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In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry

Pretargeted imaging has emerged as an efficient multistep technique aiming to enhance imaging distinction and scale back affected person radiation publicity by decoupling of the radioactivity from the focusing on vector. The inverse electron-demand Diels-Alder (IEDDA) response between a trans-cyclooctene (TCO)-conjugated antibody and a labeled tetrazine holds nice promise for pretargeted imaging purposes because of its bioorthogonality, fast kinetics underneath delicate circumstances, and formation of steady merchandise. Herein, we describe using functionalized carbonylacrylic reagents for site-specific incorporation of TCO onto a human epidermal development issue receptor 2 (HER2) antibody (THIOMAB) containing an engineered unpaired cysteine residue, producing homogeneous conjugates. Exact labeling of THIOMAB-TCO with a fluorescent or radiolabeled tetrazine revealed the potential of the TCO-functionalized antibody for imaging the HER2 after pretargeting in a mobile context in a HER2 optimistic breast most cancers cell line.

Management research with MDA-MD-231 cells, which don’t categorical HER2, additional confirmed the goal specificity of the modified antibody. THIOMAB-TCO was additionally evaluated in vivo after pretargeting and subsequent administration of an 111In-labeled tetrazine. Biodistribution research in breast most cancers tumor-bearing mice confirmed a major exercise accumulation on HER2+ tumors, which was 2.6-fold larger than in HER2 tumors. Moreover, biodistribution research with THIOMAB with out the TCO deal with additionally resulted in a decreased uptake of 111In-DOTA-Tz on HER2+ tumors.

Altogether, these outcomes clearly point out the incidence of the clicking response on the tumor web site, i.e., pretargeting of SK-BR-Three HER2-expressing cells with THIOMAB-TCO and response by the TCO moiety current within the antibody. The mixed benefits of site-selectivity and stability of TCO tagged-antibodies may enable software of biorthogonal chemistry methods for pretargeting imaging with minimal side-reactions and background.

 

Affiliation between serum IgG antibody titers towards Porphyromonas gingivalis and liver enzyme ranges: A cross-sectional examine in Sado Island

Background: Earlier research have reported associations between nonalcoholic fatty liver illness, periodontitis, and weight problems. Serum immunoglobulin G (IgG) antibody titer towards Porphyromonas gingivalis, a serious pathogen of periodontitis, is a longtime indicator of periodontal an infection. Nonetheless, the connection between the antibody titer and liver enzyme ranges has not been clarified but. A examine within the aged was wanted to guage the impact of long-term persistent bacterial an infection on liver operate. The target of this examine was to research the affiliation between liver operate and an infection by P. gingivalis, and the impact of weight problems on the affiliation.
Strategies: A cross-sectional examine was carried out in grownup outpatients visiting Sado Common Hospital, in Niigata Prefecture, Japan, from 2008 to 2010. The ultimate contributors included 192 males and 196 girls (imply age 68.1 years). Multivariable logistic regression analyses have been carried out to evaluate the affiliation between the serum IgG antibody titer and the degrees of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamine transferase (GGT) ranges.
Outcomes: In girls, serum IgG antibody titers towards P. gingivalis was related to elevated ALT, however not with AST or GGT, unbiased of covariates (p = 0.015). No important affiliation was discovered between the antibody titer and the elevated liver enzymes in males. The impact of weight problems on the connection between antibody titer and liver enzyme ranges was not statistically important.
Conclusions: A cross-sectional evaluation of grownup outpatients prompt an affiliation between P. gingivalis an infection and ALT ranges in girls. The impact of weight problems on this affiliation was not statistically important.
 In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry
In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry

Current updates for antibody remedy for acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is a hematologic malignancy arising from precursors of the lymphoid lineage. Standard cytotoxic chemotherapies have resulted in excessive treatment charges of as much as 90% in pediatric ALL, however the outcomes for grownup sufferers stay suboptimal with 5-year survival charges of solely 30%-40%. Present immunotherapies exploit the efficiency of antibodies by a number of totally different mechanisms, together with bare antibodies, antibodies linked to cytotoxic brokers, and T-cell re-directing antibodies.
In contrast with chemotherapy, the appliance of an antibody-drug conjugates (ADC) known as inotuzumab ozogamicin in relapsed or refractory (R/R) CD22+. ALL resulted in a whole remission (CR) fee of 81% and an general median survival of seven.7 months with decreased toxicity. Equally, blinatumomab, the primary FDA-approved bispecific antibody (BsAb), produced a 44% full response fee and an general median survival of seven.7 months in a broadly handled ALL inhabitants.

