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In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry

Pretargeted imaging has emerged as an efficient multistep technique aiming to enhance imaging distinction and scale back affected person radiation publicity by decoupling of the radioactivity from the focusing on vector. The inverse electron-demand Diels-Alder (IEDDA) response between a trans-cyclooctene (TCO)-conjugated antibody and a labeled tetrazine holds nice promise for pretargeted imaging purposes because of its bioorthogonality, fast kinetics underneath delicate circumstances, and formation of steady merchandise. Herein, we describe using functionalized carbonylacrylic reagents for site-specific incorporation of TCO onto a human epidermal development issue receptor 2 (HER2) antibody (THIOMAB) containing an engineered unpaired cysteine residue, producing homogeneous conjugates. Exact labeling of THIOMAB-TCO with a fluorescent or radiolabeled tetrazine revealed the potential of the TCO-functionalized antibody for imaging the HER2 after pretargeting in a mobile context in a HER2 optimistic breast most cancers cell line.

Management research with MDA-MD-231 cells, which don’t categorical HER2, additional confirmed the goal specificity of the modified antibody. THIOMAB-TCO was additionally evaluated in vivo after pretargeting and subsequent administration of an 111In-labeled tetrazine. Biodistribution research in breast most cancers tumor-bearing mice confirmed a major exercise accumulation on HER2+ tumors, which was 2.6-fold larger than in HER2 tumors. Moreover, biodistribution research with THIOMAB with out the TCO deal with additionally resulted in a decreased uptake of 111In-DOTA-Tz on HER2+ tumors.

Altogether, these outcomes clearly point out the incidence of the clicking response on the tumor web site, i.e., pretargeting of SK-BR-Three HER2-expressing cells with THIOMAB-TCO and response by the TCO moiety current within the antibody. The mixed benefits of site-selectivity and stability of TCO tagged-antibodies may enable software of biorthogonal chemistry methods for pretargeting imaging with minimal side-reactions and background.

 

Affiliation between serum IgG antibody titers towards Porphyromonas gingivalis and liver enzyme ranges: A cross-sectional examine in Sado Island

Background: Earlier research have reported associations between nonalcoholic fatty liver illness, periodontitis, and weight problems. Serum immunoglobulin G (IgG) antibody titer towards Porphyromonas gingivalis, a serious pathogen of periodontitis, is a longtime indicator of periodontal an infection. Nonetheless, the connection between the antibody titer and liver enzyme ranges has not been clarified but. A examine within the aged was wanted to guage the impact of long-term persistent bacterial an infection on liver operate. The target of this examine was to research the affiliation between liver operate and an infection by P. gingivalis, and the impact of weight problems on the affiliation.
Strategies: A cross-sectional examine was carried out in grownup outpatients visiting Sado Common Hospital, in Niigata Prefecture, Japan, from 2008 to 2010. The ultimate contributors included 192 males and 196 girls (imply age 68.1 years). Multivariable logistic regression analyses have been carried out to evaluate the affiliation between the serum IgG antibody titer and the degrees of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamine transferase (GGT) ranges.
Outcomes: In girls, serum IgG antibody titers towards P. gingivalis was related to elevated ALT, however not with AST or GGT, unbiased of covariates (p = 0.015). No important affiliation was discovered between the antibody titer and the elevated liver enzymes in males. The impact of weight problems on the connection between antibody titer and liver enzyme ranges was not statistically important.
Conclusions: A cross-sectional evaluation of grownup outpatients prompt an affiliation between P. gingivalis an infection and ALT ranges in girls. The impact of weight problems on this affiliation was not statistically important.
 In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry
In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry

Current updates for antibody remedy for acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is a hematologic malignancy arising from precursors of the lymphoid lineage. Standard cytotoxic chemotherapies have resulted in excessive treatment charges of as much as 90% in pediatric ALL, however the outcomes for grownup sufferers stay suboptimal with 5-year survival charges of solely 30%-40%. Present immunotherapies exploit the efficiency of antibodies by a number of totally different mechanisms, together with bare antibodies, antibodies linked to cytotoxic brokers, and T-cell re-directing antibodies.
In contrast with chemotherapy, the appliance of an antibody-drug conjugates (ADC) known as inotuzumab ozogamicin in relapsed or refractory (R/R) CD22+. ALL resulted in a whole remission (CR) fee of 81% and an general median survival of seven.7 months with decreased toxicity. Equally, blinatumomab, the primary FDA-approved bispecific antibody (BsAb), produced a 44% full response fee and an general median survival of seven.7 months in a broadly handled ALL inhabitants.

