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Understanding the discrimination and quantification of monoclonal antibodies preparations using Raman spectroscopy

Tara

The usage of Raman spectroscopy for analytical high quality management of anticancer drug preparations in scientific pharmaceutical allotting models is growing in reputation, notably supported by commercially obtainable, objective designed devices. Though not legislatively obligatory, analytical strategies are incessantly used post-preparation to confirm the accuracy of a preparation when it comes to id and amount of the drug in answer. Nonetheless, whereas the fast, price efficient and label free evaluation achieved with Raman spectroscopy is interesting, it is very important perceive the molecular origin of the spectral contributions collected from the answer of actives and excipients, to guage the energy and limitation for the method, which can be utilized to establish and quantify both the prescribed business formulation, and/or the energetic drug itself, in personalised options.

Within the present research, 4 business formulations, Erbitux®, Truxima®, Ontruzant® and Avastin® of monoclonal antibodies (mAbs), corresponding respectively to cetuximab, rituximab, trastuzumab and bevacizumab have been used to focus on the important thing function of excipients in discrimination and quantification of the formulations. It’s demonstrated that protein based mostly anticancer medicine akin to mAbs have a comparatively weak Raman response, whereas excipients akin to glycine, trehalose or histidine contribute considerably to the spectra. Multivariate evaluation (partial least sq. regression and partial least sq. discriminant evaluation) additional demonstrates that the signatures of the mAbs themselves usually are not outstanding in mathematical fashions and that these of the excipients are solely liable for the differentiation of formulation and correct willpower of concentrations.

Whereas Raman spectroscopy can efficiently validate the conformity of mAbs intravenous infusion options, the idea for the evaluation ought to be thought of, and particular warning ought to be given to excipient compositions in business formulations to make sure reliability and reproducibility of the evaluation.

 

Preclinical and Scientific Improvement of Therapeutic Antibodies Concentrating on Features of CD47 within the Tumor Microenvironment

CD47 is a ubiquitously expressed cell floor glycoprotein that capabilities as a signaling receptor for thrombospondin-1 and because the counter-receptor for sign regulatory protein-α (SIRPα). Participating SIRPα on macrophages inhibits phagocytosis, and CD47 thereby serves as a physiological marker of self. Nonetheless, elevated CD47 expression on some most cancers cells additionally protects tumors from innate immune surveillance and limits adaptive antitumor immunity by way of inhibitory SIRPα signaling in antigen presenting cells. CD47 additionally mediates inhibitory thrombospondin-1 signaling in vascular cells, T cells, and NK cells, and blocking inhibitory CD47 signaling on cytotoxic T cells instantly will increase tumor cell killing.
Due to this fact, CD47 capabilities as an innate and adaptive immune checkpoint. These findings have led to the event of antibodies and different therapeutic approaches to dam CD47 capabilities within the tumor microenvironment. Preclinical research in mice demonstrated that blocking CD47 can restrict the expansion of hematologic malignancies and strong tumors and improve the efficacy of standard chemotherapy, radiation remedy, and a few focused most cancers therapies. Humanized CD47 antibodies are displaying promise in early scientific trials, however unwanted effects associated to enhanced phagocytic clearance of circulating blood cells stay a priority. Approaches to bypass these embody antibody preloading methods, growth of antibodies that acknowledge tumor-specific epitopes of CD47, SIRPα antibodies, and bivalent antibodies that limit CD47 blockade to particular tumor cells.
Preclinical and scientific growth of antibodies and associated biologics that inhibit CD47/SIRPα signaling are reviewed, together with methods to mix these brokers with numerous standard and focused therapeutics to enhance affected person end result for numerous cancers.

