The usage of Raman spectroscopy for analytical high quality management of anticancer drug preparations in scientific pharmaceutical allotting models is growing in reputation, notably supported by commercially obtainable, objective designed devices. Though not legislatively obligatory, analytical strategies are incessantly used post-preparation to confirm the accuracy of a preparation when it comes to id and amount of the drug in answer. Nonetheless, whereas the fast, price efficient and label free evaluation achieved with Raman spectroscopy is interesting, it is very important perceive the molecular origin of the spectral contributions collected from the answer of actives and excipients, to guage the energy and limitation for the method, which can be utilized to establish and quantify both the prescribed business formulation, and/or the energetic drug itself, in personalised options.
Within the present research, 4 business formulations, Erbitux®, Truxima®, Ontruzant® and Avastin® of monoclonal antibodies (mAbs), corresponding respectively to cetuximab, rituximab, trastuzumab and bevacizumab have been used to focus on the important thing function of excipients in discrimination and quantification of the formulations. It’s demonstrated that protein based mostly anticancer medicine akin to mAbs have a comparatively weak Raman response, whereas excipients akin to glycine, trehalose or histidine contribute considerably to the spectra. Multivariate evaluation (partial least sq. regression and partial least sq. discriminant evaluation) additional demonstrates that the signatures of the mAbs themselves usually are not outstanding in mathematical fashions and that these of the excipients are solely liable for the differentiation of formulation and correct willpower of concentrations.
Whereas Raman spectroscopy can efficiently validate the conformity of mAbs intravenous infusion options, the idea for the evaluation ought to be thought of, and particular warning ought to be given to excipient compositions in business formulations to make sure reliability and reproducibility of the evaluation.
Preclinical and Scientific Improvement of Therapeutic Antibodies Concentrating on Features of CD47 within the Tumor Microenvironment
CD47 is a ubiquitously expressed cell floor glycoprotein that capabilities as a signaling receptor for thrombospondin-1 and because the counter-receptor for sign regulatory protein-α (SIRPα). Participating SIRPα on macrophages inhibits phagocytosis, and CD47 thereby serves as a physiological marker of self. Nonetheless, elevated CD47 expression on some most cancers cells additionally protects tumors from innate immune surveillance and limits adaptive antitumor immunity by way of inhibitory SIRPα signaling in antigen presenting cells. CD47 additionally mediates inhibitory thrombospondin-1 signaling in vascular cells, T cells, and NK cells, and blocking inhibitory CD47 signaling on cytotoxic T cells instantly will increase tumor cell killing.
Due to this fact, CD47 capabilities as an innate and adaptive immune checkpoint. These findings have led to the event of antibodies and different therapeutic approaches to dam CD47 capabilities within the tumor microenvironment. Preclinical research in mice demonstrated that blocking CD47 can restrict the expansion of hematologic malignancies and strong tumors and improve the efficacy of standard chemotherapy, radiation remedy, and a few focused most cancers therapies. Humanized CD47 antibodies are displaying promise in early scientific trials, however unwanted effects associated to enhanced phagocytic clearance of circulating blood cells stay a priority. Approaches to bypass these embody antibody preloading methods, growth of antibodies that acknowledge tumor-specific epitopes of CD47, SIRPα antibodies, and bivalent antibodies that limit CD47 blockade to particular tumor cells.
Preclinical and scientific growth of antibodies and associated biologics that inhibit CD47/SIRPα signaling are reviewed, together with methods to mix these brokers with numerous standard and focused therapeutics to enhance affected person end result for numerous cancers.
Most cancers in Systemic Sclerosis: Evaluation of antibodies in opposition to elements of the Th/To Complicated
Goal: The intention of this research is to explain 4 of the commonest autoantibodies in opposition to elements of the Th/To advanced: hPOP1, RPP25, RPP30, and RPP40. We report their prevalence and scientific traits in a systemic sclerosis (SSc) inhabitants, and decide whether or not these specificities affiliate with most cancers.
