ADC

ADC-W-129 1mg Ask for price
Description: This ADC product is comprised of an anti-MS4A1 monoclonal antibody (clone Bat0206) conjugated via a SMCC linker to MDC

MDC, CCL22, rat

RC355-33 5ug
EUR 104.38

MDC/CCL22, Rat

HY-P7249 50ug
EUR 533

MDC Recombinant Protein

40-350-0005mg 0.005 mg
EUR 259.25
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

MDC Recombinant Protein

40-350-002mg 0.02 mg
EUR 364.25
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

MDC Recombinant Protein

40-387-0005mg 0.005 mg
EUR 259.25
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.0 kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

MDC Recombinant Protein

40-387-002mg 0.02 mg
EUR 364.25
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.0 kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

MDC Recombinant Protein

40-388-0005mg 0.005 mg
EUR 259.25
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.1 kDa protein containing 69 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

MDC Recombinant Protein

40-388-002mg 0.02 mg
EUR 364.25
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.1 kDa protein containing 69 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

MDC, human recombinant

4617-100
EUR 697

MDC, human recombinant

4617-1000
EUR 3258

MDC, human recombinant

4617-20
EUR 251

Mouse Macrophage Derived Chemokine (MDC) Protein

20-abx067887
  • EUR 690.00
  • EUR 286.00
  • EUR 2124.00
  • EUR 815.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Anti-EGFR (clone Bat0206)-S-3AA-MDC ADC

ADC-W-126 1mg Ask for price
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody (clone Bat0206) conjugated via a S-3AA linker to MDC

Sheep MDC ELISA Kit

ESM0217 96Tests
EUR 521

Anserini MDC ELISA Kit

EAM0016 96Tests
EUR 521

Rat MDC ELISA Kit

ERM0016 96Tests
EUR 521

Rat MDC ELISA Kit

ERM0217 96Tests
EUR 521

Rabbit MDC ELISA Kit

ERTM0016 96Tests
EUR 521

Rabbit MDC ELISA Kit

ERTM0217 96Tests
EUR 521

Monkey MDC ELISA Kit

EMKM0217 96Tests
EUR 521

Porcine MDC ELISA Kit

EPM0016 96Tests
EUR 521

Porcine MDC ELISA Kit

EPM0217 96Tests
EUR 521

Human MDC ELISA Kit

EHM0016 96Tests
EUR 521

Human MDC ELISA Kit

EHM0217 96Tests
EUR 521

Chicken MDC ELISA Kit

ECKM0217 96Tests
EUR 521

Canine MDC ELISA Kit

ECM0016 96Tests
EUR 521

Canine MDC ELISA Kit

ECM0217 96Tests
EUR 521

Bovine MDC ELISA Kit

EBM0016 96Tests
EUR 521

Bovine MDC ELISA Kit

EBM0217 96Tests
EUR 521

Goat MDC ELISA Kit

EGTM0016 96Tests
EUR 521

Goat MDC ELISA Kit

EGTM0217 96Tests
EUR 521

MDC ELISA KIT|Human

EF000180 96 Tests
EUR 689

Human MDC ELISA kit

LF-EK50237 1×96T
EUR 648

Human MDC ELISA Kit

55R-1642 1 kit
EUR 550
Description: ELISA kit for detection of MDC in the research laboratory

Human MDC ELISA kit

55R-2065 96 tests
EUR 712
Description: ELISA Kit for detection of MDC in the research laboratory

MDC/CCL22, murine recombinant

7169-10
EUR 207

MDC/CCL22, murine recombinant

7169-50
EUR 675

Mouse Macrophage Derived Chemokine (MDC)CLIA Kit

SCA091Mu-10x96wellstestplate 10x96-wells test plate
EUR 5804.88
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Macrophage Derived Chemokine (MDC)CLIA Kit

SCA091Mu-1x48wellstestplate 1x48-wells test plate
EUR 565.7
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Macrophage Derived Chemokine (MDC)CLIA Kit

SCA091Mu-1x96wellstestplate 1x96-wells test plate
EUR 765.28
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Macrophage Derived Chemokine (MDC)CLIA Kit

SCA091Mu-5x96wellstestplate 5x96-wells test plate
EUR 3143.76
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit

4-SCA091Mu
  • EUR 5855.00
  • EUR 3144.00
  • EUR 766.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit

SEA091Mu-10x96wellstestplate 10x96-wells test plate
EUR 3409.41
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit

SEA091Mu-1x48wellstestplate 1x48-wells test plate
EUR 368.42
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit

SEA091Mu-1x96wellstestplate 1x96-wells test plate
EUR 483.46
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit

SEA091Mu-5x96wellstestplate 5x96-wells test plate
EUR 1875.57
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit

4-SEA091Mu
  • EUR 3460.00
  • EUR 1826.00
  • EUR 484.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Macrophage Derived Chemokine (MDC) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Macrophage-Derived Chemokine, MDC ELISA kit

CSB-E04661m-24T 1 plate of 24 wells
EUR 165
Description: Quantitative sandwich ELISA kit for measuring Mouse Macrophage-Derived Chemokine, MDC in samples from serum, plasma, tissue homogenates, cell culture supernates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Macrophage-Derived Chemokine, MDC ELISA kit

1-CSB-E04661m
  • EUR 602.00
  • EUR 4238.00
  • EUR 2256.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Mouse Macrophage-Derived Chemokine, MDC in samples from serum, plasma, tissue homogenates, cell culture supernates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse)

4-PAA091Mu01
  • EUR 196.00
  • EUR 1704.00
  • EUR 442.00
  • EUR 236.00
  • EUR 191.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC)

Mouse Macrophage Derived Chemokine ELISA Kit (MDC)

RK03021 96 Tests
EUR 521

Mouse Macrophage-Derived Chemokine(MDC)ELISA Kit

GA-E0657MS-48T 48T
EUR 336

Mouse Macrophage-Derived Chemokine(MDC)ELISA Kit

GA-E0657MS-96T 96T
EUR 534

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit

20-abx190440
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Macrophage-Derived Chemokine(MDC)ELISA Kit

QY-E20955 96T
EUR 361

MDC ELISA Kit (Mouse) : 96 Wells (OKAG00094)

OKAG00094 96 Wells
EUR 596
Description: Description of target: Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses.;Species reactivity: Mouse;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 8 pg/mL

Mouse Macrophage-Derived Chemokine,MDC ELISA kit

CN-02438M1 96T
EUR 483

Mouse Macrophage-Derived Chemokine,MDC ELISA kit

CN-02438M2 48T
EUR 333

Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), APC

4-PAA091Mu01-APC
  • EUR 269.00
  • EUR 2177.00
  • EUR 638.00
  • EUR 330.00
  • EUR 186.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with APC.

Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), Biotinylated

4-PAA091Mu01-Biotin
  • EUR 255.00
  • EUR 1654.00
  • EUR 526.00
  • EUR 300.00
  • EUR 194.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with Biotin.

Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), Cy3

4-PAA091Mu01-Cy3
  • EUR 317.00
  • EUR 2861.00
  • EUR 809.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with Cy3.

Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), FITC

4-PAA091Mu01-FITC
  • EUR 235.00
  • EUR 1761.00
  • EUR 530.00
  • EUR 284.00
  • EUR 168.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with FITC.

Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), HRP

4-PAA091Mu01-HRP
  • EUR 249.00
  • EUR 1903.00
  • EUR 569.00
  • EUR 302.00
  • EUR 178.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with HRP.

Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), PE

4-PAA091Mu01-PE
  • EUR 235.00
  • EUR 1761.00
  • EUR 530.00
  • EUR 284.00
  • EUR 168.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with PE.

ELISA kit for Mouse MDC (Macrophage Derived Chemokine)

ELK1114 1 plate of 96 wells
EUR 372
Description: A sandwich ELISA kit for detection of Macrophage Derived Chemokine from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

MDC Macrophage-Derived Chemokine Mouse Recombinant Protein (CCL22)

PROTO88430 Regular: 20ug
EUR 317
Description: CCL22 Mouse Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 68 amino acids and having a molecular mass of 7.8kDa. _x000D_ The Mouse CCL22 is purified by proprietary chromatographic techniques._x000D_