Most cancers in Systemic Sclerosis: Evaluation of antibodies in opposition to elements of the Th/To Complicated

Goal: The intention of this research is to explain 4 of the commonest autoantibodies in opposition to elements of the Th/To advanced: hPOP1, RPP25, RPP30, and RPP40. We report their prevalence and scientific traits in a systemic sclerosis (SSc) inhabitants, and decide whether or not these specificities affiliate with most cancers.
Strategies: A case management research was carried out using knowledge from the Johns Hopkins Scleroderma Heart Cohort. A complete of 804 grownup sufferers with SSc had been included; 401 SSc sufferers with no historical past of most cancers after a minimum of 5 years of illness had been in comparison with 403 SSc sufferers who ever had a historical past of most cancers. Antibodies in opposition to hPOP1, RPP25, RPP30, and RPP40 had been assayed by immunoprecipitation of 35 S-methionine-labeled proteins generated by in vitro transcription/translation. Demographic and scientific traits had been in contrast between teams.
Outcomes: 67/804 (8.3%) of sufferers had antibodies in opposition to any element of the Th/To advanced. Sufferers with antibodies to any element had been considerably extra more likely to have restricted cutaneous illness, much less more likely to have tendon friction rubs, and extra more likely to have findings in line with interstitial lung illness or pulmonary hypertension. Sufferers with antibodies in opposition to hPOP1, RPP25, RPP30, and/or RPP40 had been considerably much less more likely to develop most cancers inside 2 years of SSc-onset (0% vs 11%, p=0.016).

Mouse MDC (CCL22)
MBS692094-5x002mg 5x0.02mg
EUR 1725

Mouse Monoclonal anti-human CCL-22 (MDC)
hAP-0147 100ug
EUR 250

MDC/CCL22, Mouse
HY-P7248 10ug
EUR 321.6

MDC protein (Mouse)
30R-AM058 20 ug
EUR 312
Description: Purified recombinant Mouse MDC protein

MDC protein (Mouse)
MBS539496-002mg 0.02mg
EUR 465

MDC protein (Mouse)
MBS539496-5x002mg 5x0.02mg
EUR 1945

Anti-Mouse MDC Antibody
103-P66 100 µg
EUR 245.7
Description: Mouse MCD, the mouse orthologue of the human macrophagederived chemokine (MDC)/stimulated T cell chemotactic protein (STCP-1), is a CC chemokine cloned from activated mouse B cells. Mouse MDC cDNA encodes a precursor protein of 92 amino acid (aa) residues with a 24 aa residue predicted signal peptide that is cleaved to yield a 68 aa residue mature 7.8 kDa protein. At the amino acid sequence level, mouse and human MDC share 64% identity and 83% similarity. The genomic organization of the mouse and human MDC genes are very similar, exhibiting sequence identity at the intron-exon boundaries. Mouse MDC is expressed at high levels in dendritic cells and activated B lymphocytes. Low levels of mouse MDC mRNA are also detectable in lung, unstimulated spleen cells, lymph node cells and in thymocytes. MDC is a functional ligand for the CC chemokine receptor 4. Recombinant or chemically synthesized mature mouse MDC has been shown to induce chemotaxis or Ca2+ mobilization in activated mouse and human T cells.

Mouse MDC ELISA Kit
55R-1643 1 kit
EUR 633
Description: ELISA kit for detection of MDC in the research laboratory