RELM beta Antibody

DF13943 100ul
EUR 420

RELM beta Antibody

DF13943-100ul 100ul
EUR 280

RELM beta Antibody

DF13943-200ul 200ul
EUR 350

RELM beta antibody

70R-12403 100 ug
EUR 343
Description: Rabbit polyclonal RELM beta antibody

RELM beta antibody

70R-RR006 50 ug
EUR 312
Description: Affinity purified Rabbit polyclonal RELM beta antibody

RELM beta antibody

70R-RR010 50 ug
EUR 312
Description: Affinity purified Rabbit polyclonal RELM beta antibody

RELM beta antibody

70R-RR027 100 ug
EUR 280
Description: Affinity purified Rabbit polyclonal RELM beta antibody

Mouse RELM beta Recombinant Protein Lyophilized

IMSRELMBRLY5UG each
EUR 341
Description: Mouse RELM beta Recombinant Protein Lyophilized

RELM beta protein

30R-AR015 25 ug
EUR 312
Description: Purified recombinant Human RELM beta protein

RELM beta protein

30R-AR018 25 ug
EUR 312
Description: Purified recombinant Human RELM beta protein

RELM beta protein

30R-2671 25 ug
EUR 265
Description: Purified recombinant Human RELM beta protein

RELM beta protein

30R-2672 25 ug
EUR 357
Description: Purified recombinant Human RELM beta protein

RELM beta Protein

20-abx261782
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  • 1 mg
  • 25 ug
  • 5 ug

RELM beta Protein

20-abx261853
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  • 1 mg
  • 25 ug
  • 5 ug

RELM beta Protein

20-abx262084
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  • 1 mg
  • 25 ug
  • 5 ug

RELM beta Protein

abx261782-10mg 10 mg
EUR 325

RELM beta Protein

abx261782-25mg 25 mg
EUR 4237.5

RELM beta Protein

abx261782-5mg 5 mg
EUR 225

RELM beta Protein

abx261853-10mg 10 mg
EUR 4587.5

RELM beta Protein

abx261853-5mg 5 mg
EUR 325

RELM beta Protein

abx262084-10mg 10 mg
EUR 5112.5

RELM beta Protein

abx262084-5mg 5 mg
EUR 325

Relm-Beta (RELmb) Mouse

GWB-D2523A 0.025 mg Ask for price

Recombinant Mouse RELM-beta

7-01513 5µg Ask for price

Recombinant Mouse RELM-beta

7-01514 25µg Ask for price

Recombinant Mouse RELM-beta

7-01515 1mg Ask for price

Recombinant Mouse RELM-beta

cyt-413-1mg 1mg
EUR 2700

Recombinant Mouse RELM-beta

cyt-413-25g 25µg
EUR 145

Recombinant Mouse RELM-beta

cyt-413-5g 5µg
EUR 60

RELM-Beta Mouse Recombinant

rAP-0723 Inquiry Ask for price

RELM beta Recombinant Protein

40-485-0005mg 0.005 mg
EUR 311.1
Description: RELM β (Resistin-like molecule beta/FIZZ2) is an 18 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELM beta, and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver (Rajala, M. et al. J. Clin. Invest. Vol. 111, 225-230 (2003)). Interestingly the molecular structure of RELM beta is highly homologous to that of the adipose-derived cytokine Resistin and RELM beta. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELM beta is an 18.0 kDa, consisting of two 83 amino acid residue chains.

RELM beta Recombinant Protein

40-485-0025mg 0.025 mg
EUR 437.1
Description: RELM β (Resistin-like molecule beta/FIZZ2) is an 18 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELM beta, and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver (Rajala, M. et al. J. Clin. Invest. Vol. 111, 225-230 (2003)). Interestingly the molecular structure of RELM beta is highly homologous to that of the adipose-derived cytokine Resistin and RELM beta. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELM beta is an 18.0 kDa, consisting of two 83 amino acid residue chains.

