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Pilot Trial of Eltrombopag in Patients

Pilot Trial of Eltrombopag in Sufferers Present process Chemotherapy for Malignant Strong T

Eltrombopag is an orally administered, small molecule thrombopoietin receptor (TPO-R) agonist that stimulates platelet manufacturing by a mechanism related, however not similar to endogenous TPO.

Eltrombopag interacts with the transmembrane area of the TPO-R (also referred to as C-MPL) resulting in elevated platelet manufacturing (Erickson-Miller, 2010; Solar et al, 2012).

Eltrombopag is indicated for the remedy of thrombocytopenia in grownup and pediatric sufferers one yr and older with power immune (idiopathic) thrombocytopenia (ITP) who’ve had an inadequate response to corticosteroids, immunoglobulins, or splenectomy.

Eltrombopag has additionally been authorised for the remedy of thrombocytopenia in grownup sufferers with power hepatitis C to permit for the initiation and upkeep of interferon-based remedy and for the remedy of cytopenias in grownup sufferers with extreme aplastic anemia (SAA) who’ve had inadequate responses to immunosuppressive remedy.

That is an open label, single middle pilot trial of eltrombopag in pediatric sufferers receiving most cancers directed remedy for stable tumors.

The function of this examine is to discover the platelet supportive care results and security of eltrombopag in pediatric sufferers (ages one to 18 years of age) present process intensive chemotherapy for malignant stable tumors.

The major endpoint can be to find out the security of eltrombopag in pediatric sufferers present process intensive chemotherapy for malignant stable tumors utilizing CTCAE v5.zero standards.

The secondary endpoint can be to find out the efficacy of eltrombopag in pediatric sufferers present process intensive chemotherapy for malignant stable tumors.

These targets can be assessed by evaluating drug-related toxicities, the platelet response in sufferers and the proportion of topics receiving eltrombopag who’re platelet transfusion-free throughout the time interval of chemotherapy.

The examine will enroll 10 topics with histologically confirmed stable tumors, together with however not restricted to rhabdomyosarcoma, Ewing sarcoma, osteosarcoma, non-rhabdomyosarcoma smooth tissue sarcoma, peripheral nerve sheath tumor, desmoplastic small spherical cell tumor, hepatoblastoma, hepatocellular carcinoma, renal cell carcinoma, larger grade neuroblastoma, medulloblastoma, or different uncommon malignant solidtumors.

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Hydrogen Peroxide Assay Kit

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ProtoBlock System

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450ML PBS 10X

NAT1006 450ML
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500G Acrylamide

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1KG Acrylamide

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25G AquaPor LE

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100G AquaPor LE GTAC

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25G AquaPor ES

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25G AquaPor LM

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100G AquaPor LM

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25G AquaPor HR

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100G AquaPor HR

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25G AquaPor 3:1

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100G AquaPor 3:1

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25G Bis (Methylene Bis-Acrylamide)

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25G DATD Ultrapure

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250G Glycine

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1KG Glycine Ultrapure

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250G Tris

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1KG Tris Ultrapure

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100G Tricine

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100G Ion Exchange Resin (mixed bed)

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25G Riboflavin

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25ML TEMED

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25G Ammonium Persulfate

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100G Ammonium Persulfate

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1G Dithiothreitol (DTT)

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5G Dithiothreitol (DTT)

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50ML 2-Mercaptoethanol

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1KG Urea

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1L ProtoBlue Safe

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1L ProtoStain Blue

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25ML Nuclistain

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450ML AcrylaGel 30%

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NAT1118 1L
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450ML Bis-AcrylaGel 2%

NAT1120 450ML
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1L Bis-AcrylaGel 2%