RELM beta Antibody

DF13943-100ul 100ul
EUR 280

RELM beta Antibody

DF13943-200ul 200ul
EUR 350

RELM beta Antibody

DF13943 100ul
EUR 280
Description: Human

Mouse RELM beta Recombinant Protein Lyophilized

IMSRELMBRLY5UG each
EUR 341
Description: Mouse RELM beta Recombinant Protein Lyophilized

RELM beta Protein

20-abx261782
  • EUR 4936.80
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

RELM beta Protein

20-abx261853
  • EUR 5337.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

RELM beta Protein

20-abx262084
  • EUR 5955.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

RELM beta protein

30R-2671 25 ug
EUR 390
Description: Purified recombinant Human RELM beta protein

RELM beta protein

30R-2672 25 ug
EUR 459.6
Description: Purified recombinant Human RELM beta protein

RELM beta protein

30R-AR015 25 ug
EUR 327.6
Description: Purified recombinant Human RELM beta protein

RELM beta protein

30R-AR018 25 ug
EUR 327.6
Description: Purified recombinant Human RELM beta protein

Recombinant Mouse RELM-beta

7-01513 5µg Ask for price

Recombinant Mouse RELM-beta

7-01514 25µg Ask for price

Recombinant Mouse RELM-beta

7-01515 1mg Ask for price

RELM beta Recombinant Protein

40-102-0005mg 0.005 mg
EUR 311.1
Description: Human RELM-beta is a 19.0 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELM-beta and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly the molecular structure of RELM-beta is highly homologous to that of the adipose-derived cytokine Resistin and RELM-alpha. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Human RELM-beta is a disulfide-linked homodimer with a total molecular weight of 19.0 kDa, consisting of two 89 amino acid residue chains.

RELM beta Recombinant Protein

40-102-0025mg 0.025 mg
EUR 437.1
Description: Human RELM-beta is a 19.0 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELM-beta and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly the molecular structure of RELM-beta is highly homologous to that of the adipose-derived cytokine Resistin and RELM-alpha. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Human RELM-beta is a disulfide-linked homodimer with a total molecular weight of 19.0 kDa, consisting of two 89 amino acid residue chains.

RELM beta Recombinant Protein

40-485-0005mg 0.005 mg
EUR 311.1
Description: RELM β (Resistin-like molecule beta/FIZZ2) is an 18 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELM beta, and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver (Rajala, M. et al. J. Clin. Invest. Vol. 111, 225-230 (2003)). Interestingly the molecular structure of RELM beta is highly homologous to that of the adipose-derived cytokine Resistin and RELM beta. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELM beta is an 18.0 kDa, consisting of two 83 amino acid residue chains.

RELM beta Recombinant Protein

40-485-0025mg 0.025 mg
EUR 437.1
Description: RELM β (Resistin-like molecule beta/FIZZ2) is an 18 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELM beta, and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver (Rajala, M. et al. J. Clin. Invest. Vol. 111, 225-230 (2003)). Interestingly the molecular structure of RELM beta is highly homologous to that of the adipose-derived cytokine Resistin and RELM beta. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELM beta is an 18.0 kDa, consisting of two 83 amino acid residue chains.

RELM-Beta Mouse Recombinant Protein

PROTQ99P86 Regular: 25ug
EUR 380.4
Description: Mouse RELM-b Recombinant produced in E.Coli is a monomeric, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 8.9kDa. ;The Mouse RETNLB is purified by proprietary chromatographic techniques.

Recombinant Human RELM Beta Protein

PROTQ9BQ08-2 25ug
EUR 380.4
Description: Human RELMβ is a 19.0 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMβ and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly the molecular structure of RELMβ is highly homologous to that of the adipose-derived cytokine Resistin and RELMα. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Human RELMβ is a disulfide-linked homodimer with a total molecular weight of 19.0 kDa, consisting of two 89 amino acid residue chains.

Recombinant Murine RELM Beta Protein

PROTQ99P86-1 25ug
EUR 380.4
Description: RELMβ (Resistin-like molecule β/FIZZ2) is an 18 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMβ, and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver (Rajala, M. et al. J. Clin. Invest. Vol. 111, 225-230 (2003)). Interestingly the molecular structure of RELMβ is highly homologous to that of the adipose-derived cytokine Resistin and RELMβ. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELMβ is an 18.0 kDa, consisting of two 83 amino acid residue chains.