Mouse MDC ELISA Kit
EMM0016 96Tests
EUR 625.2

Mouse MDC ELISA Kit
EMM0217 96Tests
EUR 625.2

Mouse MDC ELISA kit
E22-MC105.48 48T
EUR 295
Description: 4pg/ml

Mouse MDC ELISA kit
E22-MC105.96 96T
EUR 395
Description: 4pg/ml

Mouse MDC ELISA Kit
GWB-ZZD104 1x96 well plate Ask for price

Mouse MDC ELISA Kit
GWB-SKR094 96 Tests Ask for price

Mouse MDC ELISA kit
LF-EK50241 1×96T
EUR 777.6

Mouse MDC ELISA Kit
MBS8579383-48Tests 48Tests
EUR 390

Mouse MDC ELISA Kit
MBS8579383-5x96Tests 5x96Tests
EUR 2275

Mouse MDC ELISA Kit
MBS8579383-96Tests 96Tests
EUR 495

Mouse MDC ELISA Kit
MBS9135884-5x96Tests 5x96Tests
EUR 2615

Mouse MDC ELISA Kit
MBS9135884-96Tests 96Tests
EUR 570

Mouse MDC (CCL22) Recombinant
MBS553251-0005mg 0.005mg
EUR 165

Mouse MDC (CCL22) Recombinant
MBS553251-002mg 0.02mg
EUR 245

MDC, CCL22, murine (mouse)
RC335-33 5ug
EUR 125.26

Mouse MDC ELISA kit (4X96T)
LF-EK50242 4×96T
EUR 2641.2

Anti-Human MDC
GWB-BIG6CC 500ug Ask for price

Mouse MDC PicoKine ELISA Kit
MBS175846-5x96StripWells 5x96-Strip-Wells
EUR 2755

Mouse MDC PicoKine ELISA Kit
MBS175846-96StripWells 96-Strip-Wells
EUR 600

Mouse CCL22/MDC ELISA Kit
E28L0315 96T
EUR 666.67

MDC / CCL22 (Mouse) ELISA Kit
MBS495367-5x96Tests 5x96Tests
EUR 3050

MDC / CCL22 (Mouse) ELISA Kit
MBS495367-96Tests 96Tests
EUR 665

MDC / CCL22 Mouse ELISA Kit
MBS355437-5x96Tests 5x96Tests
EUR 2190

MDC / CCL22 Mouse ELISA Kit
MBS355437-96Tests 96Tests
EUR 485

Recombinant Mouse MDC/CCL22 protein
CD00304-5ug 5ug
EUR 176
Description: CCL22 is a protein that in mouse is encoded by the CCL22 gene, which locates on the Chr. 8. It is highly expressed in macrophage, monocyte-derived dendritic cell and thymus, additionally, also detected in the tissues of thymus, lymph node and appendix. CCL22 can bind to CCR4, and is a chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells, but not for neutrophils, eosinophils, and resting T-lymphocytes. After secreted from monocyte-derived dendritic cells, the protein can be proteolytic cleaved into three forms: MDC (3-69), MDC (5-69), MDC (7-69).

Mouse MDC (CCL22) Recombinant Protein
M10-033 20 µg
EUR 196.35
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Mouse MDC (CCL22) Recombinant Protein
M10-033S 5 µg
EUR 92.4
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

MDC ELISA Kit (Mouse) (OKBB00214)
OKBB00214 96 Tests
EUR 621.6
Description: Description of target: Macrophage-derived chemokine (MDC), also called Chemokine, cc motif, ligand 22 (CCL22) or Small inducible cytokine subfamily A, member 22 (SCY22). MDC is a recently identified member of the CC chemokine family. It is not closely related to other chemokines, sharing most similarity with thymus- and activation-regulated chemokine (TARC), which contains 37% identical amino acids. In addition, MDC gene is mapped to chromosome 16q13, the same position reported for the TARC gene. MDC has the four-cysteine motif and other highly conserved residues characteristic of CC chemokines, but it shares <35% identity with any of the known chemokines. Recombinant MDC was expressed in Chinese hamster ovary cells and purified by heparin-Sepharose chromatography. MDC is highly expressed in macrophages and in monocyte-derived dendritic cells, but not in monocytes, natural killer cells, or several cell lines of epithelial, endothelial, or fibroblast origin. High expression was also detected in normal thymus and less expression in lung and spleen. MDC is thus a unique member of the CC chemokine family that may play a fundamental role in the function of dendritic cells, natural killer cells, and monocytes.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 1 pg/mL

Mouse MDC Recombinant Protein Lyophilized
IMSMDCRLY5UG each
EUR 341
Description: Mouse MDC Recombinant Protein Lyophilized

Mouse MDC Recombinant Protein Lyophilized
MBS8434270-INQUIRE INQUIRE Ask for price