RELM beta Recombinant Protein

40-102-0005mg 0.005 mg
EUR 311.1
Description: Human RELM-beta is a 19.0 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELM-beta and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly the molecular structure of RELM-beta is highly homologous to that of the adipose-derived cytokine Resistin and RELM-alpha. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Human RELM-beta is a disulfide-linked homodimer with a total molecular weight of 19.0 kDa, consisting of two 89 amino acid residue chains.

RELM beta Recombinant Protein

40-102-0025mg 0.025 mg
EUR 437.1
Description: Human RELM-beta is a 19.0 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELM-beta and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly the molecular structure of RELM-beta is highly homologous to that of the adipose-derived cytokine Resistin and RELM-alpha. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Human RELM-beta is a disulfide-linked homodimer with a total molecular weight of 19.0 kDa, consisting of two 89 amino acid residue chains.

RELM-Beta Mouse Recombinant Protein

PROTQ99P86 Regular: 25ug
EUR 380.4
Description: Mouse RELM-b Recombinant produced in E.Coli is a monomeric, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 8.9kDa. ;The Mouse RETNLB is purified by proprietary chromatographic techniques.

Human RELM beta Recombinant Protein

100-279 25 µg
EUR 196.35
Description: Human RELM beta is a 19.0 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELM beta, and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly the molecular structure of RELM beta is highly homologous to that of the adipose-derived cytokine Resistin and RELMa. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant human RELM beta is a 19.0 kDa homodimer consisting of two identical 89 amino acid chains linked by a single disulfide bond.

Human RELM beta Recombinant Protein

100-279S 5 µg
EUR 92.4
Description: Human RELM beta is a 19.0 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELM beta, and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly the molecular structure of RELM beta is highly homologous to that of the adipose-derived cytokine Resistin and RELMa. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant human RELM beta is a 19.0 kDa homodimer consisting of two identical 89 amino acid chains linked by a single disulfide bond.

Recombinant Human RELM Beta Protein

PROTQ9BQ08-2 25ug
EUR 380.4
Description: Human RELMβ is a 19.0 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMβ and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly the molecular structure of RELMβ is highly homologous to that of the adipose-derived cytokine Resistin and RELMα. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Human RELMβ is a disulfide-linked homodimer with a total molecular weight of 19.0 kDa, consisting of two 89 amino acid residue chains.

Recombinant Murine RELM Beta Protein

PROTQ99P86-1 25ug
EUR 380.4
Description: RELMβ (Resistin-like molecule β/FIZZ2) is an 18 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMβ, and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver (Rajala, M. et al. J. Clin. Invest. Vol. 111, 225-230 (2003)). Interestingly the molecular structure of RELMβ is highly homologous to that of the adipose-derived cytokine Resistin and RELMβ. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELMβ is an 18.0 kDa, consisting of two 83 amino acid residue chains.

Rabbit Anti-Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) antiserum #1

RELMB21-S 100 ul
EUR 548.4

RELM-beta Antibody

5654-100 each
EUR 379.2

RELM-beta Antibody

5654-30T each
EUR 175.2

RELM beta (RETNLB) rabbit polyclonal antibody, Biotin

PP1225B1 25 µg Ask for price

RELM beta (RETNLB) rabbit polyclonal antibody, Biotin

PP1225B2 50 µg Ask for price

FIZZ-2 / RELM-beta (25-45) (Mouse) - Antibody

H-028-44 50 μl
EUR 604.8

FIZZ-2 / RELM-beta (25-45) (Mouse)

028-44 100 μg
EUR 214.92

Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) control/blocking peptide #1

RELMB21-P 100 ug
EUR 196.8

Human RELM beta Recombinant Protein Lyophilized

IHURELMBRLY5UG each
EUR 341
Description: Human RELM beta Recombinant Protein Lyophilized

Rabbit Anti-Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) IgG#1, aff. pure