Strategies: A case management research was carried out using knowledge from the Johns Hopkins Scleroderma Heart Cohort. A complete of 804 grownup sufferers with SSc had been included; 401 SSc sufferers with no historical past of most cancers after a minimum of 5 years of illness had been in comparison with 403 SSc sufferers who ever had a historical past of most cancers. Antibodies in opposition to hPOP1, RPP25, RPP30, and RPP40 had been assayed by immunoprecipitation of 35 S-methionine-labeled proteins generated by in vitro transcription/translation. Demographic and scientific traits had been in contrast between teams.
Outcomes: 67/804 (8.3%) of sufferers had antibodies in opposition to any element of the Th/To advanced. Sufferers with antibodies to any element had been considerably extra more likely to have restricted cutaneous illness, much less more likely to have tendon friction rubs, and extra more likely to have findings in line with interstitial lung illness or pulmonary hypertension. Sufferers with antibodies in opposition to hPOP1, RPP25, RPP30, and/or RPP40 had been considerably much less more likely to develop most cancers inside 2 years of SSc-onset (0% vs 11%, p=0.016).
 Mouse MDC ELISA Kit |
|
EMM0217 |
Abclonal |
96Tests |
EUR 625.2 |
 Mouse MDC ELISA kit |
|
LF-EK50241 |
Abfrontier |
1×96T |
EUR 777.6 |
Mouse MDC ELISA Kit |
|
RK00184 |
Abclonal |
96 Tests |
EUR 625.2 |
) MDC, CCL22, murine (mouse) |
|
RC335-33 |
Bio Basic |
5ug |
EUR 125.26 |
|
|
) Mouse MDC ELISA kit (4X96T) |
|
LF-EK50242 |
Abfrontier |
4×96T |
EUR 2641.2 |
 Mouse MDC PicoKine ELISA Kit |
|
EK0447 |
BosterBio |
96 wells |
EUR 523.2 |
|
Description: For quantitative detection of mouse MDC in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
 (OKBB00214)) MDC ELISA Kit (Mouse) (OKBB00214) |
|
OKBB00214 |
Aviva Systems Biology |
96 Tests |
EUR 621.6 |
|
Description: Description of target: Macrophage-derived chemokine (MDC), also called Chemokine, cc motif, ligand 22 (CCL22) or Small inducible cytokine subfamily A, member 22 (SCY22). MDC is a recently identified member of the CC chemokine family. It is not closely related to other chemokines, sharing most similarity with thymus- and activation-regulated chemokine (TARC), which contains 37% identical amino acids. In addition, MDC gene is mapped to chromosome 16q13, the same position reported for the TARC gene. MDC has the four-cysteine motif and other highly conserved residues characteristic of CC chemokines, but it shares <35% identity with any of the known chemokines. Recombinant MDC was expressed in Chinese hamster ovary cells and purified by heparin-Sepharose chromatography. MDC is highly expressed in macrophages and in monocyte-derived dendritic cells, but not in monocytes, natural killer cells, or several cell lines of epithelial, endothelial, or fibroblast origin. High expression was also detected in normal thymus and less expression in lung and spleen. MDC is thus a unique member of the CC chemokine family that may play a fundamental role in the function of dendritic cells, natural killer cells, and monocytes.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 1 pg/mL |
 MDC antibody |
|
10R-M168A |
Fitzgerald |
500 ug |
EUR 327.6 |
|
Description: Mouse monoclonal MDC antibody |
MDC antibody |
|
20R-1805 |
Fitzgerald |
100 ug |
EUR 807.6 |
|
Description: Rabbit polyclonal MDC antibody |
MDC antibody |
|
70R-MR020 |
Fitzgerald |
50 ug |
EUR 327.6 |
|
Description: Affinity purified Rabbit polyclonal MDC antibody |
MDC antibody |
|
70R-MR031 |
Fitzgerald |
50 ug |
EUR 327.6 |
|
Description: Affinity purified Rabbit polyclonal MDC antibody |