MDC (CCL22) mouse monoclonal antibody, Azide Free
PM1208P 500 µg Ask for price

Anti-Human MDC Antibody
102-P61 100 µg
EUR 245.7
Description: MDC or CCL22, also named stimulated T cell chemotactic protein (STCP-1), is a CC chemokine initially isolated from clones of monocyte-derived macrophages. Human MDC cDNA encodes a precursor protein of 93 amino acid residues with a 24 amino acid residue predicted signal peptide that is cleaved to yield a 69 amino acid residue mature 8 kDa protein. At the amino acid sequence level, MDC shows less than 35% identity to other CC chemokine family members. Human MDC is expressed in dendritic cells, macrophages and activated monocytes. In addition, MDC expression is also detected in the tissues of thymus, lymph node and appendix. The gene for human MDC has been mapped to chromosome 16 rather than chromosome 17 where the genes for many human CC chemokines are clustered. Recombinant or chemically synthesized mature MDC has been shown to induce chemotaxis or Ca2+ mobilization in dendritic cells, IL2 activated NK cells, and activated T lymphocytes. A CD8+ T lymphocyte-derived secreted soluble activity that suppresses infection by primary non-syncytium-inducing and syncytium-inducing HIV1 isolates and the T cell line-adapted isolate HIV1 IIIB, has been identified as MDC. Based on aminoterminal sequence analysis, the major CD8 + T lymphocyte-derived MDC protein yielded an aminoterminal sequence of YGANM, which is two amino acid residues shorter than the predicted mature MDC. The difference in potency between the two mature MDC isoforms has not been determined.

Anti-Human MDC Antibody
101-M77 500 µg
EUR 246.75
Description: MDC or CCL22, also named stimulated T cell chemotactic protein (STCP-1), is a CC chemokine initially isolated from clones of monocyte-derived macrophages. Human MDC cDNA encodes a precursor protein of 93 amino acid residues with a 24 amino acid residue predicted signal peptide that is cleaved to yield a 69 amino acid residue mature 8 kDa protein. At the amino acid sequence level, MDC shows less than 35% identity to other CC chemokine family members. Human MDC is expressed in dendritic cells, macrophages and activated monocytes. In addition, MDC expression is also detected in the tissues of thymus, lymph node and appendix. The gene for human MDC has been mapped to chromosome 16 rather than chromosome 17 where the genes for many human CC chemokines are clustered. Recombinant or chemically synthesized mature MDC has been shown to induce chemotaxis or Ca2+ mobilization in dendritic cells, IL2 activated NK cells, and activated T lymphocytes. A CD8+ T lymphocyte-derived secreted soluble activity that suppresses infection by primary non-syncytium-inducing and syncytium-inducing HIV1 isolates and the T cell line-adapted isolate HIV1 IIIB, has been identified as MDC. Based on aminoterminal sequence analysis, the major CD8 + T lymphocyte derived MDC protein yielded an aminoterminal sequence of YGANM, which is two amino acid residues shorter than the predicted mature MDC. The difference in potency between the two mature MDC isoforms has not been determined.

RABBIT ANTI HUMAN MDC
MBS221724-01mg 0.1mg
EUR 635

RABBIT ANTI HUMAN MDC
MBS221724-5x01mg 5x0.1mg
EUR 2695

Anti-Human MDC (CCL22)
MBS550701-01mg 0.1mg
EUR 260

Anti-Human MDC (CCL22)
MBS550701-02mg 0.2mg
EUR 335

Recombinant Mouse MDC/CCL22 (rMuMDC/CCL22)
JOT-PR2006 5µg
EUR 205
Description: Fully biologically active when compared to standard. Determined by its ability to chemoattract human activated lymphocytes using a concentration range of 10.0-100.0 ng/ml, corresponding to a Specific Activity of ＞1 x 104 IU/mg.

Recombinant Mouse MDC/CCL22 (rMuMDC/CCL22)
PR2006 5µg
EUR 158
Description: Fully biologically active when compared to standard. Determined by its ability to chemoattract human activated lymphocytes using a concentration range of 10.0-100.0 ng/ml, corresponding to a Specific Activity of ＞1 x 104 IU/mg.

OKRC01254-96W - MDC ELISA Kit (Mouse)
OKRC01254-96W 96Wells
EUR 525

OKAG00094-96W - MDC ELISA Kit (Mouse)
OKAG00094-96W 1plate:12x8-WellMicrostrips
EUR 475