RELMB21-A 100 ug
EUR 578.4

Rabbit Anti-Human Resistin-Like protein beta (RELM-beta/FIZZ2) antiserum #2

RELMB22-S 100 ul
EUR 548.4

rHu RELM-beta

AK9085-0005 5µg Ask for price

rHu RELM-beta

AK9085-0025 25µg Ask for price

rHu RELM-beta

AK9085-0100 100µg Ask for price

rHu RELM-beta

AK9085-1000 1mg Ask for price

RELM beta (RETNLB) rabbit polyclonal antibody, Aff - Purified

PP1225P1 50 µg Ask for price

RELM beta (RETNLB) rabbit polyclonal antibody, Aff - Purified

PP1225P2 100 µg Ask for price

Recombinant, purified, Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) Protein for WB

RELMB26-C 100 ul
EUR 343.2

Recombinant, purified, Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) Protein (carrier free)

RELMB26-R-25 25 ug
EUR 927.6

Recombinant, purified, Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) Protein (carrier free)

RELMB26-R-5 5 ug
EUR 388.8

Polyclonal RELM-beta Antibody

APR00311G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RELM-beta . This antibody is tested and proven to work in the following applications:

Relm-Alpha (RELMa) Mouse

GWB-3F514C 0.025 mg Ask for price

Relm-Beta (RELmb) Human

GWB-24E47E 0.025 mg Ask for price

RELM beta (RETNLB) (Internal) goat polyclonal antibody, Aff - Purified

AP22581PU-N 50 µg Ask for price

FIZZ-2 / RELM-beta (25-45) (Mouse) - Purified IgG Antibody

G-028-44 200 μg
EUR 604.8

Rabbit Anti-Human Resistin-Like protein beta (RELM-beta/FIZZ2) IgG#2, aff. pure

RELMB22-A 100 ug
EUR 578.4

Human Resistin-Like Molecule beta, RELM-beta GENLISA ELISA

KBH6079 1 x 96 wells
EUR 286

ELISA kit for Human Resistin-like Molecule Beta (RELM-Beta)

KTE60803-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Resistin-like Molecule Beta (RELM-Beta) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Anti-Mouse RELM alpha Antibody

103-M460 100 µg
EUR 399
Description: RELMα, also known as ‘found in inflammatory zone 1’ (FIZZ1) belongs to the RELM/FIZZ family of cysteine rich secretory proteins. RELMα is most abundantly expressed in white adipose tissue but not in pre-adipocytes or 3T3L1 adipocytes. RELMα expression is also detected in mammary tissue, heart, lung, and tongue.

Anti-Mouse RELM alpha Antibody

103-P80 100 µg
EUR 245.7
Description: RELMα, also known as ‘found in inflammatory zone 1’ (FIZZ1) belongs to the RELM/FIZZ family of cysteine rich secretory proteins. RELMα is most abundantly expressed in white adipose tissue but not in pre-adipocytes or 3T3L1 adipocytes. RELMα expression is also detected in mammary tissue, heart, lung, and tongue.

RELM-beta, human recombinant

4654-100 each
EUR 836.4

RELM-beta, human recombinant

4654-1000 each
EUR 3909.6

RELM-beta, human recombinant

4654-25 each
EUR 294

Recombinant Human RELM-beta

7-01510 5µg Ask for price

Recombinant Human RELM-beta

7-01511 25µg Ask for price

Recombinant Human RELM-beta

7-01512 1mg Ask for price

Recombinant Human RELM-beta

cyt-780-1mg 1mg
EUR 2700

Recombinant Human RELM-beta

cyt-780-25g 25µg
EUR 145

Recombinant Human RELM-beta

cyt-780-5g 5µg
EUR 60

RELM-Beta Human Recombinant

rAP-0731 Inquiry Ask for price

RELM-beta, murine recombinant

4655-100 each
EUR 1123.2

RELM-beta, murine recombinant

4655-1000 each
EUR 5318.4

RELM-beta, murine recombinant

4655-25 each
EUR 392.4

Mouse RELM-alpha (Recombinant)