 MDC Antibody |
|
5531-100 |
Biovision |
each |
EUR 405.6 |
MDC antibody |
|
70R-12355 |
Fitzgerald |
100 ug |
EUR 536.4 |
|
Description: Rabbit polyclonal MDC antibody |
 Polyclonal Antibody (Mouse)) Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse) |
|
4-PAA091Mu01 |
Cloud-Clone |
-
EUR 235.20
-
EUR 2044.80
-
EUR 530.40
-
EUR 283.20
-
EUR 229.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC) |
 Protein) Mouse Macrophage Derived Chemokine (MDC) Protein |
|
20-abx067887 |
Abbexa |
-
EUR 828.00
-
EUR 343.20
-
EUR 2548.80
-
EUR 978.00
-
EUR 594.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
 : 96 Wells (OKAG00094)) MDC ELISA Kit (Mouse) : 96 Wells (OKAG00094) |
|
OKAG00094 |
Aviva Systems Biology |
96 Wells |
EUR 715.2 |
|
Description: Description of target: Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses.;Species reactivity: Mouse;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 8 pg/mL |
 Polyclonal Antibody (Mouse), PE) Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), PE |
|
4-PAA091Mu01-PE |
Cloud-Clone |
-
EUR 282.00
-
EUR 2113.20
-
EUR 636.00
-
EUR 340.80
-
EUR 201.60
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with PE. |
 Polyclonal Antibody (Mouse), APC) Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), APC |
|
4-PAA091Mu01-APC |
Cloud-Clone |
-
EUR 322.80
-
EUR 2612.40
-
EUR 765.60
-
EUR 396.00
-
EUR 223.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with APC. |
 Polyclonal Antibody (Mouse), Cy3) Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), Cy3 |
|
4-PAA091Mu01-Cy3 |
Cloud-Clone |
-
EUR 380.40
-
EUR 3433.20
-
EUR 970.80
-
EUR 477.60
-
EUR 247.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with Cy3. |
 Polyclonal Antibody (Mouse), HRP) Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), HRP |
|
4-PAA091Mu01-HRP |
Cloud-Clone |
-
EUR 298.80
-
EUR 2283.60
-
EUR 682.80
-
EUR 362.40
-
EUR 213.60
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with HRP. |
 Polyclonal Antibody (Mouse), FITC) Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), FITC |
|
4-PAA091Mu01-FITC |
Cloud-Clone |
-
EUR 282.00
-
EUR 2113.20
-
EUR 636.00
-
EUR 340.80
-
EUR 201.60
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with FITC. |
 CLIA Kit) Mouse Macrophage Derived Chemokine (MDC) CLIA Kit |
|
20-abx190440 |
Abbexa |
-
EUR 9567.60
-
EUR 5095.20
-
EUR 1177.20
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
|
CLIA Kit) Mouse Macrophage Derived Chemokine (MDC)CLIA Kit |
|
SCA091Mu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 6965.86 |
|
|
|
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Macrophage Derived Chemokine (MDC)CLIA Kit |
|
SCA091Mu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 678.84 |
|
|
|
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Macrophage Derived Chemokine (MDC)CLIA Kit |
|
SCA091Mu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 918.34 |
|
|
|
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Macrophage Derived Chemokine (MDC)CLIA Kit |
|
SCA091Mu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 3772.51 |
|
|
|
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Macrophage Derived Chemokine (MDC) CLIA Kit |
|
4-SCA091Mu |
Cloud-Clone |
-
EUR 7026.00
-
EUR 3772.80
-
EUR 919.20
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
|
|
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Mouse Macrophage Derived Chemokine (MDC)Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids |
 ELISA Kit) Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
DLR-MDC-Mu-48T |
DL Develop |
48T |
