Eltrombopag is an orally administered, small molecule thrombopoietin receptor (TPO-R) agonist that stimulates platelet manufacturing by a mechanism related, however not similar to endogenous TPO.

Eltrombopag interacts with the transmembrane area of the TPO-R (also referred to as C-MPL) resulting in elevated platelet manufacturing (Erickson-Miller, 2010; Solar et al, 2012).

Eltrombopag is indicated for the remedy of thrombocytopenia in grownup and pediatric sufferers one yr and older with power immune (idiopathic) thrombocytopenia (ITP) who’ve had an inadequate response to corticosteroids, immunoglobulins, or splenectomy.

Eltrombopag has additionally been authorised for the remedy of thrombocytopenia in grownup sufferers with power hepatitis C to permit for the initiation and upkeep of interferon-based remedy and for the remedy of cytopenias in grownup sufferers with extreme aplastic anemia (SAA) who’ve had inadequate responses to immunosuppressive remedy.

That is an open label, single middle pilot trial of eltrombopag in pediatric sufferers receiving most cancers directed remedy for stable tumors.

The function of this examine is to discover the platelet supportive care results and security of eltrombopag in pediatric sufferers (ages one to 18 years of age) present process intensive chemotherapy for malignant stable tumors.

The major endpoint can be to find out the security of eltrombopag in pediatric sufferers present process intensive chemotherapy for malignant stable tumors utilizing CTCAE v5.zero standards.

The secondary endpoint can be to find out the efficacy of eltrombopag in pediatric sufferers present process intensive chemotherapy for malignant stable tumors.

These targets can be assessed by evaluating drug-related toxicities, the platelet response in sufferers and the proportion of topics receiving eltrombopag who’re platelet transfusion-free throughout the time interval of chemotherapy.

The examine will enroll 10 topics with histologically confirmed stable tumors, together with however not restricted to rhabdomyosarcoma, Ewing sarcoma, osteosarcoma, non-rhabdomyosarcoma smooth tissue sarcoma, peripheral nerve sheath tumor, desmoplastic small spherical cell tumor, hepatoblastoma, hepatocellular carcinoma, renal cell carcinoma, larger grade neuroblastoma, medulloblastoma, or different uncommon malignant solidtumors.

The most cancers directed remedy can be a part of commonplace remedy for every affected person and can consist of two to 4 cycles of chemotherapy (or as many as clinically indicated per doctor discretion) to scale back tumor burden, adopted by surgical procedure within the majority of circumstances, and/or radiation in a minority of circumstances, or each in uncommon circumstances at varied instances in the midst of remedy.

After restoration from the surgical procedure and/or radiation, chemotherapy and eltrombopag can be resumed till completion. Every cycle of chemotherapy can be roughly two to 4 weeks (14 to 28 days) in size with chemotherapy administered for one to 5 days per cycle.

The period of chemotherapy varies by routine and underlying malignancy.

Sufferers will provoke eltrombopag on the primary day following the completion of chemotherapy for every cycle (e.g., chemo is run on Days 1-5, eltrombopag to begin on Day 6).

Eltrombopag can be administered each day and the dose can be age dependent (see Desk 5).

Youngsters lower than 6 years of age will obtain a beginning dose of 25 mg by mouth as soon as each day, taken on empty abdomen one hour earlier than or two hours after a meal.

For youngsters larger than or equal to six years of age, the beginning dose can be 75 mg by mouth as soon as each day.

Doses shall be decreased in sufferers of Asian ancestry (e.g., Japanese, Chinese language, Taiwanese, or Korean): for these sufferers larger than or equal to six years of age, the beginning dose can be 50 mg by mouth as soon as each day and for these sufferers lower than 6 years outdated, the beginning dose can be 12.5 mg by mouth as soon as each day.

Eltrombopag can be continued till the platelets are at the least 100,000/µL after the nadir.

Topics can be recruited from the UC Davis ComprehensiveCancerCenter or when they’re admitted to UC Davis Youngsters’s Hospital.

Alpha-bungarotoxin, CF405s
00002-100ug	Biotium	100uG	EUR 193.2
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF680r
9-00003	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF680r
9-00003	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF640r
9-00004	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF640r
9-00004	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF488a
9-00005	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF488a
9-00005	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF568
9-00006	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF568
9-00006	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF594
9-00007	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF594
9-00007	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF633
9-00009	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF633
9-00009	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin
00010-1	Biotium	1MG	EUR 201.6
Description: Minimum order quantity: 1 unit of 1MG

Fluorescein-Alpha-bungarotoxin
00011	Biotium	500uG	EUR 440.4
Description: Minimum order quantity: 1 unit of 500uG

Tetramethylrhodamine-Alpha-bungarotoxin
00012	Biotium	500uG	EUR 459.6
Description: Minimum order quantity: 1 unit of 500uG

