Eltrombopag is an orally administered, small molecule thrombopoietin receptor (TPO-R) agonist that stimulates platelet manufacturing by a mechanism related, however not similar to endogenous TPO.

Eltrombopag interacts with the transmembrane area of the TPO-R (also referred to as C-MPL) resulting in elevated platelet manufacturing (Erickson-Miller, 2010; Solar et al, 2012).

Eltrombopag is indicated for the remedy of thrombocytopenia in grownup and pediatric sufferers one yr and older with power immune (idiopathic) thrombocytopenia (ITP) who’ve had an inadequate response to corticosteroids, immunoglobulins, or splenectomy.

Eltrombopag has additionally been authorised for the remedy of thrombocytopenia in grownup sufferers with power hepatitis C to permit for the initiation and upkeep of interferon-based remedy and for the remedy of cytopenias in grownup sufferers with extreme aplastic anemia (SAA) who’ve had inadequate responses to immunosuppressive remedy.

That is an open label, single middle pilot trial of eltrombopag in pediatric sufferers receiving most cancers directed remedy for stable tumors.

The function of this examine is to discover the platelet supportive care results and security of eltrombopag in pediatric sufferers (ages one to 18 years of age) present process intensive chemotherapy for malignant stable tumors.

The major endpoint can be to find out the security of eltrombopag in pediatric sufferers present process intensive chemotherapy for malignant stable tumors utilizing CTCAE v5.zero standards.

The secondary endpoint can be to find out the efficacy of eltrombopag in pediatric sufferers present process intensive chemotherapy for malignant stable tumors.

These targets can be assessed by evaluating drug-related toxicities, the platelet response in sufferers and the proportion of topics receiving eltrombopag who’re platelet transfusion-free throughout the time interval of chemotherapy.

The examine will enroll 10 topics with histologically confirmed stable tumors, together with however not restricted to rhabdomyosarcoma, Ewing sarcoma, osteosarcoma, non-rhabdomyosarcoma smooth tissue sarcoma, peripheral nerve sheath tumor, desmoplastic small spherical cell tumor, hepatoblastoma, hepatocellular carcinoma, renal cell carcinoma, larger grade neuroblastoma, medulloblastoma, or different uncommon malignant solidtumors.

The most cancers directed remedy can be a part of commonplace remedy for every affected person and can consist of two to 4 cycles of chemotherapy (or as many as clinically indicated per doctor discretion) to scale back tumor burden, adopted by surgical procedure within the majority of circumstances, and/or radiation in a minority of circumstances, or each in uncommon circumstances at varied instances in the midst of remedy.

After restoration from the surgical procedure and/or radiation, chemotherapy and eltrombopag can be resumed till completion. Every cycle of chemotherapy can be roughly two to 4 weeks (14 to 28 days) in size with chemotherapy administered for one to 5 days per cycle.

The period of chemotherapy varies by routine and underlying malignancy.

Sufferers will provoke eltrombopag on the primary day following the completion of chemotherapy for every cycle (e.g., chemo is run on Days 1-5, eltrombopag to begin on Day 6).

Eltrombopag can be administered each day and the dose can be age dependent (see Desk 5).

Youngsters lower than 6 years of age will obtain a beginning dose of 25 mg by mouth as soon as each day, taken on empty abdomen one hour earlier than or two hours after a meal.

For youngsters larger than or equal to six years of age, the beginning dose can be 75 mg by mouth as soon as each day.

Doses shall be decreased in sufferers of Asian ancestry (e.g., Japanese, Chinese language, Taiwanese, or Korean): for these sufferers larger than or equal to six years of age, the beginning dose can be 50 mg by mouth as soon as each day and for these sufferers lower than 6 years outdated, the beginning dose can be 12.5 mg by mouth as soon as each day.

Eltrombopag can be continued till the platelets are at the least 100,000/µL after the nadir.

Topics can be recruited from the UC Davis ComprehensiveCancerCenter or when they’re admitted to UC Davis Youngsters’s Hospital.

13 mm Diameter Tapped Titanium Tip
0-120-0010	Biologics	13 mm	EUR 595

13 mm Diameter Solid Titanium Tip
0-120-0011	Biologics	13 mm	EUR 533

19 mm Diameter Tapped Titanium Tip
0-120-0012	Biologics	19 mm	EUR 639

19 mm Diameter Solid Titanium Tip
0-120-0013	Biologics	19 mm	EUR 570

25 mm Diameter Tapped Titanium Tip
0-120-0014	Biologics	25 mm	EUR 682

25 mm Diameter Solid Titanium Tip
0-120-0015	Biologics	25 mm	EUR 614

Flat Replaceable Tips 13 mm Diameter Flat Titanium Tip
0-120-0016	Biologics	13 mm	EUR 86
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 19 mm Diameter Flat Titanium Tip
0-120-0017	Biologics	19 mm	EUR 92
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 25 mm Diameter Flat Titanium Tip
0-120-0018	Biologics	25 mm	EUR 100
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Titanium Cup Tip, 250 ml
0-120-0019	Biologics	250 ml	EUR 1377
Description: includes Interface Washers