EUR 462 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Macrophage Derived Chemokine (MDC) in samples from serum, plasma or other biological fluids. |
Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
DLR-MDC-Mu-96T |
DL Develop |
96T |
EUR 590.4 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Macrophage Derived Chemokine (MDC) in samples from serum, plasma or other biological fluids. |
Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
RD-MDC-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 446.4 |
Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
RD-MDC-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 612 |
Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
RDR-MDC-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 465.6 |
Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
RDR-MDC-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 639.6 |
) Mouse Macrophage Derived Chemokine ELISA Kit (MDC) |
|
RK03021 |
Abclonal |
96 Tests |
EUR 625.2 |
Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
SEA091Mu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 4091.29 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
SEA091Mu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 442.1 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
SEA091Mu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 580.15 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
SEA091Mu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2250.68 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Macrophage Derived Chemokine (MDC) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. |
Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
4-SEA091Mu |
Cloud-Clone |
-
EUR 4152.00
-
EUR 2191.20
-
EUR 580.80
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Macrophage Derived Chemokine (MDC) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. |
 Mouse Macrophage-Derived Chemokine, MDC ELISA kit |
|
CSB-E04661m-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
|
|
Description: Quantitative sandwich ELISA kit for measuring Mouse Macrophage-Derived Chemokine, MDC in samples from serum, plasma, tissue homogenates, cell culture supernates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse Macrophage-Derived Chemokine, MDC ELISA kit |
|
1-CSB-E04661m |
Cusabio |
-
EUR 722.40
-
EUR 5085.60
-
EUR 2707.20
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
|
|
Description: Quantitative sandwich ELISA kit for measuring Mouse Macrophage-Derived Chemokine, MDC in samples from serum, plasma, tissue homogenates, cell culture supernates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
 Mouse Macrophage-Derived Chemokine,MDC ELISA kit |
|
CN-02438M1 |
ChemNorm |
96T |
EUR 579.6 |
Mouse Macrophage-Derived Chemokine,MDC ELISA kit |
|
CN-02438M2 |
ChemNorm |
48T |
EUR 399.6 |
ELISA Kit) Mouse Macrophage-Derived Chemokine(MDC)ELISA Kit |
|
GA-E0657MS-48T |
GenAsia Biotech |
48T |
EUR 403.2 |
Mouse Macrophage-Derived Chemokine(MDC)ELISA Kit |
|
GA-E0657MS-96T |
GenAsia Biotech |
96T |
EUR 640.8 |
 Polyclonal Antibody (Mouse), Biotinylated) Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), Biotinylated |
|
4-PAA091Mu01-Biotin |
Cloud-Clone |
-
EUR 306.00
-
EUR 1984.80
-
EUR 631.20
-
EUR 360.00
-
EUR 232.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with Biotin. |
) ELISA kit for Mouse MDC (Macrophage Derived Chemokine) |
|
ELK1114 |
ELK Biotech |
1 plate of 96 wells |
EUR 446.4 |
|
|
|
Description: A sandwich ELISA kit for detection of Macrophage Derived Chemokine from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