RELM-beta Antibody

5654-100 each
EUR 379.2

RELM-beta Antibody

5654-30T each
EUR 175.2

Rabbit Anti-Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) antiserum #1

RELMB21-S 100 ul
EUR 548.4

Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) control/blocking peptide #1

RELMB21-P 100 ug
EUR 196.8

Human RELM beta Recombinant Protein Lyophilized

IHURELMBRLY5UG each
EUR 341
Description: Human RELM beta Recombinant Protein Lyophilized

rHu RELM-beta

AK9085-0005 5µg Ask for price

rHu RELM-beta

AK9085-0025 25µg Ask for price

rHu RELM-beta

AK9085-0100 100µg Ask for price

rHu RELM-beta

AK9085-1000 1mg Ask for price

Rabbit Anti-Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) IgG#1, aff. pure

RELMB21-A 100 ug
EUR 578.4

Recombinant, purified, Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) Protein for WB

RELMB26-C 100 ul
EUR 343.2

Rabbit Anti-Human Resistin-Like protein beta (RELM-beta/FIZZ2) antiserum #2

RELMB22-S 100 ul
EUR 548.4

Polyclonal RELM-beta Antibody

APR00311G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RELM-beta . This antibody is tested and proven to work in the following applications:

Recombinant, purified, Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) Protein (carrier free)

RELMB26-R-25 25 ug
EUR 927.6

Recombinant, purified, Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) Protein (carrier free)

RELMB26-R-5 5 ug
EUR 388.8

Rabbit Anti-Human Resistin-Like protein beta (RELM-beta/FIZZ2) IgG#2, aff. pure

RELMB22-A 100 ug
EUR 578.4

Recombinant Human RELM-beta

7-01510 5µg Ask for price

Recombinant Human RELM-beta

7-01511 25µg Ask for price

Recombinant Human RELM-beta

7-01512 1mg Ask for price

RELM-beta, human recombinant

4654-100 each
EUR 836.4

RELM-beta, human recombinant

4654-1000 each
EUR 3909.6

RELM-beta, human recombinant

4654-25 each
EUR 294

RELM-beta, murine recombinant

4655-100 each
EUR 1123.2

RELM-beta, murine recombinant

4655-1000 each
EUR 5318.4

RELM-beta, murine recombinant

4655-25 each
EUR 392.4

ELISA kit for Human Resistin-like Molecule Beta (RELM-Beta)

KTE60803-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human Resistin-like Molecule Beta (RELM-Beta) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Resistin-like Molecule Beta (RELM-Beta)

KTE60803-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Resistin-like Molecule Beta (RELM-Beta) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Resistin-like Molecule Beta (RELM-Beta)

KTE60803-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human Resistin-like Molecule Beta (RELM-Beta) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Recombinant Mouse RELM-alpha

7-01504 5µg Ask for price

Recombinant Mouse RELM-alpha

7-01505 25µg Ask for price

Recombinant Mouse RELM-alpha

7-01506 1mg Ask for price

Recombinant Mouse RELM-Gamma

7-01516 5µg Ask for price

Recombinant Mouse RELM-Gamma

7-01517 25µg Ask for price

Recombinant Mouse RELM-Gamma

7-01518 1mg Ask for price

Mouse RELM-alpha (Recombinant)

22060739-1 5 µg
EUR 146.42

RELM-Beta Human Recombinant Protein

PROTQ9BQ08-1 Regular: 25ug
EUR 380.4
Description: RELM-b Human Recombinant produced in E.Coli is a disulfide-linked homodimer, non-glycosylated, polypeptide chain containing 2 x 89 amino acids and having a total molecular mass of 19kDa. ;RELM-b is purified by proprietary chromatographic techniques.

Polyclonal FIZZ1 / RELM-Beta Antibody (Internal)

APG01062G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human FIZZ1 / RELM-Beta (Internal). This antibody is tested and proven to work in the following applications:

RELM-Gamma Mouse Recombinant Protein

PROTQ7TM98 Regular: 25ug
EUR 380.4
Description: RELM g Mouse Recombinant produced in E.Coli is a non glycosylated, homodimeric polypeptide chain containing 2 x 89 amino acids and having a total molecular mass of 18.9kDa. The RELM is purified by proprietary chromatographic techniques.

RELM-alpha Mouse Recombinant Protein

PROTQ9EP95 Regular: 25ug
EUR 380.4
Description: Mouse RELM-alpha Recombinant produced in E.Coli is a monomeric, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10 kDa. The Mouse RELM-alpha is purified by proprietary chromatographic techniques.