Microtube Tray, 8 Position (for 250 ml Cup Tip)
0-120-0021	Biologics	each	EUR 113
Description: includes Interface Washers

Continuous Flow Chamber
0-120-0026	Biologics	each	EUR 774
Description: includes Interface Washers

Interface Washers 1.5” Diameter, 5/Pkg
0-120-003	Biologics	1.5'' Diameter	EUR 31

13 mm Diameter Solid Titanium Extender Tip
0-120-0032	Biologics	13 mm	EUR 301

13 mm Diameter Tapped Titanium Extender Tip
0-120-0033	Biologics	13 mm	EUR 362

19 mm Diameter Solid Titanium Extender Tip
0-120-0034	Biologics	19 mm	EUR 315

19 mm Diameter Tapped Titanium Extender Tip
0-120-0035	Biologics	19 mm	EUR 375

25 mm Diameter Solid Titanium Extender Tip
0-120-0036	Biologics	25 mm	EUR 328

25 mm Diameter Tapped Titanium Extender Tip
0-120-0037	Biologics	25 mm	EUR 389

KoldPod, 1.5ml Micro Tube
0-120-0038	Biologics	1.5 ml	EUR 152
Description: Thermo conductive tube pods

KoldPod, 15ml Conical Tube
0-120-0039	Biologics	15 ml	EUR 275
Description: Thermo conductive tube pods

KoldPod, 50ml Conical Tube
0-120-0040	Biologics	50 ml	EUR 290
Description: Thermo conductive tube pods

Model 150 V/T Ultrasonic Homogenizer
0-121-0002	Biologics	210-240V/50-60Hz	EUR 2920
Description: Delivers up to 150 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample processing processing.

Model 300 V/T Ultrasonic Homogenizer
0-122-0002	Biologics	210-240V/50-60Hz	EUR 3520
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample.

SONABOZ Sound Abating Chamber
0-125-0001	Biologics	each	EUR 1020
Description: Reduces cavitational sound emitted during processing.

Model 3000 Ultrasonic Homogenizer
0-127-0002	Biologics	210-240V/50-60Hz	EUR 4120
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip and includes an intergrated Sound Abating Chmaber to reduce cavitational sound emitted during processing. The Timer and Duty Cycle function increase preciosion in sample.

Model 3000MP Ultrasonic Homogenizer
0-128-0002	Biologics	210-240V/50-60Hz	EUR 4720
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip with preciosion control from a microprocessor and a graphical user interface displayed on a large (145 mm) LCD display. The integrated Sound Abating Chamber reduces cavitational sound emitted during processing.

OMNICON® Zone Reader, 210-240V/50-60Hz
0-131-0002	Biologics	210-240V/50-60Hz	EUR 35200
Description: Designed to Perform multi-plate Assays on round 90/100mm Petri Dishes. The integrated LED illumination system provides transmitted light for brightfield and darkfield illumination of transparent media.

OMNI-Noculator Peni Cylinder Filler, 210-240V/50-60Hz
0-134-0002	Biologics	210-240V/50-60Hz	EUR 32200
Description: A robotic liquid handling system designed to dispense Peni Cylinders and fill Peni Cylinders with the corresponding antibiotic liquid sample.

Peni Cylinder Dispenser with Manual Hopper
0-144-0002	Biologics	each	EUR 5406
Description: Dispenser can be configured to dispense 4 or 6 Peni Cylinders onto a petri dish.

Peni Cylinder Dispenser with Motorized Hopper, 100-240V/50-60Hz
0-144-0003	Biologics	100-240V/50-60Hz	EUR 6254
Description: The motorized hopper can be configured to dispense 4 or 6 Peni Cylinders onto a petri Dispenser can be disassembled for disinfection.

Stainless Steel Peni Cylinder with Flat Face
0-144-0005	Biologics	6mm I.D. x 8mm O.D. x 10mm Long	EUR 399
Description: sold in packages of 100 pieces

Stainless Steel Peni Cylinder with Chamfered Face
0-144-0006	Biologics	6mm I.D. x 8mm O.D. x 10mm Long	EUR 412
Description: sold in packages of 100 pieces

Custom development of ELISAs for other species or antibody isotypes not listed in the catalog. Custom testing of samples for IgG/IgM/IgA or total (IgG+IgM+IgA)
000-CUS	Alpha Diagnostics	Custom	EUR 602

Alpha-Bungarotoxin, CF®405S, 500 ug
00002	Biotium	1UG	EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-bungarotoxin, CF405s
00002	Cusabio	500uG	EUR 594
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF®405S, 500 ug
00002-1	Biotium	EA	EUR 527