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EUR 111.6

450ML UreaGel 29:1 Concentrate

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1L UreaGel 29:1 Concentrate

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UreaGel 29:1 System 1L Kit

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EUR 171.6

UreaGel 29:1 System 2.2L Kit

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EUR 253.2

450ML SequaGel UreaGel Concentrate

NAT1132 450ML
EUR 126

1L SequaGel UreaGel Concentrate

NAT1134 1L
EUR 160.8

SequaGel Sequencing System 1L Kit

NAT1136 1KIT
EUR 171.6

SequaGel Sequencing System 2.2L Kit

NAT1138 EACH
EUR 253.2

100ML SequaGel Buffer

NAT1140 100ML
EUR 80.4

200ML SequaGel UreaGel Buffer

NAT1142 200ML
EUR 84

450ML SequaGel UreaGel-6

NAT1144 450ML
EUR 115.2

1L SequaGel UreaGel-6

NAT1146 1L
EUR 151.2

450ML SequaGel UreaGel-8

NAT1148 450ML
EUR 115.2

1L SequaGel UreaGel-8

NAT1150 1L
EUR 151.2

450ML SequaGel UreaGel Diluent

NAT1152 450ML
EUR 90

1L SequaGel UreaGel Diluent

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EUR 103.2

90ML SequaGel Complete Buffer

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EUR 79.2

 

The most cancers directed remedy can be a part of commonplace remedy for every affected person and can consist of two to 4 cycles of chemotherapy (or as many as clinically indicated per doctor discretion) to scale back tumor burden, adopted by surgical procedure within the majority of circumstances, and/or radiation in a minority of circumstances, or each in uncommon circumstances at varied instances in the midst of remedy.

After restoration from the surgical procedure and/or radiation, chemotherapy and eltrombopag can be resumed till completion. Every cycle of chemotherapy can be roughly two to 4 weeks (14 to 28 days) in size with chemotherapy administered for one to 5 days per cycle.

The period of chemotherapy varies by routine and underlying malignancy.

Sufferers will provoke eltrombopag on the primary day following the completion of chemotherapy for every cycle (e.g., chemo is run on Days 1-5, eltrombopag to begin on Day 6).

Eltrombopag can be administered each day and the dose can be age dependent (see Desk 5).

Youngsters lower than 6 years of age will obtain a beginning dose of 25 mg by mouth as soon as each day, taken on empty abdomen one hour earlier than or two hours after a meal.

For youngsters larger than or equal to six years of age, the beginning dose can be 75 mg by mouth as soon as each day.

Doses shall be decreased in sufferers of Asian ancestry (e.g., Japanese, Chinese language, Taiwanese, or Korean): for these sufferers larger than or equal to six years of age, the beginning dose can be 50 mg by mouth as soon as each day and for these sufferers lower than 6 years outdated, the beginning dose can be 12.5 mg by mouth as soon as each day.

Eltrombopag can be continued till the platelets are at the least 100,000/µL after the nadir.

Topics can be recruited from the UC Davis ComprehensiveCancerCenter or when they’re admitted to UC Davis Youngsters’s Hospital.

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Diogenes Kit

NAT1000 1KIT
EUR 270

Hydrogen Peroxide Assay Kit

NAT1002 1KIT
EUR 308.4

ProtoBlock System

NAT1004 1KIT
EUR 122.4

450ML PBS 10X

NAT1006 450ML
EUR 96

4L PBS 10X

NAT1008 4L
EUR 238.8

ProtoGlow ECL 200ml Kit

NAT1010 EACH
EUR 354

ProtoGlow ECL 500ml Kit

NAT1012 EACH
EUR 627.6

100G Acrylamide

NAT1014 100G
EUR 120

500G Acrylamide

NAT1016 500G
EUR 261.6

1KG Acrylamide

NAT1018 1KG
EUR 412.8

25G AquaPor LE

NAT1020 25G
EUR 132

100G AquaPor LE GTAC

NAT1022 100G
EUR 250.8

500G AquaPor LE GTAC

NAT1024 500G
EUR 878.4

25G AquaPor ES

NAT1026 25G
EUR 152.4

100G AquaPor ES

NAT1028 100G
EUR 350.4

25G AquaPor LM

NAT1030 25G
EUR 288

100G AquaPor LM

NAT1032 100G
EUR 860.4

25G AquaPor HR

NAT1034 25G
EUR 236.4

100G AquaPor HR

NAT1036 100G
EUR 592.8

25G AquaPor 3:1

NAT1038 25G
EUR 250.8

100G AquaPor 3:1

NAT1040 100G
EUR 570

25G Bis (Methylene Bis-Acrylamide)

NAT1042 25G
EUR 100.8

25G DATD Ultrapure

NAT1044 25G
EUR 168

250G Glycine

NAT1046 250G
EUR 94.8

1KG Glycine Ultrapure

NAT1048 1KG
EUR 128.4

250G Tris

NAT1050 250G
EUR 102

1KG Tris Ultrapure

NAT1052 1KG
EUR 177.6

100G Tricine

NAT1054 100G
EUR 120

100G Ion Exchange Resin (mixed bed)