22060739-1 5 µg
EUR 146.42

Recombinant Mouse RELM-alpha

7-01504 5µg Ask for price

Recombinant Mouse RELM-alpha

7-01505 25µg Ask for price

Recombinant Mouse RELM-alpha

7-01506 1mg Ask for price

Recombinant Mouse RELM-Gamma

7-01516 5µg Ask for price

Recombinant Mouse RELM-Gamma

7-01517 25µg Ask for price

Recombinant Mouse RELM-Gamma

7-01518 1mg Ask for price

Recombinant Mouse RELM-Gamma

cyt-1035-1mg 1mg
EUR 2700

Recombinant Mouse RELM-Gamma

cyt-1035-25g 25µg
EUR 145

Recombinant Mouse RELM-Gamma

cyt-1035-5g 5µg
EUR 60

Recombinant Mouse RELM-alpha

cyt-309-1mg 1mg
EUR 2700

Recombinant Mouse RELM-alpha

cyt-309-25g 25µg
EUR 145

Recombinant Mouse RELM-alpha

cyt-309-5g 5µg
EUR 60

Goat Anti-RELM beta Antibody

TA311547 100 µg Ask for price

RELM-alpha Mouse Recombinant

rAP-0722 Inquiry Ask for price

RELM-Gamma Mouse Recombinant

rAP-0726 Inquiry Ask for price

FIZZ-2 / RELM-beta (25-45) (Mouse) - FAM Labeled Purified IgG

FG-G-028-44A 100 μl
EUR 672.84

FIZZ-2 / RELM-beta (25-45) (Mouse) - FITC Labeled Purified IgG

FG-G-028-44B 100 μl
EUR 672.84

Anti- Resistin Like Molecule Alpha(RELM alpha) Mouse Antibody

GWB-96F7E8 0.1 mg Ask for price

Rat Monoclonal anti-mouse RELM alpha

mAP-0313 100ug
EUR 250

Polyclonal FIZZ1 / RELM-Beta Antibody (Internal)

APG01062G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human FIZZ1 / RELM-Beta (Internal). This antibody is tested and proven to work in the following applications:

RELM-Beta Human Recombinant Protein

PROTQ9BQ08-1 Regular: 25ug
EUR 380.4
Description: RELM-b Human Recombinant produced in E.Coli is a disulfide-linked homodimer, non-glycosylated, polypeptide chain containing 2 x 89 amino acids and having a total molecular mass of 19kDa. ;RELM-b is purified by proprietary chromatographic techniques.

FIZZ-2 / RELM-beta (25-45) (Mouse) - Biotin Labeled Purified IgG

B-G-028-44 100 μl
EUR 672.84

OPSD00086-5UG - Recombinant RELM-beta

OPSD00086-5UG 5ug
EUR 108

OPSD00153-5UG - Recombinant RELM-beta

OPSD00153-5UG 5ug
EUR 108

Mouse RELM gamma Recombinant Protein

M10-053 25 µg
EUR 196.35
Description: RELMα belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The other three known members of this family; Resistin, RELMα, and RELMβ, are 85-94 amino acid secreted proteins sharing a conserved C-terminal domain characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELMγ is most closely related to RELMα, but is distinctly secreted to bone marrow, spleen, lung, and in peripheral blood granulocytes. The physiological role of RELMγ may include the promotion or regulation of promyelocytic differentiation, although the specific molecular targets of RELMγ have not been identified. Recombinant murine RELMγ is a 9.2 kDa monomeric protein containing 88 amino acid residues.

Mouse RELM gamma Recombinant Protein

M10-053S 5 µg
EUR 92.4
Description: RELMα belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The other three known members of this family; Resistin, RELMα, and RELMβ, are 85-94 amino acid secreted proteins sharing a conserved C-terminal domain characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELMγ is most closely related to RELMα, but is distinctly secreted to bone marrow, spleen, lung, and in peripheral blood granulocytes. The physiological role of RELMγ may include the promotion or regulation of promyelocytic differentiation, although the specific molecular targets of RELMγ have not been identified. Recombinant murine RELMγ is a 9.2 kDa monomeric protein containing 88 amino acid residues.