MDC Protein, Mouse, Recombinant (His Tag)
E45M52627E1-100 100 ug
EUR 941.15

MDC Protein, Mouse, Recombinant (His Tag)
MBS8123162-01mg 0.1mg
EUR 450

MDC Protein, Mouse, Recombinant (His Tag)
MBS8123162-1mg 1mg
EUR 2530

MDC Protein, Mouse, Recombinant (His Tag)
MBS8123162-5x1mg 5x1mg
EUR 11240

Rat Monoclonal anti-mouse CCL-22 (MDC)
mAP-0175 100ug
EUR 250

Macrophage Derived Chemokine, Recombinant, Mouse (MDC)
MBS650601-002mg 0.02mg
EUR 665

Macrophage Derived Chemokine, Recombinant, Mouse (MDC)
MBS650601-5x002mg 5x0.02mg
EUR 2850

Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse)
4-PAA091Mu01
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  • 20ul
  • 100ul
  • 200ul
  • 1ml
  • 10ml
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC)

Mouse Macrophage Derived Chemokine (MDC) Protein
abx067887-100g 100 µg
EUR 575

Mouse Macrophage Derived Chemokine (MDC) Protein
20-abx067887
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  • 10 ug
  • 50 ug
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  • 200 ug
  • 1 mg

Mouse Macrophage Derived Chemokine (MDC) Protein
abx067887-10g 10 µg
EUR 225

Mouse Macrophage Derived Chemokine (MDC) Protein
abx067887-50g 50 µg
EUR 400

MDC ELISA Kit (Mouse) : 96 Wells (OKAG00094)
OKAG00094 96 Wells
EUR 715.2
Description: Description of target: Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses.;Species reactivity: Mouse;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 8 pg/mL

Mouse MDC (Macrophage Derived Chemokine) ELISA Kit
MBS8800116-10x96StripWells 10x96-Strip-Wells
EUR 3130

Mouse MDC (Macrophage Derived Chemokine) ELISA Kit
MBS8800116-48StripWells 48-Strip-Wells
EUR 315

Mouse MDC (Macrophage Derived Chemokine) ELISA Kit
MBS8800116-5x96StripWells 5x96-Strip-Wells
EUR 1710

Mouse MDC (Macrophage Derived Chemokine) ELISA Kit
MBS8800116-96StripWells 96-Strip-Wells
EUR 385

Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), PE
4-PAA091Mu01-PE
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  • 20ul
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  • 200ul
  • 1ml
  • 10ml
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with PE.

Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), APC
4-PAA091Mu01-APC
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  • 20ul
  • 100ul
  • 200ul
  • 1ml
  • 10ml
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with APC.

Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), Cy3
4-PAA091Mu01-Cy3
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  • 20ul
  • 100ul
  • 200ul
  • 1ml
  • 10ml
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with Cy3.

Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), HRP
4-PAA091Mu01-HRP
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  • 20ul
  • 100ul
  • 200ul
  • 1ml
  • 10ml
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with HRP.

Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), FITC
4-PAA091Mu01-FITC
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  • 20ul
  • 100ul
  • 200ul
  • 1ml
  • 10ml
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with FITC.

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
EKU08822-48T 48T
EUR 685.72

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
EKU08822-5x96T 5x96T
EUR 4653.1

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
EKU08822-96T 96T
EUR 979.6

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
EKN49933-48T 48T
EUR 426.72

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
EKN49933-5x96T 5x96T
EUR 2895.6

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
EKN49933-96T 96T
EUR 609.6

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
MBS2708618-10x96StripWells 10x96-Strip-Wells
EUR 3840

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
MBS2708618-24StripWells 24-Strip-Wells
EUR 280

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
MBS2708618-48StripWells 48-Strip-Wells
EUR 375

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
MBS2708618-5x96StripWells 5x96-Strip-Wells
EUR 1985

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
MBS2708618-96StripWells 96-Strip-Wells
EUR 490

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
MBS2025230-10x96StripWells 10x96-Strip-Wells
EUR 6315

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
MBS2025230-24StripWells 24-Strip-Wells
EUR 415

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
MBS2025230-48StripWells 48-Strip-Wells
EUR 640

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
MBS2025230-5x96StripWells 5x96-Strip-Wells
EUR 3480

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
MBS2025230-96StripWells 96-Strip-Wells
EUR 865