Fluorescein-alpha-bungarotoxin: (10x50ug)
00013	Biotium	10ST	EUR 500.4
Description: Minimum order quantity: 1 unit of 10ST

Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug)
00014	Biotium	10ST	EUR 559.2
Description: Minimum order quantity: 1 unit of 10ST

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug)
00015	Biotium	500uG	EUR 559.2
Description: Minimum order quantity: 1 unit of 500uG

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug)
00016	Biotium	10ST	EUR 627.6
Description: Minimum order quantity: 1 unit of 10ST

Biotin-xx-a-bungarotoxin
00017	Biotium	500uG	EUR 519.6
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate
9-00018	Biotium	EUR 592.80 EUR 193.20	500uG 100ug
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate
9-00018	Biotium	EUR 592.80 EUR 193.20	500uG 100ug
Description: Minimum order quantity: 1 unit of 100ug

Biotin-cAMP, diisopropylethylammonium salt:
00020	Biotium	1MG	EUR 376.8
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cAMP, diisopropylethylammonium salt: (20x50ug)
00020-1	Biotium	20ST	EUR 501.6
Description: Minimum order quantity: 1 unit of 20ST

Biotin-cGMP, diisopropylethylammonium salt:
00021	Biotium	1MG	EUR 412.8
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cGMP, diisopropylethylammonium salt: (20x50ug)
00021-1	Biotium	20ST	EUR 537.6
Description: Minimum order quantity: 1 unit of 20ST

Cyanine 644-cAMP:
00022	Biotium	1MG	EUR 589.2
Description: Minimum order quantity: 1 unit of 1MG

Cyanine 644-cAMP: (20x50ug)
00022-1	Biotium	20ST	EUR 750
Description: Minimum order quantity: 1 unit of 20ST

Fluorescein Methotrexate, triammonium salt:
00023	Biotium	1MG	EUR 337.2
Description: Minimum order quantity: 1 unit of 1MG

Staurosporine
00025	Biotium	100uG	EUR 166.8
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF543
00026	Biotium	500uG	EUR 592.8
Description: Minimum order quantity: 1 unit of 500uG

Rhodamine phalloidin 300u
00027	Biotium	300	EUR 414
Description: Minimum order quantity: 1 unit of 300

Biotin-xx-phalloidin
00028	Biotium	100U	EUR 513.6
Description: Minimum order quantity: 1 unit of 100U

Fluorescein-phalloidin
00030	Biotium	300U	EUR 414
Description: Minimum order quantity: 1 unit of 300U

Rhodamine 110 phalloidin
00032	Biotium	300ST	EUR 414
Description: Minimum order quantity: 1 unit of 300ST

Sulforhodamine 101 (Texas-Red) Phalloidin
00033	Biotium	300EU	EUR 414
Description: Minimum order quantity: 1 unit of 300EU

Phalloidin, CF405M
00034	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF405M
00034-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

CF488A-cAMP
00036	Biotium	100ug	EUR 206.4
Description: Minimum order quantity: 1 unit of 100ug

CF640R-cAMP
00037	Biotium	100ug	EUR 206.4
Description: Minimum order quantity: 1 unit of 100ug

Phalloidin, CF555
00040	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555
00040-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF647
00041	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF647
00041-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF488A
00042	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF488A
00042-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF543
00043	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF543
00043-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF568
00044	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF568
00044-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF594
00045	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF594
00045-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF633
00046	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF633
00046-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660R
00047	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660R
00047-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680R
00048	Biotium	300U	EUR 559.2
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680R
00048-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF350
00049	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF350
00049-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF640R
00050	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF640R
00050-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF532
00051	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF532
00051-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660C
00052	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660C
00052-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680
00053	Biotium	300U	EUR 559.2
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680
00053-T	Biotium	50U	EUR 176.4
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF430
00054	Biotium	300U	EUR 538.8
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF430
00054-T	Biotium	50U	EUR 166.8
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF440
00055	Biotium	300U	EUR 538.8
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF440
00055-T	Biotium	50U	EUR 166.8
Description: Minimum order quantity: 1 unit of 50U

Cholera Toxin Subunit B, CF488A conjugate
00070	Biotium	100ug	EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF568 conjugate
00071	Biotium	100ug	EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF594 conjugate
00072	Biotium	100ug	EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF640R conjugate
00073	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF532 conjugate
00074	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF543 conjugate
00075	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF620R conjugate
00076	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF633 conjugate
00077	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF660R conjugate
00078	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF680R conjugate
00079	Biotium	100ug	EUR 338.4
Description: Minimum order quantity: 1 unit of 100ug

Human Transferrin, CF488A conjugate
00081	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF543 conjugate
00082	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF568 conjugate
00083	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF594 conjugate
00084	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF640R conjugate
00085	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF680R conjugate
00086	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg