Cystic Fibrosis Transmembrane Regulator
Nasal Potential Research Using Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators
Flavonoids are a big group of naturally occurring polyphenolic compounds that are ubiquitous all through the plant kingdom and are bio-available in fruits, greens, nuts, seeds, flowers, and bark.
Quercetin has raised specific curiosity as it isn’t solely a main element of the naturally occurring dietary flavonols, nevertheless it additionally appears to have anti-oxidant, anti-carcinogenic, anti-inflammatory, in addition to cardioprotective capabilities.
Lately, our laboratory and others have reported that quercetin, along with its different capabilities, performs a task in enhancing the operate of chloride (Cl-) transport within the (CFTR).
It’s properly established that genistein, a flavone associated to quercetin, will increase mutant and wild-type CFTR channel exercise.
Genistein is now extensively utilized in numerous cell techniques, tissues, and species as a sturdy CFTR activator.
Though it has been extraordinarily useful in laboratory experiments, Genistein interprets poorly into human experiments because it has poor dissolution in solvent.
As nearly all flavonoids activate CFTR, deeper examination of different members of this household is necessary for each medical use in addition to a software for future medical research.
Quercetin is now accessible in well being meals shops as a dietary complement in each capsule in addition to beverage type.
It might even be useful for the therapy of CF and to be used as a direct activator of CFTR to be used in medical trials the place measurements of CFTR exercise are necessary.

Alpha-Bungarotoxin, CF®405S 100ug |
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00002-100ug | Biotium | 100uG | EUR 132 |
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®680R, 500 ug |
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9-00003 | Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®680R, 500 ug |
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00003-1 | Biotium | EA | EUR 527 |
Alpha-Bungarotoxin, CF®680R 100ug |
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9-00003 | Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®640R, 500 ug |
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9-00004 | Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®640R, 500 ug |
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00004-1 | Biotium | EA | EUR 527 |
Alpha-Bungarotoxin, CF®640R 100ug |
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9-00004 | Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®488A, 500 ug |
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9-00005 | Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®488A, 500 ug |
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00005-1 | Biotium | EA | EUR 527 |
Alpha-Bungarotoxin CF®488A 100ug |
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9-00005 | Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®568, 500 ug |
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9-00006 | Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®568, 500 ug |
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00006-1 | Biotium | EA | EUR 527 |
Alpha-Bungarotoxin, CF®568 100ug |
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9-00006 | Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®594, 500 ug |
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9-00007 | Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®594, 500 ug |
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00007-1 | Biotium | EA | EUR 527 |
Alpha-Bungarotoxin CF®594 100ug |
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9-00007 | Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®633, 500 ug |
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9-00009 | Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®633, 500 ug |
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00009-1 | Biotium | EA | EUR 527 |
Alpha-Bungarotoxin, CF®633 100ug |
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9-00009 | Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, 1 mg |
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00010-1 | Biotium | 1MG | EUR 193 |
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, 1 mg |
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00010-1-1 | Biotium | EA | EUR 193 |
Fluorescein-Alpha-Bungarotoxin, 500 ug |
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00011 | Biotium | 500uG | EUR 376 |
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Fluorescein-Alpha-Bungarotoxin, 500 ug |
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00011-1 | Biotium | EA | EUR 376 |
Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug |
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00012 | Biotium | 500uG | EUR 394 |
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug |
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00012-1 | Biotium | EA | EUR 394 |
Fluorescein-alpha-bungarotoxin, 10x50ug |
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00013 | Biotium | 10ST | EUR 436 |
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Fluorescein-alpha-bungarotoxin, 10x50ug |
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00013-1 | Biotium | EA | EUR 436 |
Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug |
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00014 | Biotium | 10ST | EUR 494 |
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug |
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00014-1 | Biotium | EA | EUR 494 |
Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug |
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00015 | Biotium | 500uG | EUR 494 |
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug |
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00015-1 | Biotium | EA | EUR 494 |
Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug |
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00016 | Biotium | 10ST | EUR 560 |
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug |
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00016-1 | Biotium | EA | EUR 560 |
Biotin-XX-A-Bungarotoxin, 500 ug |
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00017 | Biotium | 500uG | EUR 455 |
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Biotin-XX-A-Bungarotoxin, 500 ug |
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00017-1 | Biotium | EA | EUR 455 |
Alpha-Bungarotoxin, CF®555, 500 ug |
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9-00018 | Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®555, 500 ug |
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00018-1 | Biotium | EA | EUR 527 |
Alpha-Bungarotoxin, CF®555 100ug |
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9-00018 | Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Acrylamide, Chemzymes Ultra Pure® |
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00019-100 | Polysciences Europe GmbH | 100g | EUR 91 |
Description: 79-06-1 |
Acrylamide, Chemzymes Ultra Pure® |
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00019-500 | Polysciences Europe GmbH | 500g | EUR 241 |
Description: 79-06-1 |
Biotin-cAMP, 1 mg |
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00020 | Biotium | 1MG | EUR 298 |
Description: N/A |
Biotin-cAMP, 1 mg |
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00020-1 | Biotium | 20ST | EUR 298 |
Description: N/A |
Biotin-cAMP, 50 ug |
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00020-1-1 | Biotium | EA | EUR 414 |
Biotin-cGMP, 1 mg |
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00021 | Biotium | 1MG | EUR 331 |
Description: N/A |
Biotin-cGMP, 1 mg |
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00021-1 | Biotium | 20ST | EUR 331 |
Description: N/A |
Biotin-cGMP, 20x50 ug |
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00021-1-1 | Biotium | EA | EUR 447 |
Cyanine 644-cAMP, 1 mg |
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00022 | Biotium | 1MG | EUR 496 |
Description: N/A |
Cyanine 644-cAMP, 1 mg |
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00022-1 | Biotium | 20ST | EUR 496 |
Description: N/A |
Cyanine 644-cAMP, 20x50 ug |
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00022-1-1 | Biotium | EA | EUR 647 |
Fluorescein Methotrexate, Triammonium Salt, 1 mg |
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00023 | Biotium | 1MG | EUR 285 |
Description: N/A |
Fluorescein Methotrexate, Triammonium Salt, 1 mg |
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00023-1 | Biotium | EA | EUR 285 |
Staurosporine |
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00025 | Biotium | 100uG | EUR 100 |
Description: N/A |
Staurosporine |
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00025-1 | Biotium | EA | EUR 100 |
Alpha-Bungarotoxin, CF®543, 500 ug |
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00026 | Biotium | 500uG | EUR 527 |
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®543, 500 ug |
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00026-1 | Biotium | EA | EUR 527 |
Alpha-Bungarotoxin, CF®543, 100 ug |
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00026-100ug | Biotium | 1UG | EUR 132 |
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Rhodamine Phalloidin 300U |
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00027 | Biotium | 300 | EUR 364 |
Description: N/A |
Rhodamine Phalloidin 300U |
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00027-1 | Biotium | EA | EUR 364 |
Biotin-XX-Phalloidin |
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00028 | Biotium | 100U | EUR 466 |
Description: N/A |
Biotin-XX-Phalloidin |
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00028-1 | Biotium | EA | EUR 466 |
Fluorescein-Phalloidin |
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00030 | Biotium | 300U | EUR 364 |
Description: N/A |
Fluorescein-Phalloidin |
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00030-1 | Biotium | EA | EUR 364 |
Rhodamine 110 Phalloidin |
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00032 | Biotium | 300ST | EUR 364 |
Description: N/A |
Rhodamine 110 Phalloidin |
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00032-1 | Biotium | EA | EUR 364 |
Sulforhodamine 101 (Texas Red®) Phalloidin |
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00033 | Biotium | 300EU | EUR 364 |
Description: N/A |
Sulforhodamine 101 (Texas Red®) Phalloidin |
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00033-1 | Biotium | EA | EUR 364 |
Phalloidin, CF®405M |
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00034 | Biotium | 300U | EUR 482 |
Description: N/A |
Phalloidin, CF®405M |
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00034-1 | Biotium | EA | EUR 482 |
Phalloidin, CF®405M |
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00034-T | Biotium | 50U | EUR 101 |
Description: N/A |
Phalloidin, CF®405M |
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00034-T-1 | Biotium | EA | EUR 101 |
CF®488A-cAMP |
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00036 | Biotium | 100ug | EUR 136 |
Description: N/A |
CF®488A-cAMP |
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00036-1 | Biotium | EA | EUR 136 |
CF®640R-cAMP |
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00037 | Biotium | 100ug | EUR 136 |
Description: N/A |
CF®640R-cAMP |
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00037-1 | Biotium | EA | EUR 136 |
Phalloidin, CF555 |
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00040 | Biotium | 300U | EUR 530.4 |
Description: Minimum order quantity: 1 unit of 300U |
Phalloidin, CF555 |
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00040-T | Biotium | 50U | EUR 159.6 |
Description: Minimum order quantity: 1 unit of 50U |
Phalloidin, CF®647, 300 U |
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00041 | Biotium | 300U | EUR 482 |
Description: N/A |
Phalloidin, CF®647, 300 U |
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00041-1 | Biotium | EA | EUR 482 |
Via a higher understanding of CFTR biogenesis and activation, new therapeutic approaches that restore exercise to mutant CFTR molecules in vitro and in vivo are being developed.