 ELISA Kit) Mouse MDC/CCL22(Macrophage-Derived Chemokine) ELISA Kit |
|
EM0137 |
FN Test |
96T |
EUR 628.92 |
|
|
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml |
 Polyclonal Antibody (Mouse), APC-Cy7) Macrophage Derived Chemokine (MDC) Polyclonal Antibody (Mouse), APC-Cy7 |
|
4-PAA091Mu01-APC-Cy7 |
Cloud-Clone |
-
EUR 501.60
-
EUR 5080.80
-
EUR 1387.20
-
EUR 648.00
-
EUR 302.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Macrophage Derived Chemokine (MDC). This antibody is labeled with APC-Cy7. |
 ELISA Kit) Mouse Macrophage Derived Chemokine / MDC (CCL22) ELISA Kit |
|
abx254428-96tests |
Abbexa |
96 tests |
EUR 764.4 |
|
|
Mouse Macrophage Derived Chemokine / MDC (CCL22) ELISA Kit |
|
20-abx154367 |
Abbexa |
-
EUR 6768.00
-
EUR 3610.80
-
EUR 848.40
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
|
Mouse Macrophage Derived Chemokine / MDC (CCL22) ELISA Kit |
|
abx050151-96tests |
Abbexa |
96 tests |
EUR 801.6 |
|
|
Mouse Macrophage Derived Chemokine / MDC (CCL22) ELISA Kit |
|
abx574514-96tests |
Abbexa |
96 tests |
EUR 764.4 |
|
|
 ELISA kit for Mouse Macrophage-Derived Chemokine,MDC |
|
EK0347 |
SAB |
96 tests |
EUR 854.4 |
|
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Macrophage-Derived Chemokine,MDC in samples from serum, plasma, tissue homogenates and other biological fluids. |
 CLIA Kit) Mouse Macrophage-Derived Chemokine /MDC (CCL22) CLIA Kit |
|
abx195329-96tests |
Abbexa |
96 tests |
EUR 990 |
|
|
 Recombinant Mouse CCL22/ MDC Protein, Untagged, E.coli-5ug |
|
QP10276-ec-5ug |
EnQuireBio |
5ug |
EUR 184.8 |
 Recombinant Mouse CCL22/ MDC Protein, Untagged, E.coli-20ug |
|
QP10276-ec-20ug |
EnQuireBio |
20ug |
EUR 348 |
 Recombinant Mouse CCL22/ MDC Protein, Untagged, E.coli-100ug |
|
QP10276-ec-100ug |
EnQuireBio |
100ug |
EUR 1413.6 |
 Recombinant Mouse CCL22/ MDC Protein, Untagged, E.coli-250ug |
|
QP10276-ec-250ug |
EnQuireBio |
250ug |
EUR 2480.4 |
) CLIA kit for Mouse MDC/CCL22 (Macrophage-Derived Chemokine) |
|
E-CL-M0013 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 700.8 |
|
|
|
Description: A sandwich CLIA kit for quantitative measurement of Mouse MDC/CCL22 (Macrophage-Derived Chemokine) in samples from Serum, Plasma, Cell supernatant |
) ELISA kit for Mouse MDC/CCL22 (Macrophage-Derived Chemokine) |
|
E-EL-M0014 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 640.8 |
|
|
|
Description: A sandwich ELISA kit for quantitative measurement of Mouse MDC/CCL22 (Macrophage-Derived Chemokine) in samples from Serum, Plasma, Cell supernatant |
) MDC Macrophage-Derived Chemokine Mouse Recombinant Protein (CCL22) |
|
PROTO88430 |
BosterBio |
Regular: 20ug |
EUR 380.4 |
|
Description: CCL22 Mouse Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 68 amino acids and having a molecular mass of 7.8kDa. _x000D_ The Mouse CCL22 is purified by proprietary chromatographic techniques._x000D_ |
 MDC, CCL22, rat |
|
RC355-33 |
Bio Basic |
5ug |
EUR 125.26 |
|
|
 ELISA Kit) Mini Samples Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
MEA091Mu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 4876.69 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mini Samples Mouse Macrophage Derived Chemokine (MDC). |
Mini Samples Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
MEA091Mu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 506.78 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mini Samples Mouse Macrophage Derived Chemokine (MDC). |
Mini Samples Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
MEA091Mu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 672.55 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mini Samples Mouse Macrophage Derived Chemokine (MDC). |