Mouse Macrophage Derived Chemokine / MDC (CCL22) ELISA Kit

abx574514-96tests 96 tests
EUR 637

Mouse Macrophage Derived Chemokine / MDC (CCL22) ELISA Kit

abx050151-96tests 96 tests
EUR 668

Mouse Macrophage-Derived Chemokine /MDC (CCL22) CLIA Kit

abx195329-96tests 96 tests
EUR 825

Mouse Macrophage Derived Chemokine / MDC (CCL22) ELISA Kit

abx254428-96tests 96 tests
EUR 637

Mouse Macrophage Derived Chemokine / MDC (CCL22) ELISA Kit

20-abx154367
  • EUR 5640.00
  • EUR 3009.00
  • EUR 707.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

ELISA kit for Mouse Macrophage-Derived Chemokine,MDC

EK0347 96 tests
EUR 712
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Macrophage-Derived Chemokine,MDC in samples from serum, plasma, tissue homogenates and other biological fluids.

Mouse MDC/CCL22(Macrophage-Derived Chemokine) ELISA Kit

EM0137 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml

Recombinant Mouse CCL22/ MDC Protein, Untagged, E.coli-100ug

QP10276-ec-100ug 100ug
EUR 1178

Recombinant Mouse CCL22/ MDC Protein, Untagged, E.coli-20ug

QP10276-ec-20ug 20ug
EUR 290

Recombinant Mouse CCL22/ MDC Protein, Untagged, E.coli-250ug

QP10276-ec-250ug 250ug
EUR 2067

Recombinant Mouse CCL22/ MDC Protein, Untagged, E.coli-5ug

QP10276-ec-5ug 5ug
EUR 154

Recombinant Macrophage Derived Chemokine (MDC)

4-RPA091Bo01
  • EUR 530.08
  • EUR 245.00
  • EUR 1712.80
  • EUR 637.60
  • EUR 1175.20
  • EUR 418.00
  • EUR 4132.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Bovine Macrophage Derived Chemokine expressed in: E.coli

Recombinant Macrophage Derived Chemokine (MDC)

4-RPA091Ca01
  • EUR 548.00
  • EUR 250.00
  • EUR 1780.00
  • EUR 660.00
  • EUR 1220.00
  • EUR 430.00
  • EUR 4300.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Dog Macrophage Derived Chemokine expressed in: E.coli

Recombinant Macrophage Derived Chemokine (MDC)

4-RPA091Hu01
  • EUR 458.40
  • EUR 226.00
  • EUR 1444.00
  • EUR 548.00
  • EUR 996.00
  • EUR 370.00
  • EUR 3460.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Macrophage Derived Chemokine expressed in: E.coli

Recombinant Macrophage Derived Chemokine (MDC)

4-RPA091Mu01
  • EUR 494.24
  • EUR 235.00
  • EUR 1578.40
  • EUR 592.80
  • EUR 1085.60
  • EUR 394.00
  • EUR 3796.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Macrophage Derived Chemokine expressed in: E.coli

Recombinant Macrophage Derived Chemokine (MDC)

4-RPA091Ra01
  • EUR 496.03
  • EUR 236.00
  • EUR 1585.12
  • EUR 595.04
  • EUR 1090.08
  • EUR 395.00
  • EUR 3812.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Macrophage Derived Chemokine expressed in: E.coli

Recombinant Murine MDC (CCL22) Protein

PROTO88430-1 20ug
EUR 317
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

MDC (69 a.a.), CCL22, human

RC315-33 5ug
EUR 104.38

Anserini MDC/CCL22 ELISA Kit

EAM0217 96Tests
EUR 521

Guinea Pig MDC ELISA Kit

EGM0016 96Tests
EUR 521

Guinea Pig MDC ELISA Kit

EGM0217 96Tests
EUR 521

Macrophage Derived Chemokine (MDC) Antibody

20-abx130146
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Macrophage Derived Chemokine (MDC) Antibody

20-abx104821
  • EUR 453.00
  • EUR 133.00
  • EUR 1288.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Macrophage Derived Chemokine (MDC) Antibody

20-abx104906
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
Conclusion: SSc sufferers who produce autoantibodies to elements of the Th/To advanced have a scientific phenotype characterised by restricted cutaneous illness and pulmonary involvement. Our findings present that the presence of any Th/To autoantibody might have a protecting impact in opposition to contemporaneous most cancers.

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