Human Resistin-Like protein beta (RELM-beta/FIZZ2) control/blocking peptide #2

RELMB22-P 100 ug
EUR 196.8

Recombinant Mouse RELM-alpha His Tag

7-01507 5µg Ask for price

Recombinant Mouse RELM-alpha His Tag

7-01508 25µg Ask for price

Recombinant Mouse RELM-alpha His Tag

7-01509 1mg Ask for price

Recombinant, purified, Human Resistin-Like protein beta (RELM-beta/FIZZ2) Protein for WB

RELMB22-C 100 ul
EUR 343.2

Mouse RELM alpha Recombinant Protein Lyophilized

IMSRELMARLY5UG each
EUR 341
Description: Mouse RELM alpha Recombinant Protein Lyophilized

Mouse RELM gamma Recombinant Protein Lyophilized

IMSRELMGRLY5UG each
EUR 341
Description: Mouse RELM gamma Recombinant Protein Lyophilized

RELM b

cyt-780 5µg
EUR 60
Description: Recombinant Human RELM-beta

Recombinant, purified, Human Resistin-Like protein beta (RELM-beta/FIZZ2) Protein (carrier free)

RELMB25-R-25 25 ug
EUR 927.6

RELM alpha

E8ER1915-81 100ul
EUR 275
Description: Available in various conjugation types.

RELM alpha antibody

70R-RR003 100 ug
EUR 360
Description: Affinity purified Rabbit polyclonal RELM alpha antibody

RELM alpha antibody

70R-RR005 50 ug
EUR 327.6
Description: Affinity purified Rabbit polyclonal RELM alpha antibody

RELM alpha antibody

70R-12390 100 ug
EUR 483.6
Description: Rabbit polyclonal RELM alpha antibody

RELM-Beta Human Recombinant Protein, His Tag

PROTQ9BQ08 Regular: 25ug
EUR 380.4
Description: RELM-beta Human Recombinant is a His-Tagged Fusion Protein which is 11 kDa protein containing 90 amino acid residues of the RELM-beta human and 12 additional amino acid residues - HisTag (underlined).

RELM-alpha Antibody

5631-100 each
EUR 379.2

RELM-alpha Antibody

5631-30T each
EUR 175.2

RELM-Alpha Mouse Recombinant Protein, His Tag

PROTQ9EP95-1 Regular: 25ug
EUR 380.4
Description: RELM-alpha Mouse Recombinant is manufactured with a signal sequence of phage fd (20aa) and C-terminal fusion of flagTag (10aa). The RELM-alpha Flag-Tagged Fusion Protein is a 13.3 kDa protein containing 91 amino acid residues with 30 additional amino acid residues - signal sequence of phage fd, flagTag (underlined).

RELM b His

cyt-454 5µg
EUR 60
Description: Recombinant Human RELM-beta, His Tag

Recombinant Mouse RELM g Protein, Untagged, E.coli-1mg

QP13295-1mg 1mg
EUR 3308.4

Recombinant Mouse RELM g Protein, Untagged, E.coli-5ug

QP13295-5ug 5ug
EUR 186

Recombinant Mouse RELM g Protein, Untagged, E.coli-25ug

QP13295-25ug 25ug
EUR 241.2

Recombinant Human RELM-beta Protein, Untagged, E.coli-1mg

QP5281-1mg 1mg
EUR 3427.2

Recombinant Human RELM-beta Protein, Untagged, E.coli-5ug

QP5281-5ug 5ug
EUR 163.2

Recombinant Human RELM-beta Protein, Untagged, E.coli-25ug

QP5281-25ug 25ug
EUR 284.4

Recombinant Human RELM-beta Protein, Untagged, E.coli-100ug

QP5281-100ug 100ug
EUR 588

Recombinant Human RELM-beta Protein, Untagged, E.coli-500ug

QP5281-500ug 500ug
EUR 2133.6

RELM alpha Protein

20-abx260719
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

RELM gamma Protein

20-abx261846
  • EUR 5337.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

RELM alpha Protein

20-abx262083
  • EUR 5955.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

RELM alpha protein

30R-2664 25 ug
EUR 390
Description: Purified recombinant Mouse RELM alpha protein

RELM alpha protein

30R-AR017 5 ug
EUR 152.4
Description: Purified recombinant murine RELM alpha protein

RELM gamma protein

30R-AR031 25 ug
EUR 327.6
Description: Purified recombinant Human RELM gamma protein

RELM?, murine recombinant

7196-10 each
EUR 248.4

RELM?, murine recombinant

7196-50 each
EUR 810

Polyclonal RELM-alpha Antibody

AMM07565G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RELM-alpha . This antibody is tested and proven to work in the following applications:

Human RELM-β ELISA kit

E22-HC012b.48 48T
EUR 295

Human RELM-β ELISA kit

E22-HC012b.96 96T
EUR 395

Mouse Anti-TrCP,Beta

Ab5151 100ug
EUR 934.8

RELM alpha Recombinant Protein

40-484-0005mg 0.005 mg
EUR 311.1
Description: RELM-alpha belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The three known members of this family; Resistin, RELM-alpha and RELM-beta are 85-94 amino acid secreted proteins sharing a conserved C-terminal domain characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELM-alpha and Resistin are secreted exclusively by adipocytes while RELM-beta is expressed in the epithelium of the colon and small bowel. The physiological role and molecular targets of RELM-alpha re still unknown. Recombinant murine RELM-alpha is a 10.0 kDa monomeric protein containing 88 amino acid residues.

RELM alpha Recombinant Protein

40-484-0025mg 0.025 mg
EUR 437.1
Description: RELM-alpha belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The three known members of this family; Resistin, RELM-alpha and RELM-beta are 85-94 amino acid secreted proteins sharing a conserved C-terminal domain characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELM-alpha and Resistin are secreted exclusively by adipocytes while RELM-beta is expressed in the epithelium of the colon and small bowel. The physiological role and molecular targets of RELM-alpha re still unknown. Recombinant murine RELM-alpha is a 10.0 kDa monomeric protein containing 88 amino acid residues.

RELM gamma Recombinant Protein

40-486-0005mg 0.005 mg
EUR 311.1
Description: RELMα belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The other three known members of this family; Resistin, RELMα, and RELMβ, are 85-94 amino acid secreted proteins sharing a conserved C-terminal domain characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELMγ is most closely related to RELMα, but is distinctly secreted to bone marrow, spleen, lung, and in peripheral blood granulocytes. The physiological role of RELMγ may include the promotion or regulation of promyelocytic differentiation, although the specific molecular targets of RELMγ have not been identified. Recombinant murine RELMγ is a 9.2 kDa monomeric protein containing 88 amino acid residues.

RELM gamma Recombinant Protein

40-486-0025mg 0.025 mg
EUR 437.1
Description: RELMα belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The other three known members of this family; Resistin, RELMα, and RELMβ, are 85-94 amino acid secreted proteins sharing a conserved C-terminal domain characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELMγ is most closely related to RELMα, but is distinctly secreted to bone marrow, spleen, lung, and in peripheral blood granulocytes. The physiological role of RELMγ may include the promotion or regulation of promyelocytic differentiation, although the specific molecular targets of RELMγ have not been identified. Recombinant murine RELMγ is a 9.2 kDa monomeric protein containing 88 amino acid residues.

RELM-alpha, murine recombinant

4631-100 each
EUR 836.4

RELM-alpha, murine recombinant

4631-1000 each
EUR 3909.6

RELM-alpha, murine recombinant

4631-25 each
EUR 294

Mouse anti-CG beta Antibody

DL99549A-100ul 100 ul
EUR 299
Description: CGB3; Choriogonadotropin subunit beta; CG-beta; Chorionic gonadotrophin chain beta

Mouse anti-CG beta Antibody

DL99549A-50ul 50 ul
EUR 210
Description: CGB3; Choriogonadotropin subunit beta; CG-beta; Chorionic gonadotrophin chain beta

Mouse anti-FSH beta Antibody

DL99597A-100ul 100 ul
EUR 299
Description: Follitropin subunit beta; Follicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chain

Mouse anti-FSH beta Antibody

DL99597A-50ul 50 ul
EUR 210
Description: Follitropin subunit beta; Follicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chain

Mouse anti-FSH beta Antibody

DL99688A-100ul 100 ul
EUR 299
Description: Follitropin subunit beta; Follicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chain

Mouse anti-FSH beta Antibody

DL99688A-50ul 50 ul
EUR 210
Description: Follitropin subunit beta; Follicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chain

Mouse anti-HIF1 beta Antibody

DL95510A-100ul 100 ul
EUR 370
Description: BHLHE2; Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta

Mouse anti-HIF1 beta Antibody

DL95510A-50ul 50 ul
EUR 259
Description: BHLHE2; Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta

Mouse anti-HIF1 beta Antibody

YLD8477-100ul 100 ul
EUR 320
Description: Mouse monoclonal antibody to HIF1 beta

Mouse anti-HIF1 beta Antibody

YLD8477-50ul 50 ul
EUR 200
Description: Mouse monoclonal antibody to HIF1 beta

Mouse anti-HSP90 beta Antibody

DL95532A-100ul 100 ul
EUR 325
Description: HSP90B; HSPC2; HSPCB; Heat shock protein HSP 90-beta; HSP 90; Heat shock 84 kDa; HSP 84; HSP84

Mouse anti-HSP90 beta Antibody

DL95532A-50ul 50 ul
EUR 227.5
Description: HSP90B; HSPC2; HSPCB; Heat shock protein HSP 90-beta; HSP 90; Heat shock 84 kDa; HSP 84; HSP84

Mouse anti-HSP90 beta Antibody

YLD8505-100ul 100 ul
EUR 320
Description: Mouse monoclonal antibody to HSP90 beta

Mouse anti-HSP90 beta Antibody

YLD8505-50ul 50 ul
EUR 200
Description: Mouse monoclonal antibody to HSP90 beta

Mouse Recombinant purified Resistin-Like protein alpha (RELM-alpha/FIZZ1)

RELMA15-R-25 25 ug
EUR 927.6

Mouse Recombinant purified Resistin-Like protein alpha (RELM-alpha/FIZZ1)

RELMA15-R-5 5 ug
EUR 388.8

Mouse anti-Thyrotropin beta Antibody

DL99612A-100ul 100 ul
EUR 299
Description: Thyrotropin subunit beta; Thyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chain; Thyrotropin alfa

Mouse anti-Thyrotropin beta Antibody

DL99612A-50ul 50 ul
EUR 210
Description: Thyrotropin subunit beta; Thyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chain; Thyrotropin alfa

Mouse Resistin-Like protein gamma (RELM-gamma) control/blocking peptide #1

RELMG31-P 100 ug
EUR 196.8

Rabbit Anti-Mouse Resistin-Like protein alpha (RELM-alpha/FIZZ1) antiserum #1

RELMA11-S 100 ul
EUR 548.4

Recombinant Murine RELM Gamma Protein

PROTQ7TM98-1 25ug
EUR 380.4
Description: RELMα belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The other three known members of this family; Resistin, RELMα, and RELMβ, are 85-94 amino acid secreted proteins sharing a conserved C-terminal domain characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELMγ is most closely related to RELMα, but is distinctly secreted to bone marrow, spleen, lung, and in peripheral blood granulocytes. The physiological role of RELMγ may include the promotion or regulation of promyelocytic differentiation, although the specific molecular targets of RELMγ have not been identified. Recombinant murine RELMγ is a 9.2 kDa monomeric protein containing 88 amino acid residues.

Recombinant Murine RELM Alpha Protein

PROTQ9EP95-2 25ug
EUR 380.4
Description: RELMα belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The three known members of this family; Resistin, RELMα and RELMβ are 85-94 amino acid secreted proteins sharing a conserved C-terminal domain characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELMα and Resistin are secreted exclusively by adipocytes while RELMβ is expressed in the epithelium of the colon and small bowel. The physiological role and molecular targets of RELMα re still unknown. Recombinant murine RELMα is a 10.0 kDa monomeric protein containing 88 amino acid residues.

Rat monoclonal Anti-Mouse Resistin-Like protein alpha (RELM-alpha/FIZZ1) ascites

RELMA13-M 100 ul
EUR 578.4

Anti-defensin, beta 1 (mouse) antibody

STJ72642 100 µg
EUR 312

Anti-Defensin, beta 19 (mouse) antibody

STJ72662 100 µg
EUR 312

Rabbit Anti-Mouse Resistin-Like protein gamma (RELM-gamma) IgG#1 aff Pure

RELMG31-A 100 ug
EUR 578.4

Mouse Anti-TrCP,Beta - AP Conjugated

Ab5251 100ul
EUR 1437.6

Recombinant Mouse Resistin-Like protein alpha (RELM-alpha/FIZZ1) Protein for WB

RELMA11-C 100 ul
EUR 343.2
As well as, roughly 80% of sufferers getting full remission with proof of minimal residual illness (MRD) achieved a whole MRD response with using blinatumomab. These outcomes spotlight the nice promise of antibody-based remedy for ALL. Learn how to moderately decide the place of antibody medicine within the therapy of ALL stays a serious downside to be solved for ongoing and future researches.

Tara

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