Biomarkers that may detect exercise of rescued CFTR are required to measure therapeutic results of recent compounds.
Present strategies have but to indicate constant rescue of CFTR exercise, elevating the significance of optimizing detection methods, together with the simplest NPD endpoint.
This can be significantly necessary for topics harboring the ∆F508 mutation which along with its cell processing abnormality, additionally displays a channel gating defect (it doesn’t activate with the standard NPD agonist isoproterenol) thereby lowering detection of rescued protein.
The investigators have earlier expertise evaluating various CFTR activating brokers, each in CF animal fashions, and in human topics.
By including quercetin to the sequence of perfusion options for NPD, the investigators could also be higher suited to detect CFTR exercise of rescued mutant protein. In vitro experiments present that quercetin induces activation of CFTR additive to that seen with present NPD reagents.
Preliminary in vivo experiments of non-CF people mirrored these outcomes and present that quercetin prompts CFTR in human NPD checks (n=12).
Importantly, quercetin perfusion was well-tolerated by a validated sinus questionnaire and doctor assessed nasal examination score.
As preliminary knowledge counsel perfusion of quercetin could enhance faulty CFTR activation in floor localized ΔF508, use of this agent inside an NPD protocol is prone to enhance detection of ΔF508 CFTR resident on the cell floor, representing a possible means to establish new candidates for systemic CFTR potentiator therapies.
Detection of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Exercise in Rectal Tissues From Human Topics
CF analysis has superior to the purpose the place small molecule brokers have been developed to beat the underlying genetic defects brought on by CFTR mutations.
There’s a crucial have to develop new delicate biomarkers of CFTR operate and biochemistry that can be utilized in early section medical trials to display biologic results of investigative brokers in vivo.
Intestinal Present Measurement (ICM) from rectal biopsy samples is an assay that has been confirmed to be delicate and particular for CFTR operate.
This methodology and web site of investigation is especially engaging, since CFTR is expressed at excessive ranges within the rectum, it isn’t altered by illness manifestations, and the tissue might be studied ex vivo, offering extra flexibility within the nature of the strategies to detect and quantify CFTR exercise.
This research will assist within the improvement of recent biomarkers in human rectal tissue to be used in CF medical trials. Testing compounds which can be designed to restore operate to disease-causing CFTR genes and proteins will present a possibility to enhance and standardize strategies within the acquisition and measurement of CFTR exercise in rectal biopsy specimens.