NAT1056 100G
EUR 96

25G Riboflavin

NAT1058 25G
EUR 96

25ML TEMED

NAT1060 25ML
EUR 99.6

25G Ammonium Persulfate

NAT1062 25G
EUR 96

100G Ammonium Persulfate

NAT1064 100G
EUR 118.8

1G Dithiothreitol (DTT)

NAT1066 1G
EUR 103.2

5G Dithiothreitol (DTT)

NAT1068 5G
EUR 183.6

50ML 2-Mercaptoethanol

NAT1070 50ML
EUR 112.8

100G SDS Ultrapure

NAT1072 100G
EUR 111.6

1KG SDS Ultrapure

NAT1074 1KG
EUR 457.2

250G Urea

NAT1076 250G
EUR 98.4

1KG Urea

NAT1078 1KG
EUR 138

450ML Glycerol Ultrapure

NAT1080 450ML
EUR 132

200ML Tween 20 Ultrapure

NAT1082 200ML
EUR 132

1L Tween 20

NAT1084 1L
EUR 169.2

200ML Formamide

NAT1086 200ML
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500ML Boric Acid

NAT1088 500ML
EUR 103.2

100G EDTA

NAT1090 100G
EUR 94.8

500G EDTA

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EUR 177.6

GelDry Film 11 X 12 cm

NAT1094 PK50
EUR 100.8

25ML Formamide CE

NAT1096 25ML Ask for price

25ML Glass Bond

NAT1098 25ML
EUR 158.4

450ML Glass Free

NAT1100 450ML
EUR 196.8

GelDry Film 22.5 X 22.5 cm

NAT1102 PK50
EUR 130.8

1L DEPC Treated Water

NAT1104 1L
EUR 120

Sterling Rapid Silver Stain Kit

NAT1106 1KIT
EUR 265.2

1L ProtoBlue Safe

NAT1108 1L
EUR 159.6

4L ProtoBlue Safe

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1L ProtoStain Blue

NAT1112 1L
EUR 164.4

25ML Nuclistain

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450ML AcrylaGel 30%

NAT1116 450ML
EUR 128.4

1L AcrylaGel 30%

NAT1118 1L
EUR 177.6

450ML Bis-AcrylaGel 2%

NAT1120 450ML
EUR 98.4

1L Bis-AcrylaGel 2%

NAT1122 1L
EUR 111.6

450ML UreaGel 29:1 Concentrate

NAT1124 450ML
EUR 133.2

1L UreaGel 29:1 Concentrate

NAT1126 1L
EUR 183.6

UreaGel 29:1 System 1L Kit

NAT1128 EACH
EUR 171.6

UreaGel 29:1 System 2.2L Kit

NAT1130 EACH
EUR 253.2

450ML SequaGel UreaGel Concentrate

NAT1132 450ML
EUR 126

1L SequaGel UreaGel Concentrate

NAT1134 1L
EUR 160.8

SequaGel Sequencing System 1L Kit

NAT1136 1KIT
EUR 171.6

SequaGel Sequencing System 2.2L Kit

NAT1138 EACH
EUR 253.2

100ML SequaGel Buffer

NAT1140 100ML
EUR 80.4

200ML SequaGel UreaGel Buffer

NAT1142 200ML
EUR 84

450ML SequaGel UreaGel-6

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EUR 115.2

1L SequaGel UreaGel-6

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EUR 151.2

450ML SequaGel UreaGel-8

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EUR 115.2

1L SequaGel UreaGel-8

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EUR 151.2

450ML SequaGel UreaGel Diluent

NAT1152 450ML
EUR 90

1L SequaGel UreaGel Diluent

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EUR 103.2

90ML SequaGel Complete Buffer

NAT1156 90ML
EUR 79.2

200ML SequaGel UreaGel Complete Buffer

NAT1158 200ML
EUR 85.2

450ML SequaGel XR

NAT1160 450ML
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1L SequaGel XR

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100ML SequaGel XR Concentrate

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450ML SequaGel XR Concentrate

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200ML SequaGel MD Monomer Solution

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SequaGel MD SSCP Kit

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SequaGel MD Heteroduplex Kit

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1.2ML SequaGel MD SSCP Stop Solution

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