Alpha-Bungarotoxin, CF®405S 100ug
00002-100ug	Biotium	100uG	EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug
9-00003	Biotium	Ask for price Ask for price	500uG 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug
00003-1	Biotium	EA	EUR 527

Alpha-Bungarotoxin, CF®680R 100ug
9-00003	Biotium	Ask for price Ask for price	500uG 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug
9-00004	Biotium	Ask for price Ask for price	500uG 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug
00004-1	Biotium	EA	EUR 527

Alpha-Bungarotoxin, CF®640R 100ug
9-00004	Biotium	Ask for price Ask for price	500uG 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug
9-00005	Biotium	Ask for price Ask for price	500uG 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug
00005-1	Biotium	EA	EUR 527

Alpha-Bungarotoxin CF®488A 100ug
9-00005	Biotium	Ask for price Ask for price	500uG 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug
9-00006	Biotium	Ask for price Ask for price	500uG 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug
00006-1	Biotium	EA	EUR 527

Alpha-Bungarotoxin, CF®568 100ug
9-00006	Biotium	Ask for price Ask for price	500uG 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug
9-00007	Biotium	Ask for price Ask for price	500uG 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug
00007-1	Biotium	EA	EUR 527

Alpha-Bungarotoxin CF®594 100ug
9-00007	Biotium	Ask for price Ask for price	500uG 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug
9-00009	Biotium	Ask for price Ask for price	500uG 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug
00009-1	Biotium	EA	EUR 527

Alpha-Bungarotoxin, CF®633 100ug
9-00009	Biotium	Ask for price Ask for price	500uG 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

SARS-CoV-2 Indicator Cell Line for RNA Replication - GFP Reporter only
0001-PP-001	IBT Bioservices	1 cell line (can order x amount)	EUR 12000
Description: SARS-CoV-2 GFP reporter cell line using HEK293T (ACE2/TMPRSS2) cells

Alpha-Bungarotoxin, 1 mg
00010-1	Biotium	1MG	EUR 193
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, 1 mg
00010-1-1	Biotium	EA	EUR 193

Fluorescein-Alpha-Bungarotoxin, 500 ug
00011	Biotium	500uG	EUR 376
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-Alpha-Bungarotoxin, 500 ug
00011-1	Biotium	EA	EUR 376

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug
00012	Biotium	500uG	EUR 394
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug
00012-1	Biotium	EA	EUR 394

Fluorescein-alpha-bungarotoxin, 10x50ug
00013	Biotium	10ST	EUR 436
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-alpha-bungarotoxin, 10x50ug
00013-1	Biotium	EA	EUR 436

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug
00014	Biotium	10ST	EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug
00014-1	Biotium	EA	EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug
00015	Biotium	500uG	EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug
00015-1	Biotium	EA	EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug
00016	Biotium	10ST	EUR 560
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug
00016-1	Biotium	EA	EUR 560

Biotin-XX-A-Bungarotoxin, 500 ug
00017	Biotium	500uG	EUR 455
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Biotin-XX-A-Bungarotoxin, 500 ug
00017-1	Biotium	EA	EUR 455

Alpha-Bungarotoxin, CF®555, 500 ug
9-00018	Biotium	Ask for price Ask for price	500uG 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®555, 500 ug
00018-1	Biotium	EA	EUR 527

Alpha-Bungarotoxin, CF®555 100ug
9-00018	Biotium	Ask for price Ask for price	500uG 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Acrylamide, Chemzymes Ultra Pure®
00019-100	Polysciences Europe GmbH	100g	EUR 101.52
Description: 79-06-1

Acrylamide, Chemzymes Ultra Pure®
00019-500	Polysciences Europe GmbH	500g	EUR 270
Description: 79-06-1

Biotin-cAMP, 1 mg
00020	Biotium	1MG	EUR 298
Description: N/A

Biotin-cAMP, 1 mg
00020-1	Biotium	20ST	EUR 298
Description: N/A

Biotin-cAMP, 50 ug
00020-1-1	Biotium	EA	EUR 414

Biotin-cGMP, 1 mg
00021	Biotium	1MG	EUR 331
Description: N/A

Biotin-cGMP, 1 mg
00021-1	Biotium	20ST	EUR 331
Description: N/A

Biotin-cGMP, 20x50 ug
00021-1-1	Biotium	EA	EUR 447

Cyanine 644-cAMP, 1 mg
00022	Biotium	1MG	EUR 496
Description: N/A

Cyanine 644-cAMP, 1 mg
00022-1	Biotium	20ST	EUR 496
Description: N/A

Cyanine 644-cAMP, 20x50 ug
00022-1-1	Biotium	EA	EUR 647

Fluorescein Methotrexate, Triammonium Salt, 1 mg
00023	Biotium	1MG	EUR 285
Description: N/A

Fluorescein Methotrexate, Triammonium Salt, 1 mg
00023-1	Biotium	EA	EUR 285