Mouse Macrophage Derived Chemokine (MDC)CLIA Kit
SCA091Mu-10x96wellstestplate 10x96-wells test plate
EUR 6965.86
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Macrophage Derived Chemokine (MDC)CLIA Kit
SCA091Mu-1x48wellstestplate 1x48-wells test plate
EUR 678.84
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Macrophage Derived Chemokine (MDC)CLIA Kit
SCA091Mu-1x96wellstestplate 1x96-wells test plate
EUR 918.34
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Macrophage Derived Chemokine (MDC)CLIA Kit
SCA091Mu-5x96wellstestplate 5x96-wells test plate
EUR 3772.51
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Macrophage Derived Chemokine (MDC) CLIA Kit
4-SCA091Mu
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  • 1 plate of 96 wells
  • 5 plates of 96 wells
  • 10 plates of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
DLR-MDC-Mu 96T
EUR 317
Description: serum, plasma or other biological fluids.

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
DLR-MDC-Mu-48T 48T
EUR 462
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Macrophage Derived Chemokine (MDC) in samples from serum, plasma or other biological fluids.

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
DLR-MDC-Mu-96T 96T
EUR 590.4
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Macrophage Derived Chemokine (MDC) in samples from serum, plasma or other biological fluids.

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
DL-MDC-Mu 96T
EUR 302
Description: serum, plasma or other biological fluids.

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
EKU05741-48T 48T
EUR 395.36

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
EKU05741-5x96T 5x96T
EUR 2682.8

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
EKU05741-96T 96T
EUR 564.8

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
EKU11217-48T 48T
EUR 474.74

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
EKU11217-5x96T 5x96T
EUR 3221.45

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
EKU11217-96T 96T
EUR 678.2

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
EK15392 96Т
EUR 768

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
EKN46852-48T 48T
EUR 269.71

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
EKN46852-5x96T 5x96T
EUR 1830.18

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
EKN46852-96T 96T
EUR 385.3

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
EKN52328-48T 48T
EUR 295.33

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
EKN52328-5x96T 5x96T
EUR 2004.03

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
EKN52328-96T 96T
EUR 421.9

Mouse Macrophage Derived Chemokine (MDC) ELISA kit
EIA06028m each
EUR 480

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS4500965-10x96Tests 10x96Tests
EUR 3885

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS4500965-48Tests 48Tests
EUR 350

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS4500965-5x96Tests 5x96Tests
EUR 1990

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS4500965-96Test 96Test
EUR 450

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS454691-10x96StripWells 10x96-Strip-Wells
EUR 3740

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS454691-48StripWells 48-Strip-Wells
EUR 345

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS454691-5x96StripWells 5x96-Strip-Wells
EUR 1915

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS454691-96StripWells 96-Strip-Wells
EUR 435

Mouse Macrophage Derived Chemokine (MDC) ELISA kit
MBS264933-10x96StripWells 10x96-Strip-Wells
EUR 3290

Mouse Macrophage Derived Chemokine (MDC) ELISA kit
MBS264933-48StripWells 48-Strip-Wells
EUR 295

Mouse Macrophage Derived Chemokine (MDC) ELISA kit
MBS264933-5x96StripWells 5x96-Strip-Wells
EUR 1800

Mouse Macrophage Derived Chemokine (MDC) ELISA kit
MBS264933-96StripWells 96-Strip-Wells
EUR 450

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS2022508-10x96StripWells 10x96-Strip-Wells
EUR 4070

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS2022508-24StripWells 24-Strip-Wells
EUR 295

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS2022508-48StripWells 48-Strip-Wells
EUR 420

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS2022508-5x96StripWells 5x96-Strip-Wells
EUR 2225

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS2022508-96StripWells 96-Strip-Wells
EUR 550

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS2701143-10x96StripWells 10x96-Strip-Wells
EUR 2275

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS2701143-24StripWells 24-Strip-Wells
EUR 225

Mouse Macrophage Derived Chemokine (MDC) ELISA Kit
MBS2701143-48StripWells 48-Strip-Wells
EUR 280
Conclusion: SSc sufferers who produce autoantibodies to elements of the Th/To advanced have a scientific phenotype characterised by restricted cutaneous illness and pulmonary involvement. Our findings present that the presence of any Th/To autoantibody might have a protecting impact in opposition to contemporaneous most cancers.
Tara

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