Test productt 2 |
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aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa | National Diagnostics | 0 | Ask for price |
Diogenes Kit |
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NAT1000 | National Diagnostics | 1KIT | EUR 270 |
Hydrogen Peroxide Assay Kit |
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NAT1002 | National Diagnostics | 1KIT | EUR 308.4 |
ProtoBlock System |
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NAT1004 | National Diagnostics | 1KIT | EUR 122.4 |
450ML PBS 10X |
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NAT1006 | National Diagnostics | 450ML | EUR 96 |
4L PBS 10X |
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NAT1008 | National Diagnostics | 4L | EUR 238.8 |
ProtoGlow ECL 200ml Kit |
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NAT1010 | National Diagnostics | EACH | EUR 354 |
ProtoGlow ECL 500ml Kit |
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NAT1012 | National Diagnostics | EACH | EUR 627.6 |
100G Acrylamide |
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NAT1014 | National Diagnostics | 100G | EUR 120 |
500G Acrylamide |
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NAT1016 | National Diagnostics | 500G | EUR 261.6 |
1KG Acrylamide |
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NAT1018 | National Diagnostics | 1KG | EUR 412.8 |
25G AquaPor LE |
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NAT1020 | National Diagnostics | 25G | EUR 132 |
100G AquaPor LE GTAC |
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NAT1022 | National Diagnostics | 100G | EUR 250.8 |
500G AquaPor LE GTAC |
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NAT1024 | National Diagnostics | 500G | EUR 878.4 |
25G AquaPor ES |
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NAT1026 | National Diagnostics | 25G | EUR 152.4 |
100G AquaPor ES |
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NAT1028 | National Diagnostics | 100G | EUR 350.4 |
25G AquaPor LM |
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NAT1030 | National Diagnostics | 25G | EUR 288 |
100G AquaPor LM |
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NAT1032 | National Diagnostics | 100G | EUR 860.4 |
25G AquaPor HR |
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NAT1034 | National Diagnostics | 25G | EUR 236.4 |
100G AquaPor HR |
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NAT1036 | National Diagnostics | 100G | EUR 592.8 |
25G AquaPor 3:1 |
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NAT1038 | National Diagnostics | 25G | EUR 250.8 |
100G AquaPor 3:1 |
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NAT1040 | National Diagnostics | 100G | EUR 570 |
25G Bis (Methylene Bis-Acrylamide) |
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NAT1042 | National Diagnostics | 25G | EUR 100.8 |
25G DATD Ultrapure |
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NAT1044 | National Diagnostics | 25G | EUR 168 |
250G Glycine |
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NAT1046 | National Diagnostics | 250G | EUR 94.8 |
1KG Glycine Ultrapure |
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NAT1048 | National Diagnostics | 1KG | EUR 128.4 |
250G Tris |
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NAT1050 | National Diagnostics | 250G | EUR 102 |
1KG Tris Ultrapure |
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NAT1052 | National Diagnostics | 1KG | EUR 177.6 |
100G Tricine |
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NAT1054 | National Diagnostics | 100G | EUR 120 |
100G Ion Exchange Resin (mixed bed) |
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NAT1056 | National Diagnostics | 100G | EUR 96 |
25G Riboflavin |
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NAT1058 | National Diagnostics | 25G | EUR 96 |
25ML TEMED |
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NAT1060 | National Diagnostics | 25ML | EUR 99.6 |
25G Ammonium Persulfate |
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NAT1062 | National Diagnostics | 25G | EUR 96 |
100G Ammonium Persulfate |
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NAT1064 | National Diagnostics | 100G | EUR 118.8 |
1G Dithiothreitol (DTT) |
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NAT1066 | National Diagnostics | 1G | EUR 103.2 |
5G Dithiothreitol (DTT) |
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NAT1068 | National Diagnostics | 5G | EUR 183.6 |
50ML 2-Mercaptoethanol |
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NAT1070 | National Diagnostics | 50ML | EUR 112.8 |
100G SDS Ultrapure |
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NAT1072 | National Diagnostics | 100G | EUR 111.6 |
1KG SDS Ultrapure |
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NAT1074 | National Diagnostics | 1KG | EUR 457.2 |
250G Urea |
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NAT1076 | National Diagnostics | 250G | EUR 98.4 |
1KG Urea |
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NAT1078 | National Diagnostics | 1KG | EUR 138 |
450ML Glycerol Ultrapure |