Mouse RELM alpha Recombinant Protein

M10-081 25 µg
EUR 196.35
Description: RELMα belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The three known members of this family; Resistin, RELMα and RELMβ are 85-94 amino acid secreted proteins sharing a conserved C-terminal domain characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELMα and Resistin are secreted exclusively by adipocytes while RELMβ is expressed in the epithelium of the colon and small bowel. The physiological role and molecular targets of RELMα re still unknown. Recombinant murine RELMα is a 10.0 kDa monomeric protein containing 88 amino acid residues.

Mouse RELM alpha Recombinant Protein

M10-081S 5 µg
EUR 92.4
Description: RELMα belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The three known members of this family; Resistin, RELMα and RELMβ are 85-94 amino acid secreted proteins sharing a conserved C-terminal domain characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELMα and Resistin are secreted exclusively by adipocytes while RELMβ is expressed in the epithelium of the colon and small bowel. The physiological role and molecular targets of RELMα re still unknown. Recombinant murine RELMα is a 10.0 kDa monomeric protein containing 88 amino acid residues.

Human Resistin-Like protein beta (RELM-beta/FIZZ2) control/blocking peptide #2

RELMB22-P 100 ug
EUR 196.8

FIZZ-2 / RELM-beta (25-45) (Mouse) - I-125 Labeled Purified IgG

T-G-028-44 10 μCi
EUR 1145.88

RELM-alpha Mouse Recombinant Protein

PROTQ9EP95 Regular: 25ug
EUR 380.4
Description: Mouse RELM-alpha Recombinant produced in E.Coli is a monomeric, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10 kDa. The Mouse RELM-alpha is purified by proprietary chromatographic techniques.

RELM-Gamma Mouse Recombinant Protein

PROTQ7TM98 Regular: 25ug
EUR 380.4
Description: RELM g Mouse Recombinant produced in E.Coli is a non glycosylated, homodimeric polypeptide chain containing 2 x 89 amino acids and having a total molecular mass of 18.9kDa. The RELM is purified by proprietary chromatographic techniques.

Recombinant Mouse RELM-alpha His Tag

7-01507 5µg Ask for price

Recombinant Mouse RELM-alpha His Tag

7-01508 25µg Ask for price

Recombinant Mouse RELM-alpha His Tag

7-01509 1mg Ask for price

Recombinant Mouse RELM-alpha His Tag

cyt-453-1mg 1mg
EUR 2900

Recombinant Mouse RELM-alpha His Tag

cyt-453-25g 25µg
EUR 145

Recombinant Mouse RELM-alpha His Tag

cyt-453-5g 5µg
EUR 60

Recombinant Mouse RELM-Gamma, His Tag

cyt-455-1mg 1mg
EUR 2700

Recombinant Mouse RELM-Gamma, His Tag

cyt-455-25g 25µg
EUR 145

Recombinant Mouse RELM-Gamma, His Tag

cyt-455-5g 5µg
EUR 60

Recombinant Human RELM-beta, His Tag

cyt-454-1mg 1mg
EUR 2900

Recombinant Human RELM-beta, His Tag

cyt-454-25g 25µg
EUR 145

Recombinant Human RELM-beta, His Tag

cyt-454-5g 5µg
EUR 60

RELM-Beta Human Recombinant, His Tag

rAP-0725 Inquiry Ask for price

FIZZ-1 / RELM-beta (25-50) (Human) - Antibody

H-028-46 50 μl
EUR 604.8

RELM-Alpha Mouse Recombinant, His Tag

rAP-0724 Inquiry Ask for price

Recombinant, purified, Human Resistin-Like protein beta (RELM-beta/FIZZ2) Protein for WB

RELMB22-C 100 ul
EUR 343.2

FIZZ-1 / RELM-beta (25-50) (Human)

028-46 100 μg
EUR 214.92

Mouse RELM alpha Recombinant Protein Lyophilized

IMSRELMARLY5UG each
EUR 341
Description: Mouse RELM alpha Recombinant Protein Lyophilized
As well as, roughly 80% of sufferers getting full remission with proof of minimal residual illness (MRD) achieved a whole MRD response with using blinatumomab. These outcomes spotlight the nice promise of antibody-based remedy for ALL. Learn how to moderately decide the place of antibody medicine within the therapy of ALL stays a serious downside to be solved for ongoing and future researches.
Tara

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