Mini Samples Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
MEA091Mu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2666.48 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mini Samples Mouse Macrophage Derived Chemokine (MDC). |
Mini Samples Mouse Macrophage Derived Chemokine (MDC) ELISA Kit |
|
4-MEA091Mu |
Cloud-Clone |
-
EUR 4936.80
-
EUR 2607.60
-
EUR 673.20
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mini Samples Mouse Macrophage Derived Chemokine (MDC) in samples from n/a with no significant corss-reactivity with analogues from other species. |
 MDC, human recombinant |
|
4617-100 |
Biovision |
each |
EUR 836.4 |
MDC, human recombinant |
|
4617-1000 |
Biovision |
each |
EUR 3909.6 |
MDC, human recombinant |
|
4617-20 |
Biovision |
each |
EUR 301.2 |
 MDC Recombinant Protein |
|
40-350-0005mg |
ProSci |
0.005 mg |
EUR 311.1 |
|
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. |
MDC Recombinant Protein |
|
40-350-002mg |
ProSci |
0.02 mg |
EUR 437.1 |
|
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. |
MDC Recombinant Protein |
|
40-387-0005mg |
ProSci |
0.005 mg |
EUR 311.1 |
|
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.0 kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. |
MDC Recombinant Protein |
|
40-387-002mg |
ProSci |
0.02 mg |
EUR 437.1 |
|
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.0 kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. |
MDC Recombinant Protein |
|
40-388-0005mg |
ProSci |
0.005 mg |
EUR 311.1 |
|
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.1 kDa protein containing 69 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. |
MDC Recombinant Protein |
|
40-388-002mg |
ProSci |
0.02 mg |
EUR 437.1 |
|
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.1 kDa protein containing 69 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. |
 MDC/CCL22 ELISA Kit| Mouse Macrophage-Derived Chemokine ELISA Ki |
|
EF012892 |
Lifescience Market |
96 Tests |
EUR 826.8 |
 Rat MDC ELISA Kit |
|
ERM0016 |
Abclonal |
96Tests |
EUR 625.2 |
Rat MDC ELISA Kit |
|
ERM0217 |
Abclonal |
96Tests |
EUR 625.2 |
 Goat MDC ELISA Kit |
|
EGTM0016 |
Abclonal |
96Tests |
EUR 625.2 |
Goat MDC ELISA Kit |
|
EGTM0217 |
Abclonal |
96Tests |
EUR 625.2 |
 Human MDC ELISA Kit |
|
55R-1642 |
Fitzgerald |
1 kit |
EUR 660 |
|
Description: ELISA kit for detection of MDC in the research laboratory |
 Human MDC ELISA kit |
|
55R-2065 |
Fitzgerald |
96 tests |
EUR 854.4 |
|
Description: ELISA Kit for detection of MDC in the research laboratory |
 Sheep MDC ELISA Kit |
|
ESM0217 |
Abclonal |
96Tests |
EUR 625.2 |
Human MDC ELISA kit |
|
LF-EK50237 |
Abfrontier |
1×96T |
EUR 777.6 |
Human MDC ELISA Kit |
|
EHM0016 |
Abclonal |
96Tests |
EUR 625.2 |
Human MDC ELISA Kit |
|
EHM0217 |
Abclonal |
96Tests |
EUR 625.2 |
 Rabbit MDC ELISA Kit |
|
ERTM0016 |
Abclonal |
96Tests |
EUR 625.2 |
Rabbit MDC ELISA Kit |
|
ERTM0217 |
Abclonal |
96Tests |
EUR 625.2 |
 Monkey MDC ELISA Kit |
|
EMKM0217 |
Abclonal |
96Tests |
EUR 625.2 |
 Bovine MDC ELISA Kit |
|
EBM0016 |
Abclonal |
96Tests |
EUR 625.2 |
Bovine MDC ELISA Kit |
|
EBM0217 |
Abclonal |
96Tests |
EUR 625.2 |
 Canine MDC ELISA Kit |
|
ECM0016 |
Abclonal |
96Tests |
EUR 625.2 |
Canine MDC ELISA Kit |
|
ECM0217 |
Abclonal |
96Tests |
EUR 625.2 |
 Porcine MDC ELISA Kit |
|
EPM0016 |
Abclonal |
96Tests |
EUR 625.2 |
Porcine MDC ELISA Kit |
|
EPM0217 |
Abclonal |
96Tests |
EUR 625.2 |
 Chicken MDC ELISA Kit |
|
ECKM0217 |
Abclonal |
96Tests |
EUR 625.2 |
 Antibody) Macrophage Derived Chemokine (MDC) Antibody |