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NAT1080 | National Diagnostics | 450ML | EUR 132 |
200ML Tween 20 Ultrapure |
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NAT1082 | National Diagnostics | 200ML | EUR 132 |
1L Tween 20 |
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NAT1084 | National Diagnostics | 1L | EUR 169.2 |
200ML Formamide |
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NAT1086 | National Diagnostics | 200ML | EUR 111.6 |
500ML Boric Acid |
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NAT1088 | National Diagnostics | 500ML | EUR 103.2 |
100G EDTA |
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NAT1090 | National Diagnostics | 100G | EUR 94.8 |
500G EDTA |
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NAT1092 | National Diagnostics | 500G | EUR 177.6 |
GelDry Film 11 X 12 cm |
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NAT1094 | National Diagnostics | PK50 | EUR 100.8 |
25ML Formamide CE |
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NAT1096 | National Diagnostics | 25ML | Ask for price |
25ML Glass Bond |
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NAT1098 | National Diagnostics | 25ML | EUR 158.4 |
450ML Glass Free |
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NAT1100 | National Diagnostics | 450ML | EUR 196.8 |
GelDry Film 22.5 X 22.5 cm |
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NAT1102 | National Diagnostics | PK50 | EUR 130.8 |
1L DEPC Treated Water |
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NAT1104 | National Diagnostics | 1L | EUR 120 |
Sterling Rapid Silver Stain Kit |
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NAT1106 | National Diagnostics | 1KIT | EUR 265.2 |
1L ProtoBlue Safe |
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NAT1108 | National Diagnostics | 1L | EUR 159.6 |
4L ProtoBlue Safe |
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NAT1110 | National Diagnostics | 4L | EUR 282 |
1L ProtoStain Blue |
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NAT1112 | National Diagnostics | 1L | EUR 164.4 |
25ML Nuclistain |
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NAT1114 | National Diagnostics | 25ML | EUR 128.4 |
450ML AcrylaGel 30% |
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NAT1116 | National Diagnostics | 450ML | EUR 128.4 |
1L AcrylaGel 30% |
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NAT1118 | National Diagnostics | 1L | EUR 177.6 |
450ML Bis-AcrylaGel 2% |
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NAT1120 | National Diagnostics | 450ML | EUR 98.4 |
1L Bis-AcrylaGel 2% |
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NAT1122 | National Diagnostics | 1L | EUR 111.6 |
450ML UreaGel 29:1 Concentrate |
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NAT1124 | National Diagnostics | 450ML | EUR 133.2 |
1L UreaGel 29:1 Concentrate |
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NAT1126 | National Diagnostics | 1L | EUR 183.6 |
UreaGel 29:1 System 1L Kit |
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NAT1128 | National Diagnostics | EACH | EUR 171.6 |
UreaGel 29:1 System 2.2L Kit |
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NAT1130 | National Diagnostics | EACH | EUR 253.2 |
450ML SequaGel UreaGel Concentrate |
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NAT1132 | National Diagnostics | 450ML | EUR 126 |
1L SequaGel UreaGel Concentrate |
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NAT1134 | National Diagnostics | 1L | EUR 160.8 |
SequaGel Sequencing System 1L Kit |
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NAT1136 | National Diagnostics | 1KIT | EUR 171.6 |
SequaGel Sequencing System 2.2L Kit |
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NAT1138 | National Diagnostics | EACH | EUR 253.2 |
100ML SequaGel Buffer |
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NAT1140 | National Diagnostics | 100ML | EUR 80.4 |
200ML SequaGel UreaGel Buffer |
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NAT1142 | National Diagnostics | 200ML | EUR 84 |
450ML SequaGel UreaGel-6 |
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NAT1144 | National Diagnostics | 450ML | EUR 115.2 |
1L SequaGel UreaGel-6 |
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NAT1146 | National Diagnostics | 1L | EUR 151.2 |
450ML SequaGel UreaGel-8 |
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NAT1148 | National Diagnostics | 450ML | EUR 115.2 |
1L SequaGel UreaGel-8 |
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NAT1150 | National Diagnostics | 1L | EUR 151.2 |
450ML SequaGel UreaGel Diluent |
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NAT1152 | National Diagnostics | 450ML | EUR 90 |
1L SequaGel UreaGel Diluent |
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NAT1154 | National Diagnostics | 1L | EUR 103.2 |
90ML SequaGel Complete Buffer |
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NAT1156 | National Diagnostics | 90ML | EUR 79.2 |
200ML SequaGel UreaGel Complete Buffer |
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NAT1158 | National Diagnostics | 200ML | EUR 85.2 |