|
20-abx270114 |
Abbexa |
-
EUR 560.40
-
EUR 644.40
-
EUR 326.40
-
EUR 978.00
-
EUR 427.20
|
- 100 tests
- 200 tests
- 25 tests
- 500 tests
- 50 tests
|
|
|
Macrophage Derived Chemokine (MDC) Antibody |
|
20-abx104821 |
Abbexa |
-
EUR 543.60
-
EUR 159.60
-
EUR 1545.60
-
EUR 744.00
-
EUR 410.40
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
Macrophage Derived Chemokine (MDC) Antibody |
|
20-abx102775 |
Abbexa |
-
EUR 376.80
-
EUR 159.60
-
EUR 994.80
-
EUR 510.00
-
EUR 326.40
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
Macrophage Derived Chemokine (MDC) Antibody |
|
20-abx102776 |
Abbexa |
-
EUR 376.80
-
EUR 159.60
-
EUR 1011.60
-
EUR 526.80
-
EUR 326.40
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
Macrophage Derived Chemokine (MDC) Antibody |
|
20-abx104906 |
Abbexa |
-
EUR 526.80
-
EUR 159.60
-
EUR 1479.60
-
EUR 710.40
-
EUR 393.60
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
Macrophage Derived Chemokine (MDC) Antibody |
|
20-abx173417 |
Abbexa |
|
|
|
|
Macrophage Derived Chemokine (MDC) Antibody |
|
20-abx173418 |
Abbexa |
|
|
|
|
Macrophage Derived Chemokine (MDC) Antibody |
|
20-abx173419 |
Abbexa |
|
|
|
|
Macrophage Derived Chemokine (MDC) Antibody |
|
20-abx177416 |
Abbexa |
|
|
|
|
Macrophage Derived Chemokine (MDC) Antibody |
|
20-abx131766 |
Abbexa |
-
EUR 376.80
-
EUR 910.80
-
EUR 493.20
-
EUR 184.80
-
EUR 292.80
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
Macrophage Derived Chemokine (MDC) Antibody |
|
20-abx130146 |
Abbexa |
-
EUR 510.00
-
EUR 159.60
-
EUR 1412.40
-
EUR 693.60
-
EUR 393.60
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
 Anserini MDC ELISA Kit |
|
EAM0016 |
Abclonal |
96Tests |
EUR 625.2 |
 MDC/CCL22, murine recombinant |
|
7169-10 |
Biovision |
each |
EUR 248.4 |
MDC/CCL22, murine recombinant |
|
7169-50 |
Biovision |
each |
EUR 810 |
, CCL22, human) MDC (69 a.a.), CCL22, human |
|
RC315-33 |
Bio Basic |
5ug |
EUR 125.26 |
|
|
 Antibody (PE)) Macrophage Derived Chemokine (MDC) Antibody (PE) |
|
20-abx270876 |
Abbexa |
-
EUR 727.20
-
EUR 861.60
-
EUR 393.60
-
EUR 1362.00
-
EUR 526.80
|
- 100 tests
- 200 tests
- 25 tests
- 500 tests
- 50 tests
|
|
|
 Antibody (APC)) Macrophage Derived Chemokine (MDC) Antibody (APC) |
|
20-abx270644 |
Abbexa |
-
EUR 844.80
-
EUR 994.80
-
EUR 444.00
-
EUR 1596.00
-
EUR 594.00
|
- 100 tests
- 200 tests
- 25 tests
- 500 tests
- 50 tests
|
|
|
 Antibody (FITC)) Macrophage Derived Chemokine (MDC) Antibody (FITC) |
|
20-abx270412 |
Abbexa |
-
EUR 627.60
-
EUR 727.20
-
EUR 360.00
-
EUR 1128.00
-
EUR 460.80
|
- 100 tests
- 200 tests
- 25 tests
- 500 tests
- 50 tests
|
|
|
 Antibody Pair) Macrophage Derived Chemokine (MDC) Antibody Pair |
|
20-abx370143 |
Abbexa |
|
- 10 × 96 tests
- 5 × 96 tests
|
|
|
Macrophage Derived Chemokine (MDC) Antibody Pair |
|
20-abx370157 |
Abbexa |
|
- 10 × 96 tests
- 5 × 96 tests
|
|
|
Macrophage Derived Chemokine (MDC) Antibody Pair |
|
20-abx370444 |
Abbexa |
|
- 10 × 96 tests
- 5 × 96 tests
|
|
|
 Guinea Pig MDC ELISA Kit |
|
EGM0016 |
Abclonal |
96Tests |
EUR 625.2 |
Guinea Pig MDC ELISA Kit |
|
EGM0217 |
Abclonal |
96Tests |
EUR 625.2 |
) CCL22/MDC protein (His tag) |
|
80R-1202 |
Fitzgerald |
100 ug |
EUR 268.8 |
|
Description: Purified recombinant Human CCL22/MDC protein |
Conclusion: SSc sufferers who produce autoantibodies to elements of the Th/To advanced have a scientific phenotype characterised by restricted cutaneous illness and pulmonary involvement. Our findings present that the presence of any Th/To autoantibody might have a protecting impact in opposition to contemporaneous most cancers.
